Metalloporphyrins in Drug and Pesticide Catalysis as Powerful Tools to Elucidate Biotransformation Mechanisms

Zanatta, Lucas D.; Barbosa, Isaltino A.; Filho, Paulo C. de Sousa; Zanardi, Fabrício B.; Bolzon, Lucas B.; Serra, Osvaldo Antônio; Iamamoto, Yassuko

doi:10.2174/1570193x13666160609122754

Cited by 14 publications

(11 citation statements)

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“…Then, the formation of oxo species occurs after H 2 O elimination and oxidation of the central metal [27,28]. In protic solvents, these intermediates can then react with drugs and promote a series of oxidative reactions, namely epoxidations, hydroxylation, dealkylation, deamination, decarbonylation, N-or S-oxidation, among others [29]. Scheme 3.…”

Section: Oxidation Mechanisms Using Tetrapyrrolic Macrocycle-based Catalystsmentioning

confidence: 99%

Oxidative Degradation of Pharmaceuticals: The Role of Tetrapyrrole-Based Catalysts

et al. 2021

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Nowadays, society’s widespread consumption of pharmaceutical drugs and the consequent accumulation of such compounds or their metabolites in effluents requires the development of efficient strategies and systems that lead to their effective degradation. This can be done through oxidative processes, in which tetrapyrrolic macrocycles (porphyrins, phthalocyanines) deserve special attention since they are among the most promising degradation catalysts. This paper presents a review of the literature over the past ten years on the major advances made in the development of oxidation processes of pharmaceuticals in aqueous solutions using tetrapyrrole-based catalysts. The review presents a brief discussion of the mechanisms involved in these oxidative processes and is organized by the degradation of families of pharmaceutical compounds, namely antibiotics, analgesics and neurological drugs, among others. For each family, a critical analysis and discussion of the fundamental roles of tetrapyrrolic macrocycles are presented, regarding both photochemical degradative processes and direct oxidative chemical degradation.

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Section: Oxidation Mechanisms Using Tetrapyrrolic Macrocycle-based Catalystsmentioning

confidence: 99%

Oxidative Degradation of Pharmaceuticals: The Role of Tetrapyrrole-Based Catalysts

et al. 2021

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“…The role of the tetrapyrrolic macrocycle as a privileged ligand for the preparation of metal complexes was soon recognized, and in 1978, the periodic table of metalloporphyrins [1] (Figure 1) already included almost all the metals of the periodic table. Inspired by their roles in nature, the research involving metalloporphyrins is in constant development, the hundreds of papers/per year involving metalloporphyrins and their distribution among many science categories (Figure 2) illustrating very well the interest in these compounds and their applications in such diverse areas as catalysis, medicine, imaging, and materials [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Modern Methods for the Sustainable Synthesis of Metalloporphyrins

2021

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Metalloporphyrins are involved in many and diverse applications that require the preparation of these compounds in an efficient manner, which nowadays, also involves taking into consideration sustainability issues. In this context, we use ball milling mechanochemistry and sonochemistry for the rational development of synthetic strategies for the sustainable preparation of metalloporphyrins. Zinc, copper, cobalt and palladium complexes of hydrophobic porphyrins were obtained in high yields and under mechanical action with a moderate excess of the metal salt, without any solvent or additive. Sonochemistry prove to be a good alternative for the preparation of metal complexes of water-soluble porphyrins in good yields and short reaction times. Both strategies have good sustainability scores, close to the ideal values, which is useful in comparing and helping to choose the more adequate method.

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“…pollutants and drugs) in biological systems. [1][2][3][4][5][6][7][8][9] In the attempt to mimic the CYP reactions, many researchers use synthetic models called 'bioinspired catalysts' to reproduce reactions catalysed by these enzymes. While in nature, metalloenzyme-catalysed oxidations oen exhibit exquisite substrate specicity, as well as regioselectivity and/or stereoselectivity, synthetic bioinspired or biomimetic systems may have broader substrate scope and tunable selectivity, which make them challenging protagonists of near-future environmentally friendly catalytic chemistry.…”

Section: Introductionmentioning

confidence: 99%

Rhodamine B oxidation promoted by P450-bioinspired Jacobsen catalysts/cellulose systems

Bolzon¹,

Bindeiro²,

Souza³

et al. 2021

RSC Adv.

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Metalloporphyrins in Drug and Pesticide Catalysis as Powerful Tools to Elucidate Biotransformation Mechanisms

Cited by 14 publications

References 0 publications

Oxidative Degradation of Pharmaceuticals: The Role of Tetrapyrrole-Based Catalysts

Oxidative Degradation of Pharmaceuticals: The Role of Tetrapyrrole-Based Catalysts

Modern Methods for the Sustainable Synthesis of Metalloporphyrins

Rhodamine B oxidation promoted by P450-bioinspired Jacobsen catalysts/cellulose systems

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