Abstract:Objective To report our experience with metallic self-quality of life was improved and symptoms such as loin pain were ameliorated. Renal function was pre-expanding stents in the palliative care of patients with ureteric obstruction caused by advanced pelvic served; the mean serum creatinine level before and after stenting was 636 and 263 mmol/L, respectively). malignancy.
Patients and methods Seven patients (five men and twoThe mean duration of stent patency was 9 months. Of the five patients who subsequently… Show more
“…In vitro studies with poly(ethylene oxide)/polyurethane composite hydrogel (Aquavene) showed promising results, with superior resistance to encrustation and intraluminal blockage over 24 weeks [18]. Other materials used recently as permanently implanted stents for relieving malignant obstructions and ureteral strictures are metallic, super-alloy, titanium or nickel/titanium stents designed to be covered by normal urothelium [1,29,40,42]. However, the extent to which epithelialization takes place remains to be seen.…”
Section: Urological Biomaterials and Biocompatibilitymentioning
confidence: 99%
“…In the last few years, several clinical studies have focused on assessment of new implantable stents, which are expandable and permanent [1,29,30,40,42]. Time will tell if these can remain in the host without becoming a nidus for infections, encrustation, toxicity, and other adverse eects.…”
This review focuses on technological advances and relevant research related to ureteral stents. The importance of physical and chemical biomaterial type, biocompatibility, material coatings such as hydrogels, and infection related to indwelling ureteral stents are discussed. Recent in vitro and in vivo research has focused on materials that will reduce encrustation and bacterial biofilm formation. The adsorption of antimicrobials onto devices holds promise of reducing infection rates, but multidrug resistant bacteria, short leaching times and adverse side effects make it essential that alternative strategies be investigated. Just so, encrustation limits the long-term use of urinary materials, and a better understanding of factors involved in encrustation are needed to reduce the problem.
“…In vitro studies with poly(ethylene oxide)/polyurethane composite hydrogel (Aquavene) showed promising results, with superior resistance to encrustation and intraluminal blockage over 24 weeks [18]. Other materials used recently as permanently implanted stents for relieving malignant obstructions and ureteral strictures are metallic, super-alloy, titanium or nickel/titanium stents designed to be covered by normal urothelium [1,29,40,42]. However, the extent to which epithelialization takes place remains to be seen.…”
Section: Urological Biomaterials and Biocompatibilitymentioning
confidence: 99%
“…In the last few years, several clinical studies have focused on assessment of new implantable stents, which are expandable and permanent [1,29,30,40,42]. Time will tell if these can remain in the host without becoming a nidus for infections, encrustation, toxicity, and other adverse eects.…”
This review focuses on technological advances and relevant research related to ureteral stents. The importance of physical and chemical biomaterial type, biocompatibility, material coatings such as hydrogels, and infection related to indwelling ureteral stents are discussed. Recent in vitro and in vivo research has focused on materials that will reduce encrustation and bacterial biofilm formation. The adsorption of antimicrobials onto devices holds promise of reducing infection rates, but multidrug resistant bacteria, short leaching times and adverse side effects make it essential that alternative strategies be investigated. Just so, encrustation limits the long-term use of urinary materials, and a better understanding of factors involved in encrustation are needed to reduce the problem.
“…Gort et al [20] reported the first use of a metallic ureteric stent and since then a variety of stents have entered urological practice, e.g. wallstents, PalmazSchatz and Accuflex stents [21] . However, these are all meshed stents and their usage is hindered by re-occlusion due to endothelial hyperplasia, and tumour in-growth through the meshwork making removal virtually impossible [22,23] .…”
Introduction: The Memokath 051™ is a semipermanent inert metal alloy ureteric stent which can bridge strictures and, compared to double J stents, causes less bladder irritation and pain, is more resistant to external compression forces and may be more effective in patients with malignant ureteric obstruction. We present our experience with this novel stent in such cases. Methods: All suitable patients referred to us with malignancy-associated ureteric strictures over a 4-year period had ureteric Memokath 051™ stents inserted. Data on aetiology and position of the strictures as well as length of the Memokath stents used and their efficacy and complications were recorded prospectively. Results: 42 ureteric Memokath 051™ stents were inserted in 37 patients (mean age 64 years). 40.5% of strictures were related to gynaecological cancer, 21% to bowel cancer, 14% were post radiation, 14% occurred in prostate cancer patients and 9.5% were found in other cancers. The mean follow-up was 22 months (range 5–60 months). The main complications were stent migrations in 5, urinary tract infections in 3 and blockage of stent due to progressive transitional cell carcinoma of the ureter in 2 cases. Conclusion: Memokath 051™ ureteric stents are safe, effective and durable in the long-term treatment of malignant strictures.
“…Patency was maintained for 6 months. Pandian et al [10] reported their early experience with antegrade placement of the Memotherm stent which does not have the property of softening and cannot be removed. Wallstents have also been described in treating ureteral strictures.…”
Introduction: Memokath 051® represents a nickel-titanium stent that has been used to treat patients with incurable ureteral strictures. In the current study we present our experience in using this technique. Materials and Methods: Between 2003 and 2008, 19 metallic stents were placed in 13 patients. All of them had been previously treated by using JJ stents or dilatation. The etiology was benign in 10, while in 3 patients malignancy was involved. The mean age was 60.7 years. Mean stricture length was 3.2 cm while the median stent length was 6 cm. No severe complications were noticed postoperatively. Mean follow-up was 14.3 months. Results: Six patients (46%) experienced a satisfactory result after first insertion. Stent migration was observed in 6 patients and in 3 it was replaced successfully. One patient was offered a simple nephrectomy due to a poorly functioning kidney. Eventually, 10 of 13 patients (77%) had a successful outcome after the final stent insertion. Conclusion: Memokath stents suggest a possible alternative in treating chronic/recurrent ureteral strictures. Their most important disadvantage seems to be migration. Their role in endourological practice remains to be validated.
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