Metalloproteinases in Corneal Diseases

Sakimoto, Tohru; Sawa, Mitsuru

doi:10.1097/ico.0b013e318269ccd0

Cited by 57 publications

(44 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The ultrastructure studies have revealed altered lamellar collagen organisation, collagen fibril thinning, decreased epithelial hypoplasia, Bowman’s layer breaks and stromal thinning in the ectatic region of the cornea 23 24. Functional association between collagen degradation process (characteristic of ectasia) and inflammation has been reported 25. Other factors such as pregnancy and eye rubbing that serve as triggers for PLE also suggest a plausible inflammatory component to the pathogenesis of PLE.…”

Section: Discussionmentioning

confidence: 92%

In vivo confocal microscopy and tear cytokine analysis in post-LASIK ectasia

et al. 2017

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 92%

In vivo confocal microscopy and tear cytokine analysis in post-LASIK ectasia

et al. 2017

View full text Add to dashboard Cite

show abstract

“…41 A study showed clusters of disrupted tight junction proteins, occludin and claudin, in conjunction with increased MMP-2 immunoreactivity in samples of superficial cornea epithelium obtained at night in Xenopus laevis. 42 While this mechanism for corneal epithelial desquamation has not been confirmed in human corneas, increased levels of MMP-2 and -9 have been found in cornea epithelium and tear fluid obtained from eyes with recurrent corneal epithelial erosion, 43,44 and increased proand active forms of MMP-9 have also been found in tears sampled from the closed eye during sleep when recurrent erosions typically occur while tear production and clearance are decreased. 45 There is mounting evidence that MMPs contribute to the altered cornea barrier function that is observed in dry eye.…”

mentioning

confidence: 99%

Matrix metalloproteinase-9 in the pathophysiology and diagnosis of dry eye syndrome

Pflugfelder¹,

Bian²,

Paiva³

2017

MNM

View full text Add to dashboard Cite

Dry eye and tear dysfunction are common ocular disorders that cause cornea barrier disruption resulting in a poorly lubricated and irregular cornea epithelium, eye irritation and blurred vision. Increased levels and activities of matrix metalloproteinases (MMPs), particularly MMP-9, have been detected in the tears and ocular surface epithelial and inflammatory cells in dry eye. MMPs have been found to participate in disruption of tight junctions in the apical cornea epithelium leading to their accelerated desquamation and barrier disruption. This review summarizes evidence showing the contribution of MMPs to dry eye pathogenesis and their roles as biomarkers and therapeutic targets. Keywords: matrix metalloproteinase, dry eye, keratitis sicca, cornea, barrier function, Sjögren syndrome Dry eye overviewDry eye and tear dysfunction are common ocular disorders that cause cornea barrier disruption resulting in a poorly lubricated and irregular cornea epithelium, eye irritation and blurred vision. It affects millions of people worldwide and is one of the most frequent conditions for which patients seek eye care.1 Aging and female sex are significant risk factors for dry eye which increases in prevalence around the fifth decade, with further increase every decade thereafter.2-13 Prevalence of dry eye varies from 2% to 50%, depending on the population studied and the diagnostic criteria for dry eye (symptom questionnaire vs. objective signs). [1][2][3]6,7,[9][10][11][14][15][16][17][18][19][20][21][22][23] There is scarce information about the natural history of dry eye, but there is a recognized disconnection between signs and symptoms; patients tend to be more symptomatic at early stages.24,25 Dry eye causes corneal irregularity [26][27][28] and decreases functional vision by altering contrast sensitivity [29][30][31] and, therefore, decreases quality of life with a significant burden on the individual as well as the society. 23,[32][33][34][35] A meta-analysis of 22 published studies showed increased odds ratio for depression and anxiety in patients with ocular Sjögren syndrome (SS). 36 There is increased evidence that dry eye is an inflammatory disease, and this review will focus on matrix metalloproteinases (MMPs) and their role in the pathogenesis of dry eye. Cornea barrier disruption is a feature of dry eyeAs the principal lens of the eye, the cornea has unique features to maintain its transparency and smooth surface that include a lack of blood vessels and a multilayered stratified, non-cornifying epithelium. The differentiated apical epithelial cells produce

show abstract

“…3 Cultured corneal fibroblasts produce MMP-1, -2, and -3, 24 and increased levels of these MMPs have been detected in melted corneal specimens from individuals with rheumatoid arthritis or ocular cicatricial pemphigoid 10 as well as in tear fluid of patients with corneal melting or recurrent corneal erosion. 25 MMP-1 is the collagenolytic enzyme that is largely responsible for the degradation of type I collagen, the major structural protein of the corneal stroma. The gelatinase MMP-2 degrades mostly type IV collagen and is thought to contribute to degradation of the epithelial basement membrane that promotes corneal ulceration.…”

Section: Discussionmentioning

confidence: 99%