Metallic biomaterials

Wilson, J.

doi:10.1016/b978-0-08-102205-4.00001-5

Cited by 37 publications

(26 citation statements)

References 131 publications

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“…However, these materials have no biological interactions with tissues. Coating/alloying is an interesting approach with a view to establishing and enhancing biological properties at the implant-tissue interface [80].…”

Section: Coating/alloying Of Metallic Biomaterialsmentioning

confidence: 99%

Biological properties of copper-doped biomaterials for orthopedic applications: A review of antibacterial, angiogenic and osteogenic aspects

et al. 2020

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Copper is an essential trace element required for human life, and is involved in several physiological mechanisms. Today researchers have found and confirmed that Cu has biological properties which are particularly useful for orthopedic biomaterials applications such as implant coatings or biodegradable filler bone substitutes. Indeed, Cu exhibits antibacterial functions, provides angiogenic ability and favors osteogenesis; these represent major key points for ideal biomaterial integration and the healing process that follows. The antibacterial performances of copper-doped biomaterials present an interesting alternative to the massive use of prophylactic antibiotics and help to limit the development of antibiotic resistance. By stimulating blood vessel growth and new bone formation, copper contributes to the improved bio-integration of biomaterials. This review describes the bio-functional advantages offered by Cu and focuses on the antibacterial, angiogenic and osteogenic properties of Cu-doped biomaterials with potential for orthopedic applications.

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Section: Coating/alloying Of Metallic Biomaterialsmentioning

confidence: 99%

Biological properties of copper-doped biomaterials for orthopedic applications: A review of antibacterial, angiogenic and osteogenic aspects

et al. 2020

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“…Concerning the potential implant, only a few material classes can fulfill the challenging requirements. However, several metallic materials have been used since the early 1900s as scaffolds and for load-bearing implants [2]. Typical biomedical applications are wires, screws for fracture fixation plates, and joint prostheses for hips, knees, or shoulders [2].…”

Section: Introductionmentioning

confidence: 99%

“…However, several metallic materials have been used since the early 1900s as scaffolds and for load-bearing implants [2]. Typical biomedical applications are wires, screws for fracture fixation plates, and joint prostheses for hips, knees, or shoulders [2]. Further on, metallic implants were used in cardiovascular surgery and dental medicine.…”

Section: Introductionmentioning

confidence: 99%

“…Further on, metallic implants were used in cardiovascular surgery and dental medicine. The most commonly favored metals in the medical sector are stainless steel, titanium and its alloys, and cobalt-based as well as tantalum-based alloys [2].…”

Section: Introductionmentioning

confidence: 99%

“…Until now, high surface roughness and process-induced defects, such as porosity or near-surface notch-like defects, are limiting factors. Regarding in vivo applications, near-surface defects can facilitate corrosion processes which can end up in early failure of the implant and increased risk of toxicity [2]. Therefore, the material, especially the damage behavior of the used materials, has to be understood in detail.…”

Section: Introductionmentioning

confidence: 99%

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Corrosion and Corrosion Fatigue Properties of Additively Manufactured Magnesium Alloy WE43 in Comparison to Titanium Alloy Ti-6Al-4V in Physiological Environment

et al. 2019

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Laser powder bed fusion (L-PBF) of metals enables the manufacturing of highly complex geometries which opens new application fields in the medical sector, especially with regard to personalized implants. In comparison to conventional manufacturing techniques, L-PBF causes different microstructures, and thus, new challenges arise. The main objective of this work is to investigate the influence of different manufacturing parameters of the L-PBF process on the microstructure, process-induced porosity, as well as corrosion fatigue properties of the magnesium alloy WE43 and as a reference on the titanium alloy Ti-6Al-4V. In particular, the investigated magnesium alloy WE43 showed a strong process parameter dependence in terms of porosity (size and distribution), microstructure, corrosion rates, and corrosion fatigue properties. Cyclic tests with increased test duration caused an especially high decrease in fatigue strength for magnesium alloy WE43. It can be demonstrated that, due to high process-induced surface roughness, which supports locally intensified corrosion, multiple crack initiation sites are present, which is one of the main reasons for the drastic decrease in fatigue strength.

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