Metals and oxidative stress in aquatic decapod crustaceans: A review with special reference to shrimp and crabs

Frías-Espericueta, Martín G.; Bautista-Covarrubias, Juan Carlos; Osuna-Martínez, Carmen Cristina; Delgado-Alvarez, Carolina; Bojórquez, Carolina; Aguilar-Juárez, Marisela; Roos-Muñoz, Sarahí; Osuna-López, Isidro; Páez‐Osuna, Federico

doi:10.1016/j.aquatox.2021.106024

Cited by 59 publications

(21 citation statements)

References 100 publications

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“…Consequently, ROS and MDA levels reflect the degree of oxidative damage. In order to protect themselves from ROS, organisms (such as crustaceans) have mechanisms of non-enzymatic and enzymatic antioxidants [ 28 ]. Non-enzymatic antioxidants contain tocopherols, ascorbic acid, and glutathione (GSH).…”

Section: Introductionmentioning

confidence: 99%

Mercury Induced Tissue Damage, Redox Metabolism, Ion Transport, Apoptosis, and Intestinal Microbiota Change in Red Swamp Crayfish (Procambarus clarkii): Application of Multi-Omics Analysis in Risk Assessment of Hg

et al. 2022

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As one of the most toxic elements, mercury (Hg) is a widespread toxicant in aquatic environments. Crayfish are considered suitable for indicating the impact of heavy metals on aquatic crustaceans. Nevertheless, Hg toxicity on Procambarus clarkii is largely unknown. In this research, the acute Hg-induced alterations of biochemical responses, histopathology, hepatopancreatic transcriptome, and intestinal microbiome of Procambarus clarkii were studied. Firstly, Hg induced significant changes in reactive oxygen species (ROS) and malonaldehyde (MDA) content as well as antioxidant enzyme activity. Secondly, Hg exposure caused structural damage to the hepatopancreas (e.g., vacuolization of the epithelium and dilatation of the lumen) as well as to the intestines (e.g., dysregulation of lamina epithelialises and extension of lamina proprias). Thirdly, after treatment with three different concentrations of Hg, RNA-seq assays of the hepatopancreas revealed a large number of differentially expressed genes (DEGs) linked to a specific function. Among the DEGs, a lot of redox metabolism- (e.g., ACOX3, SMOX, GPX3, GLO1, and P4HA1), ion transport- (e.g., MICU3, MCTP, PYX, STEAP3, and SLC30A2), drug metabolism- (e.g., HSP70, HSP90A, CYP2L1, and CYP9E2), immune response- (e.g., SMAD4, HDAC1, and DUOX), and apoptosis-related genes (e.g., CTSL, CASP7, and BIRC2) were identified, which suggests that Hg exposure may perturb the redox equilibrium, disrupt the ion homeostasis, weaken immune response and ability, and cause apoptosis. Fourthly, bacterial 16S rRNA gene sequencing showed that Hg exposure decreased bacterial diversity and dysregulated intestinal microbiome composition. At the phylum level, there was a marked decrease in Proteobacteria and an increase in Firmicutes after exposure to high levels of Hg. With regards to genus, abundances of Bacteroides, Dysgonomonas, and Arcobacter were markedly dysregulated after Hg exposures. Our findings elucidate the mechanisms involved in Hg-mediated toxicity in aquatic crustaceans at the tissue, cellular, molecular as well as microbial levels.

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Section: Introductionmentioning

confidence: 99%

Mercury Induced Tissue Damage, Redox Metabolism, Ion Transport, Apoptosis, and Intestinal Microbiota Change in Red Swamp Crayfish (Procambarus clarkii): Application of Multi-Omics Analysis in Risk Assessment of Hg

et al. 2022

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“…Significant pressure decreases as well as increases may cause malfunctioning of the electron transport chain in mitochondria, which in turn can lead to electron leakage and increases in ROS production with subsequent damage to the cell. Most ROS have a very short half-life, and hence their elevated production is usually determined by successive products of the peroxidation of cellular components such as lipids or by indirect proxy markers such as the activities of various antioxidant enzymes, which usually should balance ROS [ 25 , 26 ]. Another basic requirement to survive under stressful conditions other than preventing oxidative stress is maintaining a sufficient energy supply.…”

Section: Introductionmentioning

confidence: 99%

Metabolic Tolerance to Atmospheric Pressure of Two Freshwater Endemic Amphipods Mostly Inhabiting the Deep-Water Zone of the Ancient Lake Baikal

Shirokova

Gurkov

Drozdova

et al. 2022

Insects

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Lake Baikal is the only freshwater reservoir inhabited by deep-water fauna, which originated mostly from shallow-water ancestors. Ommatogammarus flavus and O. albinus are endemic scavenger amphipods (Amphipoda, Crustacea) dwelling in wide depth ranges of the lake covering over 1300 m. O. flavus had been previously collected close to the surface, while O. albinus has never been found above the depth of 47 m. Since O. albinus is a promising model species for various research, here we tested whether O. albinus is less metabolically adapted to atmospheric pressure than O. flavus. We analyzed a number of energy-related traits (contents of glucose, glycogen and adenylates, as well as lactate dehydrogenase activity) and oxidative stress markers (activities of antioxidant enzymes and levels of lipid peroxidation products) after sampling from different depths and after both species’ acclimation to atmospheric pressure. The analyses were repeated in two independent sampling campaigns. We found no consistent signs of metabolic disturbances or oxidative stress in both species right after lifting. Despite O. flavus surviving slightly better in laboratory conditions, during long-term acclimation, both species showed comparable reactions without critical changes. Thus, the obtained data favor using O. albinus along with O. flavus for physiological research under laboratory conditions.

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“…A profusion of ecotoxicological studies has highlighted the importance of heavy metal toxicity in aquatic environments [e.g., 10,11,12,13]. Most studies of heavy metal toxicity in aquatic organisms concern their bioaccumulation in different tissues [1,14,15] and effects on physiological and biochemical processes like osmoregulatory capability and aerobic and oxidative stress metabolism [1,11,16]. The toxic effects of heavy metals at the molecular level are poorly known since the interactions between such metal ions and enzymes are complex [17,18].…”

Section: Introductionmentioning

confidence: 99%

“…Cobalt titers in brachyuran crabs from marine/estuarine ecosystems range from 0.26 to 0.43 µg Co 2+ g −1 soft tissue dry mass in Callinectes sapidus [32]; 0.91 to 1.2 µg Co 2+ g −1 hepatopancreas dry mass in male and female Portunus segnis [33]; and 0.72 to 0.86 µg Co 2+ g −1 dry mass in whole Carcinus maenas [34]. The lack of molecular information regarding harm to aquatic organisms, including the effects of Co 2+ , has impaired our overall comprehension of environmental damage and particularly of toxicity owing to bioaccumulation in marine organisms [16,23,25,35].…”

Section: Introductionmentioning

confidence: 99%

Differential effects of cobalt ionsin vitroon gill (Na⁺, K⁺)-ATPase kinetics in the blue crabCallinectes danae(Decapoda, Brachyura)

Leone¹,

Fabri

Costa³

et al. 2022

Preprint

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To evaluate the crustacean gill (Na+, K+)-ATPase as a molecular marker for toxic contamination by heavy metals of estuarine and coastal environments, we provide a comprehensive analysis of the effects of Co2+ in vitro on modulation of the K+-phosphatase activity of a gill (Na+, K+)-ATPase from the blue crab Callinectes danae. Using p-nitrophenyl phosphate as a substrate, Co2+ can act as both stimulator and inhibitor of K+-phosphatase activity. Without Mg2+, Co2+ stimulates K+-phosphatase activity similarly but with a 4.5-fold greater affinity than with Mg2+. With Mg2+, K+-phosphatase activity is almost completely inhibited by Co2+. Substitution of Mg2+ by Co2+ slightly increases enzyme affinity for K+ and NH4+. Independently of Mg2+, ouabain inhibition is unaffected by Co2+. Mg2+ displaces bound Co2+ from the Mg2+-binding site in a concentration dependent mechanism. However, at saturating Mg2+ concentrations, Co2+ does not displace Mg2+ from its binding site even at elevated concentrations. Saturation by Co2+ of the Mg2+ binding site does not affect pNPP recognition by the enzyme. Given that the interactions between heavy metal ions and enzymes are particularly complex, their toxic effects at the molecular level are poorly understood. Our findings elucidate partly the mechanism of action of Co2+ on a crustacean gill (Na+, K+)-ATPase.

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Metals and oxidative stress in aquatic decapod crustaceans: A review with special reference to shrimp and crabs

Cited by 59 publications

References 100 publications

Mercury Induced Tissue Damage, Redox Metabolism, Ion Transport, Apoptosis, and Intestinal Microbiota Change in Red Swamp Crayfish (Procambarus clarkii): Application of Multi-Omics Analysis in Risk Assessment of Hg

Mercury Induced Tissue Damage, Redox Metabolism, Ion Transport, Apoptosis, and Intestinal Microbiota Change in Red Swamp Crayfish (Procambarus clarkii): Application of Multi-Omics Analysis in Risk Assessment of Hg

Metabolic Tolerance to Atmospheric Pressure of Two Freshwater Endemic Amphipods Mostly Inhabiting the Deep-Water Zone of the Ancient Lake Baikal

Differential effects of cobalt ionsin vitroon gill (Na⁺, K⁺)-ATPase kinetics in the blue crabCallinectes danae(Decapoda, Brachyura)

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Metals and oxidative stress in aquatic decapod crustaceans: A review with special reference to shrimp and crabs

Cited by 59 publications

References 100 publications

Mercury Induced Tissue Damage, Redox Metabolism, Ion Transport, Apoptosis, and Intestinal Microbiota Change in Red Swamp Crayfish (Procambarus clarkii): Application of Multi-Omics Analysis in Risk Assessment of Hg

Mercury Induced Tissue Damage, Redox Metabolism, Ion Transport, Apoptosis, and Intestinal Microbiota Change in Red Swamp Crayfish (Procambarus clarkii): Application of Multi-Omics Analysis in Risk Assessment of Hg

Metabolic Tolerance to Atmospheric Pressure of Two Freshwater Endemic Amphipods Mostly Inhabiting the Deep-Water Zone of the Ancient Lake Baikal

Differential effects of cobalt ionsin vitroon gill (Na+, K+)-ATPase kinetics in the blue crabCallinectes danae(Decapoda, Brachyura)

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Differential effects of cobalt ionsin vitroon gill (Na⁺, K⁺)-ATPase kinetics in the blue crabCallinectes danae(Decapoda, Brachyura)