Metalloproteinases in non-alcoholic fatty liver disease and their behavior in liver fibrosis

Barchuk, Magalí; Schreier, Laura; Berg, Gabriela; Miksztowicz, Verónica

doi:10.1515/hmbci-2018-0037

Cited by 6 publications

(3 citation statements)

References 34 publications

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“…Toyoda et al [47] reported that mRNA and serum levels of MMP-2 were up-regulated in hepatic steatosis; however, Miele et al [48] found only increased TIMP-1 serum levels. In our laboratory, we recently described a decrease in liver MMP-2 activity in severe fibrosis in comparison to non- to moderate fibrosis stages and no differences in MMP-9 activity in patients with NAFLD [49]. In accordance, Hemman et al [50] previously reported that in activated HSCs, TIMP-1 expression is increased, and concomitantly MMPs activity is reduced, leading to protein accumulation.…”

Section: The Role Of Mmps In Different Tissuessupporting

confidence: 56%

Behavior of Metalloproteinases in Adipose Tissue, Liver and Arterial Wall: An Update of Extracellular Matrix Remodeling

Berg

Barchuk

Miksztowicz

2019

Cells

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Extracellular matrix (ECM) remodeling is required for many physiological and pathological processes. Metalloproteinases (MMPs) are endopeptidases which are able to degrade different components of the ECM and nucleus matrix and to cleave numerous non-ECM proteins. Among pathological processes, MMPs are involved in adipose tissue expansion, liver fibrosis, and atherosclerotic plaque development and vulnerability. The expression and the activity of these enzymes are regulated by different hormones and growth factors, such as insulin, leptin, and adiponectin. The controversial results reported up to this moment regarding MMPs behavior in ECM biology could be consequence of the different expression patterns among species and the stage of the studied pathology. The aim of the present review was to update the knowledge of the role of MMPs and its inhibitors in ECM remodeling in high incidence pathologies such as obesity, liver fibrosis, and cardiovascular disease.

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Section: The Role Of Mmps In Different Tissuessupporting

confidence: 56%

Behavior of Metalloproteinases in Adipose Tissue, Liver and Arterial Wall: An Update of Extracellular Matrix Remodeling

Berg

Barchuk

Miksztowicz

2019

Cells

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“…MMP2 and MMP9 are gelatinases responsible for the degradation of extracellular matrix (ECM) proteins which play a key role in the pathogenesis of NAFLD, steatosis, fibrosis, and cirrhosis (Theret et al., 1999). The expression and proteolytic activity of MMP2 and MMP9 are closely regulated by the endogenous activator MT1‐MMP and the inhibitors TIMP1 and TIMP2 (Barchuk et al., 2018). Our findings indicated that MTO attenuates HFD‐induced hepatic fibrosis by reduction of MMP2, MMP9, and MT1‐MMP expressions in the liver.…”

Section: Discussionmentioning

confidence: 99%

Milk thistle seed cold press oil attenuates markers of the metabolic syndrome in a mouse model of dietary‐induced obesity

et al. 2020

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Milk thistle cold press oil (MTO) is an herbal remedy derived from Silybum marianum which contains a low level of silymarin and mixture of polyphenols and flavonoids. The effect of MTO on the cardiovascular and metabolic complications of obesity was studied in mice that were fed a high-fat diet (HFD) for 20 weeks and treated with MTO for the final 8 weeks of the diet. MTO treatment attenuated HFD-induced obesity, fasting hyperglycemia, hypertension, and induced markers of mitochondrial fusion and browning of white adipose. Markers of inflammation were also attenuated in both adipose and the liver of MTO-treated mice. In addition, MTO resulted in the improvement of liver fibrosis. These results demonstrate that MTO has beneficial actions to attenuate dietary obesity-induced weight gain, hyperglycemia, hypertension, inflammation, and suggest that MTO supplementation may prove beneficial to patients exhibiting symptoms of metabolic syndrome. Practical applications Natural supplements are increasingly being considered as potential therapies for many chronic cardiovascular and metabolic diseases. Milk thistle cold press oil (MTO) is derived from Silybum marianum which is used as a dietary supplement in different parts of the world. The results of the present study demonstrate that MTO supplementation normalizes several metabolic and cardiovascular complications arising from dietary-induced obesity. MTO supplementation also had anti-inflammatory actions in the adipose as well as the liver. These results suggest that supplementation of MTO into the diet of obese individuals may afford protection against the worsening of cardiovascular and metabolic disease and improve inflammation and liver fibrosis.

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“…[ 86 , 87 ]. Thus, activation of TIMPs causes an alteration of the balance between metalloproteinases and their inhibitors, resulting in the deposition and impairment of the ECM architecture [ 88 ]. However, an increase in proMMP-2, and also to a lesser extent active MMP-2, suggests a continuous rotation of the active matrix even in advanced liver fibrosis.…”

Section: Ecm In Mafldmentioning

confidence: 99%

Molecular Advances in MAFLD—A Link between Sphingolipids and Extracellular Matrix in Development and Progression to Fibrosis

Kołakowski

Dziemitko

Chmielecka

et al. 2022

IJMS

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Metabolic-Associated Fatty Liver Disease (MAFLD) is a major cause of liver diseases globally and its prevalence is expected to grow in the coming decades. The main cause of MAFLD development is changed in the composition of the extracellular matrix (ECM). Increased production of matrix molecules and inflammatory processes lead to progressive fibrosis, cirrhosis, and ultimately liver failure. In addition, increased accumulation of sphingolipids accompanied by increased expression of pro-inflammatory cytokines in the ECM is closely related to lipogenesis, MAFLD development, and its progression to fibrosis. In our work, we will summarize all information regarding the role of sphingolipids e.g., ceramide and S1P in MAFLD development. These sphingolipids seem to have the most significant effect on macrophages and, consequently, HSCs which trigger the entire cascade of overproduction matrix molecules, especially type I and III collagen, proteoglycans, elastin, and also tissue inhibitors of metalloproteinases, which as a result cause the development of liver fibrosis.

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Metalloproteinases in non-alcoholic fatty liver disease and their behavior in liver fibrosis

Cited by 6 publications

References 34 publications

Behavior of Metalloproteinases in Adipose Tissue, Liver and Arterial Wall: An Update of Extracellular Matrix Remodeling

Behavior of Metalloproteinases in Adipose Tissue, Liver and Arterial Wall: An Update of Extracellular Matrix Remodeling

Milk thistle seed cold press oil attenuates markers of the metabolic syndrome in a mouse model of dietary‐induced obesity

Molecular Advances in MAFLD—A Link between Sphingolipids and Extracellular Matrix in Development and Progression to Fibrosis

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