Metaloproteinasas de la matriz extracelular y su participación en el proceso de cicatrización

Ferranti-Ramos, Andrea; Garza-Garza, Gregorio; Bátiz-Armenta, Jorge; Martínez-Delgado, Guillermo Hernán; Garza-Álvarez, Francisco De la; Martínez-Menchaca, Héctor; Silva, Gerardo Rivera

doi:10.18273/revmed.v30n2-2017006

Cited by 6 publications

(5 citation statements)

References 41 publications

(49 reference statements)

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“…These bacterial strains can produce endotoxins that, in turn, raise the levels of pro-inflammatory cytokines, such as IL-1 and TNF-α. If this continues, the wound can enter a chronic state and fail to heal [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

The Wound-Healing Effect of Mango Peel Extract on Incision Wounds in a Murine Model

et al. 2022

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Mangifera indica can generate up to 60% of polluting by-products, including peels. However, it has been shown that flavonoids and mangiferin are mainly responsible for the antioxidant, anti-inflammatory, and antibacterial activities closely related to the wound-healing process. The chemical composition of MEMI (methanolic extract of M. indica) was analyzed by HPLC-DAD, as well as concentrations of total phenol (TPC) and flavonoids (TFC) and antioxidant activity (SA50). Wound-healing efficacy was determined by measurements of wound contraction, histological analysis, and tensiometric method; moreover, anti-inflammatory, antibacterial, and acute dermal toxicity (OECD 402) were also evaluated. Phenol, resorcinol, conjugated resorcinol, and mangiferin were detected. TPC, TFC, and SA50 were 136 mg GAE/g, 101.66 mg QE/g, and 36.33 µg/mL, respectively. Tensile strength and wound contraction closure did not show significant differences between MEMI and dexpanthenol groups. Histological analysis (after 14 days) shows a similar architecture between MEMI treatment and normal skin. MEMI exhibits a reduction in edema. Staphylococcus epidermidis had an MIC of 2 mg/mL, while Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli reached 4 mg/mL. The MEMI showed no signs of toxicity. Therefore, this study demonstrates multiple targets that flavonoids and mangiferin of MEMI may present during the healing process.

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Section: Discussionmentioning

confidence: 99%

The Wound-Healing Effect of Mango Peel Extract on Incision Wounds in a Murine Model

et al. 2022

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“…The evidence raised in this work allowed us to notice the presence of genes associated with muscle injuries, which is related to their participation in the processes that involve the structural integrity of a complex or its assembly inside or outside a cell as the processes that develop with the extracellular matrix. 13 The analysis of the expression network allowed to identify 3 nodes, where their expression stands out, finding that ITGB6 acts as an adhesion factor from the signaling of the extracellular matrix, wound healing and fibrosis, 14 since its expression in the keratinocytes at the edge of the wound allows re-epithelialization 15 estudios 16 state that this gene is not detected until after mucular injury, an aspect that requires further review.…”

Section: Discussionmentioning

confidence: 99%

Differential expression of genes associated with sports injuries

Molano Tobar,

Rodriguez Ortiz,

Vallejo

2020

IJMBOA

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Candidate gene studies in sports injuries pose a valid new approach to investigate the genetic basis of these. In this context, our objective was to analyze the differential expression and interaction of genes associated with sports injuries using a bio informatic approach. For this study, we analyzed 31 genes associated with sports injuries previously reported in the literature. Expression analysis was performed using the Z-ratio and a protein-protein interaction network was constructed in STRING 10.0. The GO categories associated with outstanding biological processes in the network were also taken from STRING 10.0. The expression network obtained allowed establishing three clusters with a significant number of interactions, the highest interactions were found in the genes COL1A1, COL1A2, COL3A1, COL4A1, COL6A1 and COL5A1. According to the Z-ratio, the most over expressed genes were ITGB6 (z-ratio 4.32), COL1A2 (z-ratio 4.07), COL6A2 (z-ratio 3.99) and TIMM17A. In conclusion, the over-expression of genes is presented, which according to the current literature has been analyzed very little, from the sports field associated with sports injuries, a fact that merits further research. Also, we highlight the importance of bioinformatics as a complementary tool to the analysis of sports genomic data.

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“…En esta fase el proceso de angiogénesis y la proliferación celular se detienen y el exceso de células abandona la herida y/o sufren apoptosis (Serra et al, 2017). Los nuevos vasos sufrirán regresión, dejando en su sitio colágeno y proteínas de matriz extracelular, que serán posteriormente degradados por la acción de las metaloproteinasas de matriz extracelular (MPM) y las metaloproteinasas inhibidoras del tejido (MPIT) que son secretadas por los fibroblastos, macrófagos y neutrófilos (desJardins- Park, Foster & Longaker, 2018;Ferranti-Ramos et al, 2017). La degradación de la matriz extracelular formada inicialmente por colágeno I, será reemplazada por la deposición del colágeno tipo III, que es más fuerte, grueso y permanente.…”

Section: Fisiopatología De La Herida De La Pielunclassified

Recubrimientos para heridas con Aloe-gel combinado con alginato, pectina y quitosano: aplicaciones in vivo

et al. 2020

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La recuperación de las heridas en la piel es un proceso complejo e interrelacionado que se desarrolla a través de varias fases (hemostasia, inflamatoria, proliferativa y remodelación). El Aloe-gel (AG) ha sido considerado un biomaterial que puede coadyuvar en la modulación, regeneración y aceleración de la recuperación del tejido celular dañado e incluso se ha recomendado para su aplicación en heridas o quemaduras superficiales de tipo cutáneas.Debido a lo anterior, se ha promovido el uso del AG como un importante biomaterial que puede ser utilizado en la fabricación de recubrimientos para heridas (RH). Sin embargo, su aplicación directa sobre las heridas presenta desventajas, ya que puede inducir a deshidratación en la zona, rápida oxidación de sus fitoconstituyentes y baja proporción de solutos. Una estrategia que puede ayudar a conservar su actividad biológica y a sus componentes inalterados y funcionales, es su incorporación hacia matrices de polisacáridos como el alginato, pectina y quitosano. Aunque existen ya algunos biomateriales de esta mezcla que se han propuestos como RH, su aplicación en modelos in vivo es aún limitado. Por lo anterior, la presente revisión pretende documentar el desarrollo de RH con AG incorporado en polisacáridos y sus efectos en la recuperación de heridas in vivo.

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Metaloproteinasas de la matriz extracelular y su participación en el proceso de cicatrización

Cited by 6 publications

References 41 publications

The Wound-Healing Effect of Mango Peel Extract on Incision Wounds in a Murine Model

The Wound-Healing Effect of Mango Peel Extract on Incision Wounds in a Murine Model

Differential expression of genes associated with sports injuries

Recubrimientos para heridas con Aloe-gel combinado con alginato, pectina y quitosano: aplicaciones in vivo

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