Metal piracy by Neisseria gonorrhoeae to overcome human nutritional immunity

Liyayi, Ian K; Forehand, Amy L; Ray, Jocelyn C; Criss, Alison K.

doi:10.1371/journal.ppat.1011091

Cited by 2 publications

(1 citation statement)

References 32 publications

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“…Indeed, N. gonorrhoeae must seek for vital nutrients like iron, zinc, copper and manganese that are limited by the human host as a defense against bacterial pathogens in a process termed nutritional immunity and metal intoxication. The N. gonorrhoeae has unique ways to subvert and evade from the harsh condition of metal intoxication and nutritional immunity, particularly by producing transporters that bind and extract metals from human metal-sequestering proteins" [82,83].…”

Section: Competitionmentioning

confidence: 99%

Gonorrhoeae must Compete with the Naturally Inhabitant of Microbial Community Right at the Outer Mucosal Surface to Authorize Infection

Sunarti

2023

IJPR

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Aim: to describe the competition between Neisseria gonorrhoeae with the naturally inhabitant of microbial community right at the outer mucosal surface to authorize infection. Discussion: Gonorrhea is a sexually transmitted infection (STI) caused by the bacterium N. gonorrhea. Official report mention that by the year 2020, there were an estimated 82.4 million new infections among adults globally and poses a risk of onward transmission to sex partners. It surely could affect both men and women; for male, the symptoms are more obvious, but for women it occurs more often without prominent clinical symptoms and usually lead to long-term health problems including pelvic inflammatory disease and infertility. The female reproductive tract with its abundant variety of epithelial cells act as its primary niche where initially it was inhabited by normal microbiota, characterized by a high abundance of Lactobacilli, and uniquely linked to the host’s mucosal immunity and plays a critical role in the regulation of genital inflammation. Unfortunately, the dynamics regarding number and composition of vaginal microbiota has been shown to fluctuate over several internal and external factors, especially due to STI like gonorrhea. Its proposed evolution from an ancestral commensal bacterium, N. gonorrhoeae has retained features that are commonly found among commensal inhabitants, but it has also developed unique features that are crucial to its pathogenesis. The scope of its pathogenesis field elucidate competition, colonization and growth properties as main virulence determinants. Conclusion: Competition between N. gonorrhoeae and the already exist natural microbiota of the vagina occur initially at the mucosal surface. This gonococcus has several intrinsic factors that can facilitate its competitiveness including adherence, even though not all available adhesion mechanisms are actually used by this organism during the course of infection/colonization of any specific site.

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Section: Competitionmentioning

confidence: 99%

Gonorrhoeae must Compete with the Naturally Inhabitant of Microbial Community Right at the Outer Mucosal Surface to Authorize Infection

Sunarti

2023

IJPR

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Dinner date: Neisseria gonorrhoeae central carbon metabolism and pathogenesis

Potter

Criss

2023

Emerging Topics in Life Sciences

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Neisseria gonorrhoeae, the causative agent of the sexually transmitted infection gonorrhea, is a human-adapted pathogen that does not productively infect other organisms. The ongoing relationship between N. gonorrhoeae and the human host is facilitated by the exchange of nutrient resources that allow for N. gonorrhoeae growth in the human genital tract. What N. gonorrhoeae ‘eats' and the pathways used to consume these nutrients have been a topic of investigation over the last 50 years. More recent investigations are uncovering the impact of N. gonorrhoeae metabolism on infection and inflammatory responses, the environmental influences driving N. gonorrhoeae metabolism, and the metabolic adaptations enabling antimicrobial resistance. This mini-review is an introduction to the field of N. gonorrhoeae central carbon metabolism in the context of pathogenesis. It summarizes the foundational work used to characterize N. gonorrhoeae central metabolic pathways and the effects of these pathways on disease outcomes, and highlights some of the most recent advances and themes under current investigation. This review ends with a brief description of the current outlook and technologies under development to increase understanding of how the pathogenic potential of N. gonorrhoeae is enabled by metabolic adaptation.

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Metal piracy by Neisseria gonorrhoeae to overcome human nutritional immunity

Cited by 2 publications

References 32 publications

Gonorrhoeae must Compete with the Naturally Inhabitant of Microbial Community Right at the Outer Mucosal Surface to Authorize Infection

Gonorrhoeae must Compete with the Naturally Inhabitant of Microbial Community Right at the Outer Mucosal Surface to Authorize Infection

Dinner date: Neisseria gonorrhoeae central carbon metabolism and pathogenesis

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