Metallic copper as an intrauterine contraceptive adjunct to the “T” device

Zipper, J; Tatum, Howard J.; Pastene, Laura; Medel, M; Rivera, M

doi:10.1016/0002-9378(69)90302-0

Cited by 227 publications

(44 citation statements)

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“…The first modern IUCD was introduced by Lippes in 1961. After that, Tatum and Zipper developed the first medicated devices such as Copper 7 and Copper T. Through these devices the copper is dissoluted in the uterus.The antifertility effect of copper is the result of the dissolution of copper into uterine secretions (1).…”

Section: Introductionmentioning

confidence: 99%

The Association between Copper Containing IUCD and Bacterial Vaginosis

Demirezen¹,

Küçük²,

Beksaç³

2006

Cent Eur J Public Health

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Section: Introductionmentioning

confidence: 99%

The Association between Copper Containing IUCD and Bacterial Vaginosis

Demirezen¹,

Küçük²,

Beksaç³

2006

Cent Eur J Public Health

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“…Zipper et al [1][2][3] showed that copper (and certain other metals such as zinc) attached to an intrauterine carrier can markedly enhance its contraceptive efficacy in both experimental animals and women. The clinical performance of the latest models of copper I.U.D.s such as the Gravigard is very encouraging.…”

Section: Intrauterine Chemical Releasementioning

confidence: 99%

Intrauterine chemical release.

1974

BMJ

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“…The contraceptive effect of the Cu-IUD is mainly dependent on the copper ions released by the corrosion of copper; [35][36][37][38][39] the larger the release rate of cupric ions, the better the contraceptive effect. According to the literature, there is an extremely high corrosive rate during the first few months, known as a cupric ion "burst release" after Cu-IUD insertion.…”

mentioning

confidence: 99%

Alterations in the endometrium of rats, rabbits, and Macaca mulatta that received an implantation of copper/low-density polyethylene nanocomposite

Hu¹,

Wang²,

Rao³

et al. 2014

IJN

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A copper/low-density polyethylene nanocomposite (nano-Cu/LDPE), a potential intrauterine device component material, has been developed from our research. A logical extension of our previous work, this study was conducted to investigate the expression of plasminogen activator inhibitor 1 (PAI-1), substance P (SP), and substance P receptor (SP-R) in the endometrium of Sprague Dawley rats, New Zealand White rabbits, and Macaca mulatta implanted with nano-Cu/LDPE composite. The influence of the nano-Cu/LDPE composite on the morphology of the endometrium was also investigated. Animals were randomly divided into five groups: the sham-operated control group (SO group), bulk copper group (Cu group), LDPE group, and nano-Cu/LDPE groups I and II. An expression of PAI-1, SP, and SP-R in the endometrial tissues was examined by immunohistochemistry at day 30, 60, 90, and 180 postimplantation. The significant difference for PAI-1, SP, and SP-R between the nano-Cu/LDPE groups and the SO group ( P <0.05) was identified when the observation period was terminated, and the changes of nano-Cu/LDPE on these parameters were less remarkable than those of the Cu group ( P <0.05). The damage to the endometrial morphology caused by the nano-Cu/LDPE composite was much less than that caused by bulk copper. The nano-Cu/LDPE composite might be a potential substitute for conventional materials for intrauterine devices in the future because of its decreased adverse effects on the endometrial microenvironment.

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Metallic copper as an intrauterine contraceptive adjunct to the “T” device

Cited by 227 publications

References 0 publications

The Association between Copper Containing IUCD and Bacterial Vaginosis

The Association between Copper Containing IUCD and Bacterial Vaginosis

Intrauterine chemical release.

Alterations in the endometrium of rats, rabbits, and Macaca mulatta that received an implantation of copper/low-density polyethylene nanocomposite

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