Metal–organic gel coupled entropy-driven circuit for fluorescence detection of miR-155

Cao, Li; Wang, Yao; Bai, Yan; Jiang, Yong; Li, Chun Mei; Li, Yuan Fang; Huang, Chengzhi; Zhen, Shu Jun

doi:10.1039/d2tc03857a

Cited by 3 publications

(1 citation statement)

References 34 publications

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“…miR-155: Inspired by the previous reports, [216] an investigation integrated benzimidazole-based ligand Cu-based MOG having an entropy-driven circuit (EDC) to discern miR-155, representing a departure from conventional MOG-focused sensing methodologies. [217] Utilizing an enzyme-free amplification method, incorporated a three-strand duplex (TD) containing a modified output strand (OS) tagged with 6-carboxyfluorescein (FAM). Upon encountering miR-155, activation of the EDC triggered the release of the OS from a hybrid state to a free state.…”

Section: Prostate-specific Antigen (Psa)mentioning

confidence: 99%

An Encyclopedic Compendium on Chemosensing Supramolecular Metal‐Organic Gels

Sharma,

Kaur,

Singh

2024

Chemistry An Asian Journal

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Chemosensing, an interdisciplinary scientific domain, plays a pivotal role ranging from environmental monitoring to healthcare diagnostics and (inter)national security. Metal‐organic gels (MOGs) are recognized for their stability, selectivity, and responsiveness, making them valuable for chemosensing applications. Researchers have explored the development of MOGs based on different metal ions and ligands, allowing for tailored properties and sensitivities, and have even demonstrated their applications as portable sensors such as paper‐based test strips for practical use. Herein, several studies related to MOGs development and their applications in the chemosensing field via UV‐visible or luminance along with electrochemical based are presented. These papers explored MOGs as versatile materials with their use in sensing bio or environmental analytes. This review provides a foundational understanding of key concepts, methodologies, and recent advancements in this field, fostering the scientific community.

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Section: Prostate-specific Antigen (Psa)mentioning

confidence: 99%

An Encyclopedic Compendium on Chemosensing Supramolecular Metal‐Organic Gels

Sharma,

Kaur,

Singh

2024

Chemistry An Asian Journal

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Novel litchi-like Au–Ag nanospheres driven dual-readout lateral flow immunoassay for sensitive detection of pyrimethanil

Shu,

Guo,

Zhang

et al. 2024

Food Chemistry

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High-Sensitivity Homogeneous Detection of miRNA-155 Governed by DNA Walker-Regulated Surface DNA Density of Magnetic Electrochemiluminescence Nanoparticles

Lin,

Luo,

Luo

et al. 2024

Anal. Chem.

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Homogeneous electrochemiluminescence (ECL) has gained attention for its simplicity and stability. However, false positives due to solution background interference pose a challenge. To address this, magnetic ECL nanoparticles (Fe3O4@Ru@SiO2 NPs) were synthesized, offering easy modification, magnetic separation, and stable luminescence. These were utilized in an ECL sensor for miRNA-155 (miR-155) detection, with locked DNAzyme and substrate chain (mDNA) modified on their surface. The poor conductivity of long-chain DNA significantly impacts the conductivity and electron transfer capability of Fe3O4@Ru@SiO2 NPs, resulting in weaker ECL signals. Upon target presence, unlocked DNAzyme catalyzes mDNA cleavage, leading to shortened DNA chains and reduced density. In contrast, the presence of short-chain DNA has minimal impact on the conductivity and electron transfer capability of Fe3O4@Ru@SiO2 NPs. Simultaneously, the material surface’s electronegativity decreases, weakening the electrostatic repulsion with the negatively charged electrode, resulting in the system detecting stronger ECL signals. This sensor enables homogeneous ECL detection while mitigating solution background interference through magnetic separation. Within a range of 100 fM to 10 nM, the sensor exhibits a linear relationship between ECL intensity and target concentration, with a 26.91 fM detection limit. It demonstrates high accuracy in clinical sample detection, holding significant potential for clinical diagnostics. Future integration with innovative detection strategies may further enhance sensitivity and specificity in biosensing applications.

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Metal–organic gel coupled entropy-driven circuit for fluorescence detection of miR-155

Abstract: Owing to the simple and convenient synthesis, the application of metal-organic gel (MOG) in fluorescence detection has been increasingly studied. However, most relevant studies are based on the fluorescence changes...

Cited by 3 publications

References 34 publications

An Encyclopedic Compendium on Chemosensing Supramolecular Metal‐Organic Gels

An Encyclopedic Compendium on Chemosensing Supramolecular Metal‐Organic Gels

Novel litchi-like Au–Ag nanospheres driven dual-readout lateral flow immunoassay for sensitive detection of pyrimethanil

High-Sensitivity Homogeneous Detection of miRNA-155 Governed by DNA Walker-Regulated Surface DNA Density of Magnetic Electrochemiluminescence Nanoparticles

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