Metal streak artifacts in X-ray computed tomography: a simulation study

Man, Bruno De; Nuyts, Johan; Dupont, Patrick; Marchal, Guy; Suetens, Paul

doi:10.1109/23.775600

Cited by 253 publications

(166 citation statements)

References 20 publications

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“…13,18,19 In most of these studies, polymeric, ceramic, collagen scaffolds, or composites were used, in which, the mineralized extracellular matrix (ECM) could be separated from the scaffold for the purpose of volume calculations and no significant material-dependent artifacts were present. However, when imaging the ECM or tissue growth in metallic scaffolds or around implants, additional caution has to be taken during image analysis as metal artifacts 20,21 can significantly influence the accuracy of the quantification of the newly formed ECM or tissue volume. 22,23 Several studies have shown that when using phase-contrast imaging, in most cases only available by synchrotron radiation, the nonmineralized ECM formed in vitro in 3D TE constructs can be visualized.…”

Section: Introductionmentioning

confidence: 99%

Three-Dimensional Characterization of Tissue-Engineered Constructs by Contrast-Enhanced Nanofocus Computed Tomography

Papantoniou

Sonnaert

Geris

et al. 2014

Tissue Engineering Part C: Methods

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To successfully implement tissue-engineered (TE) constructs as part of a clinical therapy, it is necessary to develop quality control tools that will ensure accurate and consistent TE construct release specifications. Hence, advanced methods to monitor TE construct properties need to be further developed. In this study, we showed proof of concept for contrast-enhanced nanofocus computed tomography (CE-nano-CT) as a whole-construct imaging technique with a noninvasive potential that enables three-dimensional (3D) visualization and quantification of in vitro engineered extracellular matrix (ECM) in TE constructs. In particular, we performed a 3D qualitative and quantitative structural and spatial assessment of the in vitro engineered ECM, formed during static and perfusion bioreactor cell culture in 3D TE scaffolds, using two contrast agents, namely, Hexabrix Ò and phosphotungstic acid (PTA). To evaluate the potential of CE-nano-CT, a comparison was made to standardly used techniques such as Live/Dead viability/cytotoxicity, Picrosirius Red staining, and to net dry weight measurements of the TE constructs. When using Hexabrix as the contrast agent, the ECM volume fitted linearly with the net dry ECM weight independent from the flow rate used, thus suggesting that it stains most of the ECM. When using PTA as the contrast agent, comparing to net weight measurements showed that PTA only stains a part of the ECM. This was attributed to the binding specificity of this contrast agent. In addition, the PTA-stained CE-nano-CT data showed pronounced distinction between flow conditions when compared to Hexabrix, indicating culture-specific structural ECM differences. This novel type of information can contribute to optimize bioreactor culture conditions and potentially critical quality characteristics of TE constructs such as ECM quantity and homogeneity, facilitating the gradual transformation of TE constructs in well-characterized TE products.

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Section: Introductionmentioning

confidence: 99%

Three-Dimensional Characterization of Tissue-Engineered Constructs by Contrast-Enhanced Nanofocus Computed Tomography

Papantoniou

Sonnaert

Geris

et al. 2014

Tissue Engineering Part C: Methods

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“…13 Bunlara ek olarak, gürültü(noise) ve skaterlerin (ışın saçılmalarının) de artefaktlara neden olduğu bilinmektedir. 14 …”

Section: Koni̇k Işinli Bi̇lgi̇sayarli Tomografi̇de Artefakt çEşi̇tleri̇ Ve unclassified

Konik Işinli Bilgisayarli Tomografide Artefakt Çeşitleri Ve Nedenleri

Kalabalık¹,

Ertaş²

2015

Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi

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“…Common examples of these are ring artefacts, caused by the failure of one or more pixels in a pixellated detector or by the nonlinearity of different pixels (Sijbers and Postnov, 2004), streak artefacts, usually caused by highly-attenuating inclusions (De Man et al, 1998), and artefacts caused by instability or movement of the sample. Less common artefacts include secondary radiation effects (Boone et al, 2012b), detector lag (Siewerdsen and Jaffray, 1999) and charge sharing effects (Firsching, 2009).…”

Section: Imaging Artefactsmentioning

confidence: 99%

High-resolution X-ray computed tomography in geosciences: A review of the current technology and applications

Cnudde

Boone

2013

Earth-Science Reviews

1,226

700

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Please cite this article as: Cnudde, V., Boone, M.N., "High-resolution X-ray computed tomography in geosciences: a review of the current technology and applications", Earth Science Reviews (2013Reviews ( ), doi: 10.1016Reviews ( /j.earscirev.2013 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.A C C E P T E D M A N U S C R I P T AbstractHigh-resolution X-ray Computed Tomography (HRXCT) or micro-CT (µCT) is a frequently used non-destructive 3D imaging and analysis technique for the investigation of internal structures of a large variety of objects, including geomaterials. Although the possibilities of X-ray micro-CT are becoming better appreciated in earth science research, the demands on this technique are also approaching certain physical limitations. As such, there remains a lot of research to be done in order to solve all the technical problems that occur when higher demands are put on the technique. In this paper, a review of the principle, the advantages and limitations of X-ray CT itself are presented, together with an overview of some current applications of micro-CT in geosciences. One of the main advantages of this technique is the fact that it is a non-destructive characterization technique which allows 4D monitoring of internal structural changes at resolutions down to a few hundred nanometers. Limitations of this technique are the operator dependency for the 3D image analysis from the reconstructed data, the discretations effects and possible imaging artefacts. Driven by the technological and computational progress, the technique is continuously growing as an analysis tool in geosciences and is becoming one of the standard techniques, as is shown by the large and still increasing number of publications in this research area. It is foreseen that this number will continue to rise, and micro-CT will become an indispensable technique in the field of geosciences.

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Metal streak artifacts in X-ray computed tomography: a simulation study

Cited by 253 publications

References 20 publications

Three-Dimensional Characterization of Tissue-Engineered Constructs by Contrast-Enhanced Nanofocus Computed Tomography

Three-Dimensional Characterization of Tissue-Engineered Constructs by Contrast-Enhanced Nanofocus Computed Tomography

Konik Işinli Bilgisayarli Tomografide Artefakt Çeşitleri Ve Nedenleri

High-resolution X-ray computed tomography in geosciences: A review of the current technology and applications

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