Metal particles in mucus and hypertrophic tissue of the inferior nasal turbinates from the human upper respiratory tract

Čabanová, Kristína; Motyka, Oldřich; Čábalová, Lenka; Hrabovská, Kamila; Bielniková, Hana; Kuzníková, Ľubomíra; Jana, Debarshi; Zeleník, Karol; Komínek, Pavel; Kukutschová, Jana

doi:10.1007/s11356-020-09156-7

Cited by 5 publications

(8 citation statements)

References 46 publications

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“…The results of this study are therefore in accordance with the general direction of the field of nanotoxicology with numerous studies focusing on possible health implications of manufactured carbon- and titanium-based nanomaterials (carbon nanotubes, printer ink, pigments, cosmetics compounds etc.) [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…The striking difference between the presence of solid particles in the CRS and the control group is possibly the most remarkable result obtained in this study. Epithelial barrier dysfunction and its increased permeability is one of the pathogenetic mechanisms in chronic mucosal inflammation and has been studied in chronic rhinosinusitis, as well [ 12 , 31 , 32 ]. This could be the possible explanation to our findings—in healthy mucosa, the deposition of solid particles is prevented by functional epithelial barrier mechanisms (mucocilliary transport, intercellular junctions, intact basement membrane, etc.…”

Section: Discussionmentioning

confidence: 99%

“…Smoking status and occupational history indicate increased exposition of smokers and certain workers to airborne particles. In the study, significant association of smoking and high-risk (“manual”) occupation with presence of carbon compounds was found, while these two characteristics are inseparable (all the smokers in the CRS group were “manual” workers) because of clear association of daily smoking and social class [ 12 , 34 ].…”

Section: Discussionmentioning

confidence: 99%

“…They can penetrate tissues both paracellularly and through cells and become bloodborne, redistribute in the organism and accumulate in vital organs, while the possibility of their lysosomal degradation, in contrast to MPs, is limited [ 7 ]. Due to their size being similar to the size of subcellular structures and increased reactivity, they can interfere with the function of organelles, enzymes or antibodies and also exhibit genotoxic properties, by induction of oxidative stress and by direct interaction with DNA [ 10 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

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Solid Anorganic Particles and Chronic Rhinosinusitis: A Histopathology Study

Čábalová

Čabanová

Bielniková

et al. 2022

IJERPH

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Although extensive research has shown the pathological effect of fine and ultrafine airborne particles, clear evidence of association of environmental exposure to them and inflammatory changes in human nasal mucosa is missing. Meanwhile, pathogenesis of chronic rhinosinusitis, despite being a disease with high prevalence in the population, is still unclear. The increasing evidence of the pro-inflammatory properties of these particles raises the question of their possible role in chronic rhinosinusitis. The presented study focused on detection of microsized anorganic particles and clusters of nanosized anorganic particles in the nasal mucosa of patients with chronic rhinosinusitis by Raman microspectroscopy and comparison of their composition to histologic findings. The results were compared to the findings in mucosa obtained from cadavers with no history of chronic rhinosinusitis. Solid particles were found in 90% of tissue samples in the group with chronic rhinosinusitis, showing histologic signs of inflammation in 95%, while in the control group, the particles were found in 20% of samples, with normal histologic findings in all of them. The main detected compounds were graphite, TiO2, amorphous carbon, calcite, ankerite and iron compounds. The results are in accordance with the premise that exogenous airborne particles interact with the nasal mucosa and possibly deposit in it in cases where the epithelial barrier is compromised in chronic rhinosinusitis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Solid Anorganic Particles and Chronic Rhinosinusitis: A Histopathology Study

Čábalová

Čabanová

Bielniková

et al. 2022

IJERPH

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“…Previous studies suggested that some micro-and submicro-sized metal particles trapped by the mucus tissue of the upper respiratory tract can travel through the mechanical barrier of the mucosal tissue and penetrate the tissue, which may initiate various pathological states. A study by Čabanová et al [28] found metal particles such as Ti, Zn, Fe, and Ba from the cytological mucus and hypertrophic tissue samples from a patient diagnosed with chronic hypertrophic rhinosinusitis characterized by scanning electron microscopy and Raman microspectroscopy. Another study by Jiang et al [29] found Ca and Zn elements in the fungal ball specimens by the x-ray fluorescence technique.…”

Section: Discussionmentioning

confidence: 99%

Energy-Dispersive X-ray Spectroscopic Investigation of Failed Dental Implants Associated with Odontogenic Maxillary Sinusitis

Nguyen¹,

Eo²,

Sodnom-Ish³

et al. 2021

Applied Sciences

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The failed dental implant associated with maxillary sinusitis is a multifactorial phenomenon and should be investigated thoroughly. The inflammatory process induced by accumulated biofilm and wear debris may increase mucous secretion and mucous thickening, which finally may lead to severe complications such as maxillary sinusitis. The inflammatory cytokines might compromise the long-term osseointegration of the related implant. In this study, implants retrieved from three patients who experienced implant failure relating to maxillary sinusitis were investigated using scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy. SEM analysis of the implant apical region revealed a less-compact bone structure, indicating the high bone turnover due to an inflammatory process. The ratio of calcium (Ca) and phosphorus (P) was negligible in all specimens. Detection of fluorine (F), sodium (Na), silicon (Si), gold (Au), aluminum (Al), and magnesium (Mg) confirmed the contamination. The selected cases presented different biological aspects that might play the central role in the failed dental implants associated with maxillary sinusitis: the contamination of potentially toxic elements, microorganism infection, and long perforation of implant apex into the sinus. Each of the above phenomena needs to be confirmed with further clinical study with a larger number of failed implants and accompanying tissue samples.

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Label-Free Identification of Carbonaceous Particles Using Nonlinear Optical Microscopy

et al. 2023

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The adverse health effects of ambient carbonaceous particles (CPs) such as carbon black (CB), black carbon (BC), and brown carbon (BrC) are becoming more evident and depend on their composition and emission source. Therefore, identifying and quantifying these particles in biological samples are important to better understand their toxicity. Here, we report the development of a nonlinear optical approach for the identification of CPs such as CB and BrC using imaging conditions compatible with biomedical samples. The unique visible light fingerprint of CB and BrC nanoparticles (NPs) upon illumination with a femtosecond (fs) pulsed laser at 1300 nm excitation wavelength is an effective approach for their identification in their biological context. The emission from spectral features of these CPs was investigated with time-domain fluorescence lifetime imaging (FLIM) to further support their identification. This study is performed for different types of CPs embedded in agarose gel as well as in in vitro mammalian cells. The unique nonlinear emissive behavior of CP NPs used for their label-free identification is further complementary with fluorophores typically used for specific staining of biological samples thus providing the relevant bio-context.

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Metal particles in mucus and hypertrophic tissue of the inferior nasal turbinates from the human upper respiratory tract

Cited by 5 publications

References 46 publications

Solid Anorganic Particles and Chronic Rhinosinusitis: A Histopathology Study

Solid Anorganic Particles and Chronic Rhinosinusitis: A Histopathology Study

Energy-Dispersive X-ray Spectroscopic Investigation of Failed Dental Implants Associated with Odontogenic Maxillary Sinusitis

Label-Free Identification of Carbonaceous Particles Using Nonlinear Optical Microscopy

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