Metallic bismuth nanoparticles: Towards a robust, productive and ultrasound assisted synthesis from batch to flow-continuous chemistry

Gomez, Catherine; Hallot, Gauthier; Pastor, Alexandra; Laurent, Sophie; Brun, Émilie; Sicard-Roselli, Cécile; Port, Marc

doi:10.1016/j.ultsonch.2019.04.012

Cited by 23 publications

(18 citation statements)

References 31 publications

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“…Most of the current protocols for synthesizing biologically suitable BiNPs cannot be replicated in non-specialized laboratories. Some methods require specialized equipment, such as gamma irradiators [ 24 ], laser ablation [ 25 ]; or controlled conditions, such as inert atmosphere [ 26 ], vacuum [ 27 ], or high temperatures [ 28 , 29 ]. Also, some protocols require a long-time synthesis [ 24 ], or several intermediate steps [ 30 ].…”

Section: Introductionmentioning

confidence: 99%

Bismuth nanoparticles obtained by a facile synthesis method exhibit antimicrobial activity against Staphylococcus aureus and Candida albicans

2020

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Background Bismuth compounds are known for their activity against multiple microorganisms; yet, the antibiotic properties of bismuth nanoparticles (BiNPs) remain poorly explored. The objective of this work is to further the research of BiNPs for nanomedicine-related applications. Stable Polyvinylpyrrolidone (PVP)-coated BiNPs were produced by a chemical reduction process, in less than 30 min. Results We produced stable, small, spheroid PVP-coated BiNPs with a crystalline organization. The PVP-BiNPs showed potent antibacterial activity against the pathogenic bacterium Staphylococcus aureus and antifungal activity against the opportunistic pathogenic yeast Candida albicans, both under planktonic and biofilm growing conditions. Conclusions Our results indicate that BiNPs represent promising antimicrobial nanomaterials, and this facile synthetic method may allow for further investigation of their activity against a variety of pathogenic microorganisms.

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Section: Introductionmentioning

confidence: 99%

Bismuth nanoparticles obtained by a facile synthesis method exhibit antimicrobial activity against Staphylococcus aureus and Candida albicans

2020

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“…Recently, Wang's group revealed a straightforward technique for producing BiNPs using a well-developed ball-milling process, which is a promising way for synthesizing BiNPs [18]. In addition, Gomez and co-workers synthesized BiNPs by flow chemistry under sonication [19]. In furtherance of this effort, owing to the improved properties of QTMC, especially its hydrophilicity and high metal ion interaction, it is hypothesized that this highly charged biopolymer can better serve as a stabilizing agent for BiNPs in an aqueous media.…”

Section: Introductionmentioning

confidence: 99%

Quaternary Trimethyl Chitosan Chloride Capped Bismuth Nanoparticles with Positive Surface Charges: Catalytic and Antibacterial Activities

et al. 2021

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Quaternary trimethyl chitosan-stabilized bismuth nanoparticles (QTMC-BiNPs) with positive surface charges were uniquely synthesized and fully characterized. In the synthesis, Quaternary Trimethyl Chitosan (QTMC), a water-soluble derivative of chitosan (CTS) was prepared using two-step reductive methylation. The new biopolymeric functionalized ligand was further used as capping agent for the synthesis of QTMC-BiNPs which was applied as antibacterial and catalytic agents. The reaction was carried out at room temperature without the use of energy consuming or high-cost instruments. The QTMC and nanocomposites were characterized by proton nuclear magnetic resonance ( 1 H NMR), attenuated total reflection Fourier-transform infrared, UV-visible, X-ray diffraction, X-ray photoelectron spectroscopy and energy dispersive X-ray spectroscopic techniques. The topology and morphology of the composites were examined with scanning electron microscopy and high-resolution transmission electron microscopy. Thermogravimetric and differential thermal gravimetric analysis were also conducted. The degree of quaternization and degree of dimethylation values of 63.33 and 11.75%, respectively obtained for QTMC confirmed that the main product is a quaternary derivative. The average particle size of QTMC-BiNPs was evaluated to be between 30 and 45 nm. The QTMC-BiNPs revealed clear and uniform lattice fringes with an estimated interplanar d-spacing of 0.32 nm confirming the formation of highly crystalline nanocomposites. A further insight into the antibacterial activities of this nanomaterial were carefully examined on Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) using resazurin based microdilution method for Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC). The obtained results revealed that both bacteria pathogens were effectively inhibited/killed by the QTMC-BiNPs at very low concentrations. The MIC of 15.63 and 125 lg/mL were recorded against E. coli and S. aureus, respectively while the MBC of 31.25 and 500.00 lg/mL were estimated against E. coli and S. aureus, respectively. An extensive evaluation of the catalytic capability of the nanocomposites towards the reduction of 4-nitrophenol to 4-aminophenol was also carried out with highly promising result.Keywords Chitosan Á Quaternary trimethyl chitosan Á Bismuth nanoparticles Á Antibacterial activity Á Catalytic activity

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“…The second NP studied in this work are metallic bismuth NP which possess the same advantages as silica NP in terms of low cost and biocompatibility and could have interesting applications in the medical field as a radiosensitizer in the context of radiotherapy [29][30][31][32], or as contrast agents in X-ray imaging thanks to the high atomic number of bismuth [33][34][35][36]. A few studies are nevertheless available on those NP [37] and a first challenge is to be able to synthesize stable aqueous suspensions by coating the NP with organic molecules. Two different ligands were used in that aim: the citrate ligand, which could interact with the surface thanks to its carboxylate functions, and the lipoic acid ligand modified with PEG, bearing thiol groups to interact with the NP surface.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Organic Molecules Grafted to Silica or Bismuth Nanoparticles by NMR

et al. 2021

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NMR is a powerful characterization tool and we propose to study the surface of silica or bismuth nanoparticles dedicated to medical applications in order to evidence the covalent grafting of organic molecules on their surface. For that aim, DOSY experiments are particularly useful and allow for the discrimination of molecules interacting strongly with the nanoparticle surface from molecules simply weakly adsorbed at the surface. We were able to characterize thoroughly the surface of different silica and bismuth nanoparticles.

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Metallic bismuth nanoparticles: Towards a robust, productive and ultrasound assisted synthesis from batch to flow-continuous chemistry

Cited by 23 publications

References 31 publications

Bismuth nanoparticles obtained by a facile synthesis method exhibit antimicrobial activity against Staphylococcus aureus and Candida albicans

Bismuth nanoparticles obtained by a facile synthesis method exhibit antimicrobial activity against Staphylococcus aureus and Candida albicans

Quaternary Trimethyl Chitosan Chloride Capped Bismuth Nanoparticles with Positive Surface Charges: Catalytic and Antibacterial Activities

Characterization of Organic Molecules Grafted to Silica or Bismuth Nanoparticles by NMR

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