Metal-pilfering pathogens

Deane, Caitlin

doi:10.1038/nchembio.2139

Cited by 1 publication

(3 citation statements)

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“…For protein representation, the following Protein Data Bank entries have been used: transferrin (1d3k), lactoferrin (1b0l), ferritin (1fha), hemopexin (1qhu), Hp 1-1 (extracted from 4wjg), IsdB N1N2 (extracted from 5vmm), IsdH N2N3 (extracted from 6tb2), FepB (3o72, illustration of the homolog Escherichia coli EfeB), and Hb/heme/iron (1a3n). Staphyloferrin A and B, and staphylopine have been modelled on the basis of Endicott et al [46] and Deane [47] works, respectively. Proteins are divided into three groups based on the source of iron they exploit.…”

Section: Figurementioning

confidence: 99%

“…It has been demonstrated, both in vitro and in vivo, that an impaired efflux of StP leads to the metallophore accumulation in the cytoplasm, with detrimental effects on S. aureus growth [105]. [106] on the basis of iron-bound models [46,47]. The chemical structures were drawn with Chemicalize.…”

Section: Other Endogenous Iron-chelatorsmentioning

confidence: 99%

“…Figure 2.Structures of the three siderophores of S. aureus, adapted from Neumann et al[106] on the basis of iron-bound models[46,47]. The chemical structures were drawn with Chemicalize.…”

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confidence: 99%

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Iron Metabolism at the Interface between Host and Pathogen: From Nutritional Immunity to Antibacterial Development

Marchetti

Bei

Bettati

et al. 2020

IJMS

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Nutritional immunity is a form of innate immunity widespread in both vertebrates and invertebrates. The term refers to a rich repertoire of mechanisms set up by the host to inhibit bacterial proliferation by sequestering trace minerals (mainly iron, but also zinc and manganese). This strategy, selected by evolution, represents an effective front-line defense against pathogens and has thus inspired the exploitation of iron restriction in the development of innovative antimicrobials or enhancers of antimicrobial therapy. This review focuses on the mechanisms of nutritional immunity, the strategies adopted by opportunistic human pathogen Staphylococcus aureus to circumvent it, and the impact of deletion mutants on the fitness, infectivity, and persistence inside the host. This information finally converges in an overview of the current development of inhibitors targeting the different stages of iron uptake, an as-yet unexploited target in the field of antistaphylococcal drug discovery.

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Section: Figurementioning

confidence: 99%