Metallic Nanoparticles: Potential Antimicrobial and Therapeutic Agents

Jamdagni, Pragati; Sidhu, Parveen Kaur; Khatri, Poonam; Nehra, Kiran; Rana, J. S.

doi:10.1007/978-981-10-4702-2_9

Cited by 13 publications

(19 citation statements)

References 112 publications

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“…AgNPs play a major role in disruption of cell wall and plasma membrane of target microorganisms, thereby, leading to cavity formation and electrolyte imbalance [45, 46]. The ruptured membrane allows for better penetration of fungicides inside the cells and combined effects of silver ions on DNA, RNA, and proteins [47, 48] and fungicides led to improved inhibition of fungal targets.…”

Section: Resultsmentioning

confidence: 99%

Comparative study of antifungal effect of green and chemically synthesised silver nanoparticles in combination with carbendazim, mancozeb, and thiram

Jamdagni

Rana

Khatri

2018

IET nanobiotechnol.

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This study reports synthesis and characterisation of silver nanoparticles and their effect on antifungal efficacy of common agricultural fungicides. Silver nanoparticles were synthesised using biological and chemical reduction methods employing Elettaria cardamomum leaf extract and sodium citrate, respectively. Nanoparticles were then characterised using UV-Visible spectroscopy, X-ray diffraction (XRD), transmission electron microscopy, and dynamic light scattering (DLS). While XRD assigned particles size of 31.86 nm for green and 41.91 nm for chemical silver nanoparticles with the help of the Debye-Scherrer formula, DLS specified monodisperse nature of both suspensions. Nanoparticles were tested individually and in combination with fungicides (carbendazim, mancozeb, and thiram) against fungal phytopathogens. Silver nanoparticles exhibited good antifungal activity and minimum inhibitory concentration (MIC) was observed in the range of 8-64 µg/ml. Also, they positively influenced the efficacy of fungicides. The mean MIC value (mean ± SD) for combination of all three fungicides with green AgNPs was 1.37 ± 0.6 µg/ml and for chemical AgNPs was 1.73 ± 1.0 µg/ml. Hence, it could be concluded that green AgNPs performed better than chemical AgNPs. Synergy was observed between green AgNPs and fungicides against Fusarium oxysporum. In conclusion, this study reports synthesis of monodisperse silver nanoparticles which serve as efficient antifungal agents and also enhance the fungicidal action of reported agricultural fungicides in combination studies.

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Section: Resultsmentioning

confidence: 99%

Comparative study of antifungal effect of green and chemically synthesised silver nanoparticles in combination with carbendazim, mancozeb, and thiram

Jamdagni

Rana

Khatri

2018

IET nanobiotechnol.

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“…Ions released by NPs upon contact with the cell wall will inactivate enzymes and cellular proteins by reacting with their thiol groups, interrupting the metabolic actions, and causing the formation of ROS [34]. Different ions exhibit different properties.…”

Section: Disruption Of Cell Walls and Cell Membranesmentioning

confidence: 99%

“…On the other hand, enzymes are a class of proteins that catalyze diverse biochemical reactions by elevating the rate of reaction in the cells and are crucial in controlling biological homeostasis in living organisms [34]. The blocking of enzyme activities is known as enzyme inhibition and it is either reversible or irreversible.…”

Section: Inhibition Of Proteins and Enzymesmentioning

confidence: 99%

Current approaches for the exploration of antimicrobial activities of nanoparticles

Rosli

Teow

Mahmoudi

2021

Science and Technology of Advanced Materials

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is currently pursuing a master's degree at Universiti Kebangsaan Malaysia (UKM). Her research focuses on the antimicrobial of nanoparticles for application in the industry. Dr. Teow Yeit Haan is a senior lecturer at UKM. Her expertise includes membrane synthesis and characterization, membrane application for water purification and wastewater treatment, membrane fouling, water disinfection technology, and adsorption. She had published more than 44 research articles, 22 conference proceedings, and 3 book chapters. Dr. Ebrahim Mahmoudi is working as a senior lecturer at UKM. He is researching separation and purification using polymeric membranes and membrane bioreactors. Current Approaches for the Exploration of Antimicrobial Activities of NanoparticlesInfectious diseases of bacterial and viral origins contribute to substantial mortality worldwide. Collaborative efforts have been underway between academia and the industry to develop technologies for a more effective treatment for such diseases. With their utility in various industrial applications, nanoparticles (NPs) offer promising potential as antimicrobial agents against bacterial and viral infections. NPs have been established to possess potent antimicrobial activities against various types of pathogens due to their unique characteristics and cell-damaging ability through several mechanisms. The recent accepted antimicrobial mechanisms possess by NPs include metal ion release, oxidative stress induction, and non-oxidative mechanisms. Another merit of NPs lies in the low likelihood of the development of microbial tolerance towards NPs,given the multiple simultaneous mechanisms of action against the pathogens targeting numerous gene mutations in those pathogens. Moreover, NPs provide a fascinating opportunity to curb microbial growth before infections: this outstanding feature has led to their utilization as active antimicrobial agents in different industrial applications, e.g. the coating of medical devices, incorporation in food packaging, promoting wound healing, and encapsulation with other potential materials for wastewater treatment. This review discusses the progress and achievements in the antimicrobial applications of NPs, factors contributing to their actions, mechanisms underlying their efficiency, and risks of their applications, including the antimicrobial action of metal nanoclusters (NCs).The review concludes with a discussion of the restrictions in present studies and future prospects of nanotechnology-based NPs development.

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“…Presently, ZnO NPs have been shown to successfully degrade several phenolic compounds, persistent organic pollutants, and dyes like phenylhydrazine, ortho‐nitrophenol, dimethoate, methyl orange, and acridine orange to name a few [14]. ZnO NPs are active against an array of microorganisms and exhibit good inhibitions following several toxicity mechanisms [15, 16]. They have been tested in combination with antibiotics, such as ceftazidime and ciprofloxacin.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant activity and antifungal fractional inhibitory concentration indices of zinc oxide nanoparticles in combination with carbendazim, mancozeb, and thiram

Jamdagni

Rana

Khatri

2019

Micro & Nano Letters

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The current study reports antioxidant and antifungal activity of green and chemically synthesised zinc oxide nanoparticles in combination with agricultural fungicides carbendazim, mancozeb, and thiram. Nanoparticles were synthesised using previously standardised procedure and characterised, which confirmed particle size of <100 nm. These nanoparticles were then analysed for their antifungal and antioxidant activity. For fractional inhibitory concentration analysis, nanoparticles were combined with fungicides and tested against five fungal phytopathogens, namely Alternaria alternata, Aspergillus niger, Botrytis cinerea, Fusarium oxysporum, and Penicillium expansum. Nanoparticles positively influenced the antifungal potential of all test fungicides and excellent synergism was observed against all tested fungi. Further, the antioxidant activity of the stated nanosuspension was accessed by conducting free radical scavenging assay using 1,1 diphenyl-2-picryl hydrazyl. L-ascorbic acid was used as a standard reference. Radical scavenging improved with increasing concentration of nanoparticles and percent scavenging as high as 87% was observed at 125 µg/mL. Thus, this work reports the synthesis of stable zinc oxide nanosuspension with good antifungal potential and efficient antioxidant activity.

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Metallic Nanoparticles: Potential Antimicrobial and Therapeutic Agents

Cited by 13 publications

References 112 publications

Comparative study of antifungal effect of green and chemically synthesised silver nanoparticles in combination with carbendazim, mancozeb, and thiram

Comparative study of antifungal effect of green and chemically synthesised silver nanoparticles in combination with carbendazim, mancozeb, and thiram

Current approaches for the exploration of antimicrobial activities of nanoparticles

Antioxidant activity and antifungal fractional inhibitory concentration indices of zinc oxide nanoparticles in combination with carbendazim, mancozeb, and thiram

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