Metalloproteinases in Restorative Dentistry: An In Silico Study toward an Ideal Animal Model
Simone Gomes de Oliveira,
Nelson Kotowski,
Helio Rodrigues Sampaio-Filho
et al.
Abstract:In dentistry, various animal models are used to evaluate adhesive systems, dental caries and periodontal diseases. Metalloproteinases (MMPs) are enzymes that degrade collagen in the dentin matrix and are categorized in over 20 different classes. Collagenases and gelatinases are intrinsic constituents of the human dentin organic matrix fibrillar network and are the most abundant MMPs in this tissue. Understanding such enzymes’ action on dentin is important in the development of approaches that could reduce dent… Show more
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