Metallomacrocycle or 1D chain: Synthesis, structures, and antifungal activities of zinc(II) and silver(I) complexes based on two reduced Schiff base ligands

He, Shan-Xian; Yu, Haijiang; Huang, Chao; Chen, Dongmei; Zhu, Bi‐Xue

doi:10.1016/j.molstruc.2023.136073

Cited by 4 publications

(2 citation statements)

References 54 publications

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“…The antifungal activity of various Schiff-base complexes of metal ions like Cu 12 , Co 13 , Zn 14 , Fe 15 , Mn 8 have been studied, among which Cu coordinated with Schiff-base ligands is a new potential antifungal agent to expand the explorations. The following reports are on the antifungal ability of Cu Schiff-base complex of 2-((E)-(2–hydroxyethylimino)methyl)-1-naptaphenol 9 , Cu(II) complexes of porphyrin core 13 , thiophene-derived Schiff base complex of Cu (II) 16 , antipyrine derived-Schiff base Cu complex 17 , Cu(II) complexes with terpene derivatives of ethylenediamine 18 , Cu(II) complex containing NO donor bidentate Schiff base 19 , thiazole Schiff base complex of Cu 20 , 4,6-dihydroxy-1,3-phenylenediethanone Schiff base complex of Cu derived from 21 , and Cu(II) complex of Schiff-base based on glycine and phenylalanine 19 .…”

Section: Introductionmentioning

confidence: 99%

Antifungal activity of Fe3O4@SiO2/Schiff-base/Cu(II) magnetic nanoparticles against pathogenic Candida species

Azadi,

Azizipour,

Amani

et al. 2024

Sci Rep

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The antifungal efficacy and cytotoxicity of a novel nano-antifungal agent, the Fe3O4@SiO2/Schiff-base complex of Cu(II) magnetic nanoparticles (MNPs), have been assessed for targeting drug-resistant Candida species. Due to the rising issue of fungal infections, especially candidiasis, and resistance to traditional antifungals, there is an urgent need for new therapeutic strategies. Utilizing Schiff-base ligands known for their broad-spectrum antimicrobial activity, the Fe3O4@SiO2/Schiff-base/Cu(II) MNPs have been synthesized. The Fe3O4@SiO2/Schiff-base/Cu(II) MNPs was characterized by Fourier Transform-Infrared Spectroscopy (FT-IR), X-ray Diffraction (XRD), Transmission Electron Microscopy (TEM), Scanning Electron Microscopy (SEM), Dynamic Light Scattering (DLS), Energy-dispersive X-ray (EDX), Vibrating Sample Magnetometer (VSM), and Thermogravimetric analysis (TGA), demonstrating successful synthesis. The antifungal potential was evaluated against six Candida species (C. dubliniensis, C. krusei, C. tropicalis, C. parapsilosis, C. glabrata, and C. albicans) using the broth microdilution method. The results indicated strong antifungal activity in the range of 8–64 μg/mL with the lowest MIC (8 μg/mL) observed against C. parapsilosis. The result showed the MIC of 32 μg/mL against C. albicans as the most common infection source. The antifungal mechanism is likely due to the disruption of the fungal cell wall and membrane, along with increased reactive oxygen species (ROS) generation leading to cell death. The MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay for cytotoxicity on mouse L929 fibroblastic cells suggested low toxicity and even enhanced cell proliferation at certain concentrations. This study demonstrates the promise of Fe3O4@SiO2/Schiff-base/Cu(II) MNPs as a potent antifungal agent with potential applications in the treatment of life-threatening fungal infections, healthcare-associated infections, and beyond.

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Section: Introductionmentioning

confidence: 99%

Antifungal activity of Fe3O4@SiO2/Schiff-base/Cu(II) magnetic nanoparticles against pathogenic Candida species

Azadi,

Azizipour,

Amani

et al. 2024

Sci Rep

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“…Some important fungicides with pyridine skeletons have been commercialized (Figure B). Furthermore, novel pyridine derivatives as potential fungicides are continuously discovered. ,, …”

Section: Introductionmentioning

confidence: 99%

Novel Pyrido[4,3-d]pyrimidine Derivatives as Potential Sterol 14α-Demethylase Inhibitors: Design, Synthesis, Inhibitory Activity, and Molecular Modeling

Yan,

Xie,

Jiang

et al. 2024

J. Agric. Food Chem.

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pyrimidine analogs were designed, synthesized, and characterized. The crystal structures for compounds 2c and 4f were measured by means of X-ray diffraction of single crystals. The bioassay results showed that most target compounds exhibited good fungicidal activities against Pyricularia oryzae, Rhizoctonia cerealis, Sclerotinia sclerotiorum, Botrytis cinerea, and Penicillium italicum at 16 μg/mL. Compounds 2l, 2m, 4f, and 4g possessed better fungicidal activities than the commercial fungicide epoxiconazole against B. cinerea. Their half maximal effective concentration (EC 50 ) values were 0.191, 0.487, 0.369, 0.586, and 0.670 μg/mL, respectively. Furthermore, the inhibitory activities of the bioactive compounds were determined against sterol 14α-demethylase (CYP51). The results displayed that they had prominent activities. Compounds 2l, 2m, 4f, and 4g also showed better inhibitory activities than epoxiconazole against CYP51. Their half maximal inhibitory concentration (IC 50 ) values were 0.219, 0.602, 0.422, 0.726, and 0.802 μg/mL, respectively. The results of molecular dynamics (MD) simulations exhibited that compounds 2l and 4f possessed a stronger affinity to CYP51 than epoxiconazole.

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Hydrothermal preparation, crystal structure, Hirshfeld surface analysis, photophysical properties and antifungal activity of a series of complexes assembled by 5-bromo-2-(carboxymethoxy)benzoic acid ligands

Xiong,

Yi,

Xiao

et al. 2024

Journal of Molecular Structure

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Metallomacrocycle or 1D chain: Synthesis, structures, and antifungal activities of zinc(II) and silver(I) complexes based on two reduced Schiff base ligands

Cited by 4 publications

References 54 publications

Antifungal activity of Fe3O4@SiO2/Schiff-base/Cu(II) magnetic nanoparticles against pathogenic Candida species

Antifungal activity of Fe3O4@SiO2/Schiff-base/Cu(II) magnetic nanoparticles against pathogenic Candida species

Novel Pyrido[4,3-d]pyrimidine Derivatives as Potential Sterol 14α-Demethylase Inhibitors: Design, Synthesis, Inhibitory Activity, and Molecular Modeling

Hydrothermal preparation, crystal structure, Hirshfeld surface analysis, photophysical properties and antifungal activity of a series of complexes assembled by 5-bromo-2-(carboxymethoxy)benzoic acid ligands

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