“…ADAM10 has been shown to act as the ␣-secretase in vivo, preventing amyloid plaque formation and hippocampal defects in a mouse model of Alzheimer's disease [47]. A soluble form of ADAM12 is reported as a predictor of preeclampsia [48], and single nucleotide polymorphisms in ADAM33 are associated with asthma susceptibility and psoriasis [49,50]. Furthermore, many ADAMs, including ADAM8, ADAM9, ADAM10, ADAM12, ADAM15, ADAM17, ADAM19, and ADAM28, have been reported to be expressed in human malignant tumors.…”