Metal Phthalocyanine and Crown Ether–Based Membranes for the Potentiometric Determination of Phenylalanine Methyl Ester Using an Ion-Selective Electrode

Blikova, Yu. N.; Otkidach, K. N.; Shvedene, N. V.; Pletnev, I. V.; Sheina, N.M.; Gorbunova, Yulia G.

doi:10.1023/b:janc.0000030884.77442.12

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…Given the fact that, pregabalin as an amino acid derivative with amino, carboxylic groups and hydrophobic moiety, must to be taken into consideration to be recognized, attention will be turned toward a multitopic receptor approach [33,34].…”

Section: Performance Characteristics Of Pregabalin Selective Sensorsmentioning

confidence: 99%

Potentiometric sensing platform for selective determination of Pregabalin in pharmaceutical formulations

El-Naby¹

2019

Open J Anal Bioanal Chem

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Pregabalin is a structural analogue of, but functionally unrelated to, the naturally occurring neurotransmitter -aminobutyric acid (GABA) with potent analgesic, anticonvulsant and anxiolytic activity.The abuse potential of pregabalin is a well-documented with high risk of addiction that may be fatal with overdoses particularly, among opiate addicts and polydrug use dependency syndrome, consequently, it is very pertinent to determine pregabalin in a sensitive and selective manner. Herein, for the fi rst time the use of β-cyclodextrin:phosphomolybdic acid organic-inorganic hybrid material as a neutral ionophore in polymeric membrane based selective sensors for the determination of pregabalin in its pharmaceutical formulations has been reported. The fabricated sensors yielded an excellent performance, with a linear range from 1.0×10 6 to 1.0×10 1 M pregabalin, a response slope closer to the ideal Nernstian value; 59.6 mV per decade as well as a detection limit was 6.0×10 7 M and very short response time of about 5 s for high concentrations. The most interesting feature of the sensors is their remarkably selective recognition for pregabalin compared with opioids and this is an important issue that is suited to practical applications. The sensors were effectively used for the determination of pregabalin in pharmaceutical formulations with a recovery of 100.97%±0.17. On comparison with β-cyclodextrin, the proposed sensors exhibited the best performance characteristics.

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Section: Performance Characteristics Of Pregabalin Selective Sensorsmentioning

confidence: 99%

Potentiometric sensing platform for selective determination of Pregabalin in pharmaceutical formulations

El-Naby¹

2019

Open J Anal Bioanal Chem

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Calix protected gold nanobeacon as turn-off fluorescent sensor for phenylalanine

Mishra

Darjee

Bhatt

et al. 2015

J Incl Phenom Macrocycl Chem

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Metal Phthalocyanine and Crown Ether–Based Membranes for the Potentiometric Determination of Phenylalanine Methyl Ester Using an Ion-Selective Electrode

Cited by 2 publications

References 8 publications

Potentiometric sensing platform for selective determination of Pregabalin in pharmaceutical formulations

Potentiometric sensing platform for selective determination of Pregabalin in pharmaceutical formulations

Calix protected gold nanobeacon as turn-off fluorescent sensor for phenylalanine

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