Metal-sediment interaction during resuspension

Brassard, P.; Kramer, James R.; McAndrew, James; Mueller, Edna L.

doi:10.1007/bf00005735

Cited by 24 publications

(11 citation statements)

References 12 publications

(15 reference statements)

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“…For instance, shear stress is induced through water oscillation in flumes or chambers (Young 1977;Mehta et al 1982;Lick 1982;Tsai and Lick 1986;Brassard et al 1994). These experiments can also provide insight into the relevant adsorption mechanisms on recycling particles (Brassard et al 1994). The basic problem, however, is the extrapolation of the experimental results to the in-situ conditions in lakes.…”

Section: Laboratory Experimentsmentioning

confidence: 99%

“…The ecological importance of sediment resuspension is found in the intense cycling of particulate material and associated nutrients and contaminants (Lick and Lick 1988;Brassard et al 1994). This recycling must be included in lake models, where settling flux, burial (bottom sediment increment) and internal load (sediment-water exchange processes) are important parameters.…”

Section: The Ecological Importance Of Resuspensionmentioning

confidence: 99%

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Mechanisms, measurement and importance of sediment resuspension in lakes

Bloesch¹

1995

Mar. Freshwater Res.

211

108

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The process of sediment resuspension in lakes influences lake metabolism by causing turbidity and cycling of particulate material. Wind, currents and morphometry of the lake basin are the most important causes of resuspension. So far, episodic resuspension events have been studied, rather than the impact on whole lakes. The bottom shear stress and the cohesion of sediments are the key mechanisms for sediment resuspension. Two zones of resuspension can be distinguished: the littoral zone, where wave action is significant; and the profundal zone, where seiche-induced currents are the most important factor governing resuspension. Repetitive sediment resuspension and redeposition over large areas are common in shallow lakes. Nearshore sediment resuspension, subsequent focusing and redeposition in the profundal zone are the main processes in large, deep lakes. The various methods of measuring sediment resuspension are reviewed, with special emphasis on the sediment trap method and the use of radionuclides.

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Section: Laboratory Experimentsmentioning

confidence: 99%

Section: The Ecological Importance Of Resuspensionmentioning

confidence: 99%

Mechanisms, measurement and importance of sediment resuspension in lakes

Bloesch¹

1995

Mar. Freshwater Res.

211

108

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“…For example, the shear stress is induced through water oscillation in flumes or chambers (Mehta et al, 1982;Lick, 1982;Tsai & Lick, 1986;Brassard et al, 1994). However, the basic problem is to relate results obtained from lab tests to the extremely variable in-situ conditions.…”

Section: Review Of Methods and Results And Discussionmentioning

confidence: 99%

A review of methods used to measure sediment resuspension

Bloesch

1994

Hydrobiologia

100

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Resuspension of bottom sediments is an important lake-internal process with regard to particle cycling and sedimentation. Current methods to measure sediment resuspension are reviewed, such as optical and acoustical instruments, instantaneous multiple point water samplers, sediment traps, sediment cores and grabs, radiotracers such as Pb210, CS'~~ and Be7, mass balance calculations, various modelling approaches, statistical methods (correlation analysis), and laboratory experiments.For the quantification of resuspension, the combined use of sediment traps, sediment cores, near bottom current meters, and turbidity meters to measure suspended and settling particulate matter in the hypolimnion of lakes is recommended; in addition, wind stress, seiches, slumping and sliding, and river-me input may be monitored to elucidate the mechanisms behind the process.

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“…Interestingly, although HER2 has no identified ligand, it is a preferred partner for the formation of heterodimer (Tzahar et al, 1997). Meanwhile, since HER3 lacks intrinsic kinase activity (Guy, Platko, Cantley, Cerione, & Carraway, 1994), the activation of HER3 relies on ligand (neuregulin-1/NRG1 and neuregulin-2/NRG2) binding and/or heterodimerization with other HER receptors (Carraway et al, 1994(Carraway et al, , 1997. Among all the homodimer and heterodimer pairs necessary for EGFR/HER activity, the HER2/HER3 heterodimer is considered to be the most potent one for the activation of downstream signalling (Pinkas-Kramarski et al, 1996;Tzahar et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

Corosolic acid inhibits colorectal cancer cells growth as a novel HER2/HER3 heterodimerization inhibitor

Zhang

Chen

et al. 2021

British J Pharmacology

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Background and Purpose Colorectal cancer is the third most common cancer worldwide. HER2 and HER3 are two members of human epidermal receptor family of tyrosine kinase receptors (RTKs) and associated with poor survival in colorectal cancer. They have been observed as important therapeutic targets in various types of cancer. Corosolic acid, a natural pentacyclic triterpene, has been demonstrated to have a significant anti‐cancer activity. However, the target of corosolic acid has not yet been explored. This study aimed to reveal the direct targets of corosolic acid underlying its anti‐cancer activities. Experimental Approach The targets of corosolic acid were revealed by the phospho‐RTK array, bio‐layer interferometry, co‐immunoprecipitation, and proximity ligation assay. The inhibitory action of corosolic acid on HER2/HER3 heterodimerization and related downstream signalling were investigated in HCT116 and SW480 cells. In addition, the chemo‐preventive effects of corosolic acid were validated in both HCT116 xenograft model and AOM/DSS model. Key Results Our results demonstrated that corosolic acid could prevent NRG1‐induced HER2/HER3 heterodimerization and suppress the phosphorylation of both HER2 and HER3. Furthermore, HER2 and HER3 could regulate the downstream signalling pathways of RalA/RalBP1/CDK1 and PI3K/Akt/PKA, respectively, resulting in the changes in phosphorylation of Drp1 and mitochondrial dynamics. corosolic acid exhibited anti‐cancer activity in both HCT116 xenograft model and AOM/DSS model. Conclusions and Implications Collectively, our results demonstrated corosolic acid directly targeted HER2 and HER3 heterodimerization and inhibited mitochondrial fission via regulating RalA/RalBP1/CDK1 and PI3K/Akt/PKA pathways, revealing a novel mechanism underlying the beneficial effects of corosolic acid on colorectal cancer.

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Metal-sediment interaction during resuspension

Cited by 24 publications

References 12 publications

Mechanisms, measurement and importance of sediment resuspension in lakes

Mechanisms, measurement and importance of sediment resuspension in lakes

A review of methods used to measure sediment resuspension

Corosolic acid inhibits colorectal cancer cells growth as a novel HER2/HER3 heterodimerization inhibitor

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