Metal oxides and annealed metals as alternatives to metal salts for fixed-ratio metal mixture ecotoxicity tests in soil

Renaud, Mathieu; Cousins, Mark; Awuah, Kobby Fred; Jegede, Olugbemiro J.; Hale, Beverley; Sousa, José Paulo; Siciliano, Steven D.

doi:10.1371/journal.pone.0229794

Cited by 6 publications

(1 citation statement)

References 49 publications

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“…Whether or not whole mixture toxicity is additive of its components can be a function of the ratio of their concentrations (Li et al 2017; Renaud et al 2020). The contaminants of concern in the soils at both these sites are Ni and Cu, but the ratios are quite different: In soils from Sudbury, the ratio is about 1:1, whereas for Port Colborne, soil [Ni] is 5 to 10 times higher than soil [Cu].…”

Section: Resultsmentioning

confidence: 99%

Is assuming additivity of single‐metal toxicity thresholds a conservative approach to assessing risk of ecotoxicity from elevated soil concentrations of cobalt, copper, and nickel at contaminated sites?

Gopalapillai

Siciliano

Hale

2021

Integr Envir Assess & Manag

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Multiple metal‐impacted soils are often realistic scenarios for risk assessments, but tools to address these are currently lacking. The objective of this work was to evaluate whether assuming concentration addition (CA) of metal mixture effects was conservative for prospective risk assessment of soils that were elevated mainly in Ni and Cu and somewhat with Co, Pb, or As. Observed whole mixture toxicity for field soils with aged metal mixtures was compared to the expected whole mixture toxicity, assuming additivity of prospective single‐metal thresholds (“toxic units”) for the mixture components. Bioavailability‐adjusted single‐metal toxicity thresholds expected for those field soils were the median hazard concentration affecting 5% of species (HC5‐50) from the predicted no‐effect concentration (PNEC) calculator and calculated from the species‐specific dose–response multiple linear relationships (MLRs), all from the European Union Registration, Evaluation, Authorisation and Restriction of Chemicals (EU REACH) dossiers for metals. Generic single‐metal toxicity thresholds were based on Canadian Council of Ministers of the Environment soil quality guidelines (CCME SQGs) for agricultural soils. Observed toxicity thresholds were from the community‐based risk assessments conducted for Port Colborne and Sudbury, Ontario, Canada. Mostly, prospective single‐metal toxicity thresholds were protective relative to the observed toxicity, although that was species or ecological process dependent. The bioavailability‐adjusted single‐metal thresholds were less conservative than the CCME SQG method, even though the former is based on site‐specific EC10 values, and the latter is based on generic EC25 values. When within‐site variability in soil properties was used to calculate the 5th and 95th CI for the HC5 sum of toxic units (∑TUs), CA was conservative for far fewer endpoints. In addition, the prospective ∑TUs were more conservative predictions of the observed whole mixture toxicities for Port Colborne soils than for Sudbury soils. The most appropriate balance of accuracy and conservatism for identifying low‐level risk of the whole mixtures in these soils appeared to be the bioavailability‐adjusted HC5‐50, which was applicable to many endpoints and 2 quite different exposure concentration ratios. Integr Environ Assess Manag 2021;17:753–766. © 2020 SETAC

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Section: Resultsmentioning

confidence: 99%

Is assuming additivity of single‐metal toxicity thresholds a conservative approach to assessing risk of ecotoxicity from elevated soil concentrations of cobalt, copper, and nickel at contaminated sites?

Gopalapillai

Siciliano

Hale

2021

Integr Envir Assess & Manag

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Effects of cadmium and copper mixtures on antibiotic resistance genes in rhizosphere soil

Pan

Zheng

et al. 2023

Ecotoxicology and Environmental Safety

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Response addition is more protective of biogeochemical cycles of carbon and phosphorus compared to concentration addition

Awuah

Jegede

Cousins

et al. 2022

Environmental Pollution

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Metal oxides and annealed metals as alternatives to metal salts for fixed-ratio metal mixture ecotoxicity tests in soil

Abstract: Metal oxides and annealed metals as alternatives to metal salts for fixed-ratio metal mixture ecotoxicity tests in soil. PLoS ONE 15(3): e0229794.

Cited by 6 publications

References 49 publications

Is assuming additivity of single‐metal toxicity thresholds a conservative approach to assessing risk of ecotoxicity from elevated soil concentrations of cobalt, copper, and nickel at contaminated sites?

Is assuming additivity of single‐metal toxicity thresholds a conservative approach to assessing risk of ecotoxicity from elevated soil concentrations of cobalt, copper, and nickel at contaminated sites?

Effects of cadmium and copper mixtures on antibiotic resistance genes in rhizosphere soil

Response addition is more protective of biogeochemical cycles of carbon and phosphorus compared to concentration addition

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