Metal-oxide gas sensors for exhaled-breath analysis: a review

Yang, Daejeong; Ramu, A.G.; Telmenbayar, Lkhagvaa; Choi, Dai Hyuk

doi:10.1088/1361-6501/ac03e3

Cited by 35 publications

(26 citation statements)

References 136 publications

(59 reference statements)

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“…The sensitivity, selectivity, and stability of the MOS sensors are determined by several factors [ 8 , 89 ], as indicated in Figure 6 . This multi-factor dependence provides liberty to tailor the sensors as per the requirement of the application.…”

Section: Sensing Methodologies For Breath Analysismentioning

confidence: 99%

Section: Sensing Methodologies For Breath Analysismentioning

confidence: 99%

“…Keyto is another reported device based on the nanostructured semiconducting metal oxide core selective to acetone [88]. The sensitivity, selectivity, and stability of the MOS sensors are determined by several factors [8,89], as indicated in Figure 6. This multi-factor dependence provides liberty to tailor the sensors as per the requirement of the application.…”

Section: Mos Sensorsmentioning

confidence: 99%

“…There has been research tackling these problems and selecting suitable materials for the fabrication of sensors satisfying the requirements of an inexpensive portable device. The sensitivity, selectivity, and stability of the MOS sensors are determined by several factors [8,89], as indicated in Figure 6. This multi-factor dependence provides liberty to tailor the sensors as per the requirement of the application.…”

Section: Mos Sensorsmentioning

confidence: 99%

“…As evident from the table, the rapid response and recovery time makes these sensors compatible for real-time analysis of exhaled breath. Several other reviews focus on MOS sensors for exhaled breath analysis [11,89,97]. Das et al prepared a highly sensitive, fast, and stable (negligible change in base resistance for at least six months) cobalt chromite thick film-based trace acetone sensor [92].…”

Section: Mos Sensorsmentioning

confidence: 99%

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Exhaled Breath Analysis for Diabetes Diagnosis and Monitoring: Relevance, Challenges and Possibilities

et al. 2021

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With the global population prevalence of diabetes surpassing 463 million cases in 2019 and diabetes leading to millions of deaths each year, there is a critical need for feasible, rapid, and non-invasive methodologies for continuous blood glucose monitoring in contrast to the current procedures that are either invasive, complicated, or expensive. Breath analysis is a viable methodology for non-invasive diabetes management owing to its potential for multiple disease diagnoses, the nominal requirement of sample processing, and immense sample accessibility; however, the development of functional commercial sensors is challenging due to the low concentration of volatile organic compounds (VOCs) present in exhaled breath and the confounding factors influencing the exhaled breath profile. Given the complexity of the topic and the skyrocketing spread of diabetes, a multifarious review of exhaled breath analysis for diabetes monitoring is essential to track the technological progress in the field and comprehend the obstacles in developing a breath analysis-based diabetes management system. In this review, we consolidate the relevance of exhaled breath analysis through a critical assessment of current technologies and recent advancements in sensing methods to address the shortcomings associated with blood glucose monitoring. We provide a detailed assessment of the intricacies involved in the development of non-invasive diabetes monitoring devices. In addition, we spotlight the need to consider breath biomarker clusters as opposed to standalone biomarkers for the clinical applicability of exhaled breath monitoring. We present potential VOC clusters suitable for diabetes management and highlight the recent buildout of breath sensing methodologies, focusing on novel sensing materials and transduction mechanisms. Finally, we portray a multifaceted comparison of exhaled breath analysis for diabetes monitoring and highlight remaining challenges on the path to realizing breath analysis as a non-invasive healthcare approach.

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Section: Sensing Methodologies For Breath Analysismentioning

confidence: 99%

Section: Sensing Methodologies For Breath Analysismentioning

confidence: 99%

Section: Mos Sensorsmentioning

confidence: 99%

Section: Mos Sensorsmentioning

confidence: 99%

Section: Mos Sensorsmentioning

confidence: 99%

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Exhaled Breath Analysis for Diabetes Diagnosis and Monitoring: Relevance, Challenges and Possibilities

et al. 2021

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Infrared Non‐Invasive Exhaled Biomarker Sensing: A Review

Ranu,

Rahman

et al. 2023

Advanced Sensor Research

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Exhaled breath analysis is considered an effective tool for diagnosing the patient's metabolic status because of its non‐invasive nature. Gas chromatography‐mass spectrometry (GC‐MS) and other mass spectrometry techniques are widely used for exhaled breath analysis. Nevertheless, the requirement of a handheld device for real‐time analysis and rapid processing time of multiple samples leads to advancing infrared (IR) based breath gas sensing techniques. Herein, the IR gas sensing technologies are discussed with a focus on non‐dispersive infrared (NDIR), photoacoustic (PAS), and tunable diode laser absorption spectroscopy (TDLAS) gas sensing technologies because of their highly selective gas detection among compound gases (mixture of VOCs), as well as their corresponding sensing mechanisms and characteristics, for real‐time monitoring of exhaled biomarkers. Carbon dioxide, acetone, ammonia, nitric oxide, methane, and ethylene are the significant biomarkers elaborated in this work with their respective clinical applications and the significance of non‐invasive real‐time monitoring using IR detectors. Challenges in selectivity and clinical trials leads to focus on this review. Current market analysis, present status of different techniques to detect specific biomarkers and other challenges with their possible solutions discussed in this review aid in developing highly selective IR‐based handheld breath VOC analyzers for early diagnosis and screening.

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On‐Chip Annealing Using Embedded Micro‐Heater for Highly Sensitive and Selective Gas Detection

Park,

Shin,

Jung

et al. 2024

Advanced Science

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The demand for gas sensing systems that enable fast and precise gas recognition is growing rapidly. However, substantial challenges arise from the complex fabrication process of sensor arrays, time‐consuming data transmission to an external processor, and high energy consumption in multi‐stage data processing. In this study, a gas sensing system using on‐chip annealing for fast and power‐efficient gas detection is proposed. By utilizing a micro‐heater embedded in the gas sensor, the sensing material of adjacent sensors in the same substrate can be easily varied without further fabrication steps. The response to oxidizing gas is constrained in metal oxide (MOX) sensing material with small grain sizes, as the depletion width of grain cannot extend beyond the grain size during the gas reaction. On the other hand, the response to reducing gases and humidity, which decrease the depletion width, is less affected by grain sizes. A readout circuit integrating a differential amplifier and dual FET‐type gas sensors effectively emphasizes the response to oxidizing gases by canceling the response to reducing gases and humidity. The selective on‐chip annealing method is applicable to various MOX sensing materials, demonstrating its potential for application in commercial fields due to its simplicity and expandability.

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Metal-oxide gas sensors for exhaled-breath analysis: a review

Cited by 35 publications

References 136 publications

Exhaled Breath Analysis for Diabetes Diagnosis and Monitoring: Relevance, Challenges and Possibilities

Exhaled Breath Analysis for Diabetes Diagnosis and Monitoring: Relevance, Challenges and Possibilities

Infrared Non‐Invasive Exhaled Biomarker Sensing: A Review

On‐Chip Annealing Using Embedded Micro‐Heater for Highly Sensitive and Selective Gas Detection

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