Metal Storage Disorders

Kanwar, Pushpjeet; Kowdley, Kris V.

doi:10.1016/j.mcna.2013.09.008

Cited by 19 publications

(3 citation statements)

References 94 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Types I-III are linked to altered or reduced expression of hepcidin [11,25,27], whereas type IV results from reduced iron export [1,28]. Mutations in HFE, HJV, HAMP, TFR2 and SLC40A1 have been linked to the various types of hemochromatosis [11,25,29], each displaying different onsets, severities and prevalences [2,4,9,25,27,[29][30][31][32][33] (Table 1).…”

Section: Genetics and Penetrancementioning

confidence: 99%

“…The subsequent sequestration of iron in organs leads to tissue damage and eventually symptomatic disease [3,4].…”

Section: Introductionmentioning

confidence: 99%

“…It is widely accepted that excess SF ([1,000 lg/l) can cause disease symptoms ranging from lethargy and fatigue, to endocrine dysfunction, to arthritis of the 2nd and 3rd metacarpophalangeal joints [4,11]. However, the effect of mildly elevated SF between 300 and 100 lg/l is less clear; this is currently under investigation.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Recent advances in hemochromatosis: a 2015 update

2015

View full text Add to dashboard Cite

This review focuses on iron metabolism, the genetics of hemochromatosis, current treatment protocols and various screening methods. Even though the most common form of hereditary hemochromatosis, C282Y gene mutations in the HFE gene, has been extensively studied, novel mutations in both HFE and non-HFE genes have been implicated in this disease. These have important implications for the Asia-Pacific region. In overload, deposition of iron in various body tissues leads to toxic damage. Patients commonly present with non-specific symptoms of malaise and lethargy. Biochemical, imaging and genetic testing can be carried out to confirm diagnosis. Venesection forms the mainstay of treatment and at present cascade screening of affected families is recommended over population-level screening.

show abstract

Section: Genetics and Penetrancementioning

confidence: 99%

“…The subsequent sequestration of iron in organs leads to tissue damage and eventually symptomatic disease [3,4].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Recent advances in hemochromatosis: a 2015 update

2015

View full text Add to dashboard Cite

show abstract

Liver Transplantation

Michel¹,

Marcus²

2016

Pathology of Transplantation

View full text Add to dashboard Cite

Biochemical studies on the effect of different water resources in Hail region on liver and kidney functions of rats

Talkhan

Elwahab

Shalapy

2016

Environ Monit Assess

View full text Add to dashboard Cite

Low concentration of a heavy metal is toxic and can be classified as one of the pollution sources. Industrial and human waste can pollute water with heavy metals and soils breaking down under the effect of acidic rain, which release heavy metals into river, streams, lakes, and ground water. Bioaccumulation of heavy metals in vital organs of the human body damages these organs, including the liver and kidney, which are the main organs for metabolism, detoxification, and excretion. The present study aims to investigate into concentrations of such heavy metals (Fe, Cu, Zn, and Pb) in both ground and tap water samples collected from different areas in Hail region, KSA. Then, this study moves forward to examine the effects of such concentrations on the biochemistry of serum in rats. In this regard, the results demonstrate the presence of significant differences (p < 0.05) in the liver function parameters, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total proteins, albumin, and globulin between all the studied groups that were exposed to heavy-metals-polluted water, when compared with the control group. In addition, there were significant differences (p < 0.05) in the kidney function parameters, uric acid, urea, and creatinine, when compared with the control group. Thence, and as this study indicates, heavy-metals-polluted water can cause disturbance in the liver and kidney function parameters, which highlights health risks of the water polluted with heavy metals. In this sense, the concerned authorities should regularly carry out survey and should monitor underground water, and people have to be aware of such risks.

show abstract

Metal Storage Disorders

Cited by 19 publications

References 94 publications

Recent advances in hemochromatosis: a 2015 update

Recent advances in hemochromatosis: a 2015 update

Liver Transplantation

Biochemical studies on the effect of different water resources in Hail region on liver and kidney functions of rats

Contact Info

Product

Resources

About