Metal-Organic Frameworks: Versatile Platforms for Biomedical Innovations

Abstract

This review article explores the multiple applications and potential of metal-organic frameworks (MOFs) in the biomedical field. With their highly versatile and tunable properties, MOFs present many possibilities, including drug delivery, biomolecule recognition, biosensors, and immunotherapy. Their crystal structure allows precise tuning, with the ligand typology and metal geometry playing critical roles. MOFs’ ability to encapsulate drugs and exhibit pH-triggered release makes them ideal candidates for precision medicine, including cancer treatment. They are also potential gene carriers for genetic disorders and have been used in biosensors and as contrast agents for magnetic resonance imaging. Despite the complexities encountered in modulating properties and interactions with biological systems, further research on MOFs is imperative. The primary focus of this review is to provide a comprehensive examination of MOFs in these applications, highlighting the current achievements and complexities encountered. Such efforts will uncover their untapped potential in creating innovative tools for biomedical applications, emphasizing the need to invest in the continued exploration of this promising field.

Amyloid detection in neurodegenerative diseases using MOFs

“…Adapting these biosensors to detect a broader range of amyloid variants may require significant modifications and additional research. 193…”

Chemiresistive Materials for Alcohol Vapor Sensing at Room Temperature

“…Metal organic frameworks (MOFs) are a class of nanoporous crystalline materials, produced by the assembly of metal ions or clusters and multidentate organic compounds, that assume the role of linkers in the obtained network [44]. The resulting MOFs structure is robust but flexible due to the presence of relatively weak coordination bonds and intermolecular forces.…”

Novel Hydrophobic Functionalized UiO-66 Series: Synthesis, Characterization, and Evaluation of Their Structural and Physical–Chemical Properties

“…To achieve a hydrophobic focus in the compound candidates, UiO-66-NH 2 was functionalized using the following benzoyl chlorides: p-and o-toluoyl chlorides, as well as 4and 2-fluorobenzoyl chlorides, resulting in compounds (1)(2)(3)(4), respectively (see Figure 1 for more details). The experimental conditions were under solvent-free methods, with the aim of generating eco-friendly and low-cost approaches to these types of compounds.…”

“…Metal–organic frameworks have been of attractive interest due to their wide versatility in a variety of research fields [ 1 , 2 , 3 , 4 , 5 ]. The well-thought-out synthesis and the use of proper metal nodes and organic ligands allow for the design of materials with tunable porosity, high surface areas, and great variability and shapes [ 6 , 7 ].…”