Metal-promoted synthesis of amidines containing the model nucleobases 1-methylcytosine and 9-methyladenine

Abstract

The amidine complexes cis-[L 2 PtNH C(R){1-MeCy(-2H 2+ . In fact, addition of "proton sponge" leads to the immediate deprotonation of the amidine ligand with formation of the starting complexes 1b and 2b.)

From cyclic amines and acetonitrile to amidine zinc(ii) complexes

“…The parent amidine, formed in the presence of platinum(II), was a condensation product of the benzonitrile reaction with 1-methylcytosine. 76 For comparison, in our compounds with amidinium cations, the difference between the C-N bonds was not larger than 0.014Å. 13) contain [Zn(quin) 3 ] À ions with zinc(II) in a six-numbered coordination environment.…”

Reactions of platinum(iv)-bound nitriles with isomeric nitroanilines: addition vs. substitution

“…2c,d) shows that the largest fraction of research is devoted to the creation of a C-N bond by the addition sp 3 -and sp 2 -(H)N-nucleophiles, as well as by coupling of some nitrogen heterocycles 5 with ligated RCN species. Recent examples include nucleophilic addition of di-and triamines to (nitrile)Pt IV species, 6 coupling of primary amines, 4b,7 ferrocenyl-functionalized amine, 8 and nucleobases 9 with Pt II -bound nitriles.…”

Synthesis of Macrocyclic Nickel(II) Complexes Bearing N,N‐Disubstituted Amidine Pendant Arms: Metal‐induced CN Bond Cleavage of the Amidine Group Involving a 14‐Membered Tetraaza Macrocycle

“…Amidines (RC(NH)NR′R″) are important intermediates in the synthesis of a wide range of molecules, including biologically active compounds . Various organic amidines have been prepared by the reaction of nitriles with amides, ammonia, or amines.…”

“…Various organic amidines have been prepared by the reaction of nitriles with amides, ammonia, or amines. Some organic nitriles (RCN) coordinated to transition‐metal ions can react with amines (R′R″NH) under relatively mild conditions to produce RC(NH)NR′R″ …”