Metallodrugs in cancer nanomedicine

Peña, Quim; Wang, Alec; Zaremba, Orysia; Shi, Yang; Scheeren, Hans W.; Metselaar, Josbert M.; Kießling, Fabian; Pallares, Roger M.; Wuttke, Stefan; Lammers, Twan

doi:10.1039/d1cs00468a

Cited by 106 publications

(88 citation statements)

References 447 publications

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“…Hybrid nanocomposites have great research value in pharmacology and medicine because drug delivery systems based on nanocomposites are very promising for targeted therapies that can deliver therapeutic agents with improved properties to their destination while minimizing side effects. 113,114 Because the composition of nanocomposites is oen very different in their structure as well as physical and chemical properties, their combinations and synergies offer a great deal of possibilities in terms of function and biological activity. 115 POMs have proven to be ideal building blocks for nanocomposites due to their unique range of properties and ability to form clusters ranging in size from a few angstroms to nanometers.…”

Section: Hybrid Nanocompositesmentioning

confidence: 99%

Polyoxometalate-based nanocomposites for antitumor and antibacterial applications

Chang

Chen

et al. 2022

Nanoscale Adv.

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Section: Hybrid Nanocompositesmentioning

confidence: 99%

Polyoxometalate-based nanocomposites for antitumor and antibacterial applications

Chang

Chen

et al. 2022

Nanoscale Adv.

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“…Chemotherapy is one of the most classic methods of cancer treatment [ 1 ]. However, insufficient local drug concentration leads to poor chemotherapy effect or even drug resistance [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

ROS triggered local delivery of stealth exosomes to tumors for enhanced chemo/photodynamic therapy

et al. 2022

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Background Exosomes are recognized as effective platforms for targeted delivery for their high physicochemical stability and biocompatibility. However, most of the exosomes are inevitably and rapidly cleared by mononuclear phagocytic system (MPS) during cancer therapy. How to engineer exosome to enhance the delivery efficiency is being intensively explored. In this study, we have constructed mPEG2000-TK-CP05 decorated exosomes as effective delivery platforms to achieve enhanced photodynamic/chemical cancer therapy. Results Exosomes were coated with CP05-TK-mPEG2000, in which CP05 is a peptide with high affinity to exosomal CD63 and TK could be cleaved by ROS. The resulted exosomes, namely stealth Exo, were electroporated to load RB (photosensitizer Rose Bengal) and Dox (Doxorubicin). We verified that the Stealth Exo@RB (Stealth Exo additionally loaded with RB) could escape MPS while accumulate in the tumor region efficiently in the xenograft model when laser irradiation conducted locally. Additionally, we revealed that the Stealth Exo serves as an efficient platform for Dox delivery. Dox, together with the RB mediated photodynamic therapy induce tumor cell damage synergistically in the tumor region. Moreover, the proposed switchable stealth exosomes minimized the dose of toxic Dox and thus allowed robust tumor immune response. Conclusions Our results indicated that the proposed Stealth Exo greatly improves both the accessibility and efficiency of drug delivery, with minimal chemical or genetic engineering. The proposed Stealth Exo serve as a promising and powerful drug delivery nanoplatform in cancer treatment.

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“…Ru(II) polypyridyl complexes are characterized by a variety of electronic configurations of the metal in the excited state accessible with near-infrared and visible light. Furthermore, configurations may be tunable by ligand tailoring [ 16 ]. Ruthenium-based metal complexes and ruthenium nanoparticles have also found application in photodynamic antimicrobial studies [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

The Enhancement of Antimicrobial Photodynamic Therapy of Escherichia Coli by a Functionalized Combination of Photosensitizers: In Vitro Examination of Single Cells by Quantitative Phase Imaging

Pietrowska

Hołowacz

Ulatowska-Jarża

et al. 2022

IJMS

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The prevention of biofilm formation is crucial for the limitation of bacterial infections typically associated with postoperative infections, complications in bedridden patients, and a short-term prognosis in affected cancer patients or mechanically ventilated patients. Antimicrobial photodynamic therapy (aPDT) emerges as a promising alternative for the prevention of infections due to the inability of bacteria to become resistant to aPDT inactivation processes. The aim of this study was to demonstrate the use of a functionalized combination of Chlorin e6 and Pheophorbide as a new approach to more effective aPDT by increasing the accumulation of photosensitizers (PSs) within Escherichia coli cells. The accumulation of PSs and changes in the dry mass density of single-cell bacteria before and after aPDT treatment were investigated by digital holotomography (DHT) using the refractive index as an imaging contrast for 3D label-free live bacteria cell imaging. The results confirmed that DHT can be used in complex examination of the cell–photosensitizer interaction and characterization of the efficiency of aPDT. Furthermore, the use of Pheophorbide a as an efflux pomp inhibitor in combination with Chlorin e6 increases photosensitizers accumulation within E. coli and overcomes the limited penetration of Gram-negative cells by anionic and neutral photosensitizers.

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Metallodrugs in cancer nanomedicine

Abstract: Bridging inorganic medicinal chemistry and nanomedicine in cancer therapy: nanoformulations to improve the clinical translation of metallodrugs.

Cited by 106 publications

References 447 publications

Polyoxometalate-based nanocomposites for antitumor and antibacterial applications

Polyoxometalate-based nanocomposites for antitumor and antibacterial applications

ROS triggered local delivery of stealth exosomes to tumors for enhanced chemo/photodynamic therapy

The Enhancement of Antimicrobial Photodynamic Therapy of Escherichia Coli by a Functionalized Combination of Photosensitizers: In Vitro Examination of Single Cells by Quantitative Phase Imaging

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