Metallothionein 2A gene polymorphism and trace elements in mother-newborn pairs in the Croatian population

Sekovanić, Ankica; Jurasović, Jasna; Piasek, Martina; Pašalić, Daria; Orct, Tatjana; Grgec, Antonija Sulimanec; Stasenko, Sandra; Čakanić, Karmen Branović; Jazbec, Anamarija

doi:10.1016/j.jtemb.2017.10.011

Cited by 22 publications

(30 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…59,72 Despite the low levels of Cd detected in the fetus, MT concentrations in the fetal liver are important. 104 Likewise, it has also been established that there is a comparable expression of fetal MTs in the liver relative to those in the kidneys, because of the similarity in the Cd concentrations found in both organs. 107 Moreover, the analogy of the pattern of MT synthesis Fig.…”

Section: Fetusmentioning

confidence: 99%

“…Thus, those mothers presenting the MT2-heterozygote genotype have higher Cd concentration in maternal blood, while the levels are lower in those with MT2-homozygosis. 103,104 Concerning the cord blood of pregnant smokers, whose Cd levels are higher than those of non-smokers, the concentration in the cord blood is positively correlated with the increase in cord jelly, whereas it is negatively associated with the arterial and the umbilical cord diameters (Table 1). On the other hand, it has also been demonstrated that in pregnancies diagnosed with FGR, the MT levels in the cord blood are higher than in those diagnosed with normal fetal growth.…”

Section: Maternal and Cord Bloodmentioning

confidence: 99%

See 1 more Smart Citation

Cadmium exposure during pregnancy and lactation: materno-fetal and newborn repercussions of Cd(ii), and Cd–metallothionein complexes

et al. 2018

View full text Add to dashboard Cite

Cadmium (Cd) is a non-physiological heavy metal that can be harmful at low concentrations. Increasing anthropogenic activities are incrementing the risk of accumulation of this heavy metal in different organs and tissues of the body. In the case of pregnant women, the threat is more serious due to the implications affecting not only their own health but also fetal development as well. Metallothioneins (MTs), small cysteine-rich proteins, are involved in zinc (Zn) and copper homeostasis in mammals but can, however, also bind with Cd if present. The accumulation of Cd in maternal tissues (e.g. placenta, maternal blood, and mammary glands) induces the synthesis of MTs, preferably MT2, in an attempt to sequester the metal to avoid toxicity. The formed Cd-MT complexes will avoid the Cd transport from the placenta to the fetus and end up accumulating in the maternal kidneys. At the same time, high concentrations of MTs will increase the formation of Zn-MT complexes, therefore decreasing the amount of Zn ions available to be transported to the fetus by means of Zn transporters such as ZnT2, ZIP14 and DMT1. Although MTs cannot transport Cd from the mother to the fetus, the divalent DMT1 transporter is suggested to carry the metal to the fetus. As a consequence, the low levels of Zn(ii) in the fetus, together with the presence of Cd(ii) coming from the mother either via the placenta and cord blood or via breast milk induce changes in the fetal development including fetal growth retardation, and low weight or height of the newborn. Likewise, the concentrations of Cd(ii) in the newborn can cause alterations such as cognitive disabilities. In summary, the presence of Cd(ii) in the maternal tissues will induce MT synthesis in an attempt to detoxify these tissues and reduce the possible toxicity of Cd in fetal and newborn tissues.

show abstract

Section: Fetusmentioning

confidence: 99%

Section: Maternal and Cord Bloodmentioning

confidence: 99%

Cadmium exposure during pregnancy and lactation: materno-fetal and newborn repercussions of Cd(ii), and Cd–metallothionein complexes

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Tobacco smoking can affect MT expression in the placenta and subsequent binding, transfer and placental accumulation of related metal ions. However, the relevant literature lacks studies combining smoking-related effects on MT in healthy mother-newborn pairs [23] and antioxidant capacity taking into account the interplay of multiple elements [19,24]. As both antioxidant enzymes and MT share important roles in element physiology and smoking-related toxicology, as well as in the maintenance of pro/antioxidant balance, it is of the outmost significance to follow those parameters simultaneously.…”

Section: Introductionmentioning

confidence: 99%

Cigarette Smoking during Pregnancy: Effects on Antioxidant Enzymes, Metallothionein and Trace Elements in Mother-Newborn Pairs

et al. 2020

Self Cite

View full text Add to dashboard Cite

The effect of maternal smoking as a source of exposure to toxic metals Cd and Pb on superoxide dismutase (SOD) and glutathione peroxidase (GPx) activity, metallothionein (MT), Cd, Pb, Cu, Fe, Mn, Se and Zn concentrations were assessed in maternal and umbilical cord blood and placenta in 74 healthy mother-newborn pairs after term delivery. Sparse discriminant analysis (SDA) was used to identify elements with the strongest impact on the SOD, GPx and MT in the measured compartments, which was then quantified by multiple regression analysis. SOD activity was lower in maternal and cord plasma, and higher in the placenta of smokers compared to non-smokers, whereas GPx activity and MT concentration did not differ between the groups. Although active smoking during pregnancy contributed to higher maternal Cd and Pb concentrations, its contribution to the variability of SOD, GPx or MT after control for other elements identified by SDA was not significant. However, an impaired balance in the antioxidant defence observed in the conditions of relatively low-to-moderate exposure levels to Cd and Pb could contribute to an increased susceptibility of offspring to oxidative stress and risk of disease development later in life. Further study on a larger number of subjects will help to better understand complex interactions between exposure to toxic elements and oxidative stress related to maternal cigarette smoking.

show abstract

“…Metallothionein 2 is a cysteinerich low-weight protein found in the body. Its main function is binding, transfer and organ accumulation of metals [76]. A trace elements and metal enzymes effect interaction of micro-and macroorganism in sepsis [7].…”

mentioning

confidence: 99%

Abdominal Sepsis. Some Genetic-Molecular Mechanisms of Its Occurrence

Kavyn

2020

Galician med. j.

View full text Add to dashboard Cite

Sepsis is a dangerous pathology which is characterized by a high mortality and morbidity in the whole world. Among varieties of sepsis an abdominal sepsis takes the second position. A huge number of scientific investigations, dedicated to sepsis, were done and are being done now. The search for new pathophysiological links of sepsis is ongoing. Studies show that more and more scientists pay attention to the status of genes polymorphism and their influence on the molecular mechanisms of the course of abdominal sepsis, which can help to decide this complex medical problem.

show abstract

Metallothionein 2A gene polymorphism and trace elements in mother-newborn pairs in the Croatian population

Cited by 22 publications

References 49 publications

Cadmium exposure during pregnancy and lactation: materno-fetal and newborn repercussions of Cd(ii), and Cd–metallothionein complexes

Cadmium exposure during pregnancy and lactation: materno-fetal and newborn repercussions of Cd(ii), and Cd–metallothionein complexes

Cigarette Smoking during Pregnancy: Effects on Antioxidant Enzymes, Metallothionein and Trace Elements in Mother-Newborn Pairs

Abdominal Sepsis. Some Genetic-Molecular Mechanisms of Its Occurrence

Contact Info

Product

Resources

About