Metallothionein, oxidative stress and trace metals in gills and liver of demersal and pelagic fish species from Kuwaits’ marine area

Beg, M. U.; Al-Jandal, Noura; Al-Subiai, Sherain N.; Karam, Qusaie; Husain, Sanaa N.; Butt, S. A.; Ali, Ameena; Al-Hasan, E.; Al-Dufaileej, S.; Al-Husaini, M.

doi:10.1016/j.marpolbul.2015.07.058

Cited by 24 publications

(26 citation statements)

References 46 publications

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“…In contrast, bioaccumulation of Al and Se was examined much less frequently, or in the case of Ga not at all. Metal bioaccumulation, however, does not always reflect environmental metal concentrations [66, 67, 83, 84], and can vary with fish species [67, 74, 82, 85–87], tissue [66, 67, 73, 86], and life history stage [70, 82], with exposure pathways [82, 88, 89], with season [90, 91], and can be influenced by metal speciation and bioavailability [73, 85, 92]. Hence, when using biomarkers to assess fish health, metal bioaccumulation should be used in conjunction with other biomarkers to indicate whether biological responses are related to bioaccumulation.…”

Section: Resultsmentioning

confidence: 99%

“…Additionally, in one study different responses were reported when the same fish population were exposed to the same sediment but under either laboratory or field conditions [112]. This variability is likely due to species-specific responses [83, 101], tissue-specific responses [113], seasonal and annual variations [114] and responses to contaminants other than metals (e.g. organics [97, 98]).…”

Section: Resultsmentioning

confidence: 99%

“…organics [97, 98]). For example, GST activity was generally higher in liver tissue in Cynoglossus arel from polluted locations, but not so in Acanthopagrus latus even though hepatic metal bioaccumulation was confirmed [83]. The confirmed metal contamination of marine sediment suggest that these differences are due to different feeding habits, with C .…”

Section: Resultsmentioning

confidence: 99%

“…arel a bottom dwelling fish and A . latus a more pelagic species [83]. In addition, tissue-specific responses are potentially related to differential metal accumulation with the liver accumulating 30 times more Cu than the kidney, and twice the concentration of Zn [113].…”

Section: Resultsmentioning

confidence: 99%

“…Even within the same tissue (e.g. gills), however, GST levels have shown an increase [115], a decrease [84], and no significant response [83] to environmental metal concentrations.…”

Section: Resultsmentioning

confidence: 99%

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A protocol for identifying suitable biomarkers to assess fish health: A systematic review

2017

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BackgroundBiomarkers have been used extensively to provide the connection between external levels of contaminant exposure, internal levels of tissue contamination, and early adverse effects in organisms.ObjectivesTo present a three-step protocol for identifying suitable biomarkers to assess fish health in coastal and marine ecosystems, using Gladstone Harbour (Australia) as a case study.MethodsPrior to applying our protocol, clear working definitions for biomarkers were developed to ensure consistency with the global literature on fish health assessment. First, contaminants of concern were identified based on the presence of point and diffuse sources of pollution and available monitoring data for the ecosystem of interest. Second, suitable fish species were identified using fisheries dependent and independent data, and prioritised based on potential pathways of exposure to the contaminants of concern. Finally, a systematic and critical literature review was conducted on the use of biomarkers to assess the health of fish exposed to the contaminants of concern.Results/DiscussionWe present clear working definitions for bioaccumulation markers, biomarkers of exposure, biomarkers of effect and biomarkers of susceptibility. Based on emission and concentration information, seven metals were identified as contaminants of concern for Gladstone Harbour. Twenty out of 232 fish species were abundant enough to be potentially suitable for biomarker studies; five of these were prioritised based on potential pathways of exposure and susceptibility to metals. The literature search on biomarkers yielded 5,035 articles, of which 151met the inclusion criteria. Based on our review, the most suitable biomarkers include bioaccumulation markers, biomarkers of exposure (CYP1A, EROD, SOD, LPOX, HSP, MT, DNA strand breaks, micronuclei, apoptosis), and biomarkers of effect (histopathology, TAG:ST).ConclusionOur protocol outlines a clear pathway to identify suitable biomarkers to assess fish health in coastal and marine ecosystems, which can be applied to biomarker studies in aquatic ecosystems around the world.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…Even within the same tissue (e.g. gills), however, GST levels have shown an increase [115], a decrease [84], and no significant response [83] to environmental metal concentrations.…”

Section: Resultsmentioning

confidence: 99%

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