Metal–Organic Frameworks in Biomedicine

Horcajada, Patricia; Gref, Ruxandra; Baâti, Tarek; Allan, Phoebe K.; Maurin, Guillaume; Couvreur, Patrick; Férey, Gérard; Morris, Russell E.; Serre, Christian

doi:10.1021/cr200256v

Cited by 3,749 publications

(2,367 citation statements)

References 296 publications

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“…(See Fig.11) The temperature dependence experiments confirm this picture in which condensation is critical for reaction. At higher temperature of 50 ˚C and 40 ˚C, the framework is stable to 13 …”

Section: Condensationmentioning

confidence: 99%

“…5,6 The high surface areas, porosity and tunable structures make this type of materials very promising for a variety of applications including gas storage, separation, sensing, catalysis and drug delivery. 3,[7][8][9][10][11][12][13][14][15][16] Efforts have been done to explore MOFs as a sorbent for H 2 storage and CO 2 capture materials. H 2 storage in MOFs materials is usually achieved thorough fast physical adsorption onto the surface of pores with a large adsorption capacity.…”

Section: Introductionmentioning

confidence: 99%

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Stability and Hydrolyzation of Metal Organic Frameworks with Paddle-Wheel SBUs upon Hydration

et al. 2012

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Instability of most prototypical metal organic frameworks (MOFs) in the presence of moisture is always a limitation for industrial scale development. In this work, we examine the dissociation mechanism of microporous paddle wheel frameworks M(bdc)(ted) 0.5 [M=Cu, Zn, Ni, Co; bdc= 1,4-benzenedicarboxylate; ted= triethylenediamine] in controlled humidity environments. Combined in-situ IR spectroscopy, Raman, and Powder x-ray diffraction measurements show that the stability and modification of isostructual M(bdc)(ted) 0.5 compounds upon exposure to water vapor critically depend on the central metal ion. A hydrolysis reaction of water molecules with Cu-O-C is observed in the case of Cu(bdc)(ted) 0.5 . Displacement reactions of ted linkers by water molecules are identified with Zn(bdc)(ted) 0.5 and Co(bdc)(ted) 0.5 . In contrast, . Ni(bdc)(ted) 0.5 is less susceptible to reaction with water vapors than the other three compounds. In addition, the condensation of water vapors into the framework is necessary to initiate the dissociation reaction. These findings, supported by supported by first principles theoretical van der Waals density functional (vdW-DF) calculations of overall reaction enthalpies, provide the necessary information for determining operation conditions of this class of MOFs with paddle wheel secondary building units and guidance for developing more robust units.

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Section: Condensationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Stability and Hydrolyzation of Metal Organic Frameworks with Paddle-Wheel SBUs upon Hydration

et al. 2012

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“…Over the past two decades, MOFs have attracted extensive interest for their great potential in many applications such as gas separation/storage,11, 12, 13, 14, 15, 16, 17 catalysis,18, 19, 20 drug delivery,21 and luminescence sensing 2, 3, 4, 22, 23. As for conventional metal complexes, photoluminescence properties of MOFs can be finely tuned by rational selection of metal ions and design of organic ligands.…”

Section: Introductionmentioning

confidence: 99%

Photoluminescent Metal–Organic Frameworks for Gas Sensing

et al. 2016

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Luminescence of porous coordination polymers (PCPs) or metal–organic frameworks (MOFs) is sensitive to the type and concentration of chemical species in the surrounding environment, because these materials combine the advantages of the highly regular porous structures and various luminescence mechanisms, as well as diversified host‐guest interactions. In the past few years, luminescent MOFs have attracted more and more attention for chemical sensing of gas‐phase analytes, including common gases and vapors of solids/liquids. While liquid‐phase and gas‐phase luminescence sensing by MOFs share similar mechanisms such as host‐guest electron and/or energy transfer, exiplex formation, and guest‐perturbing of excited‐state energy level and radiation pathways, via various types of host‐guest interactions, gas‐phase sensing has its unique advantages and challenges, such as easy utilization of encapsulated guest luminophores and difficulty for accurate measurement of the intensity change. This review summarizes recent progresses by using luminescent MOFs as reusable sensing materials for detection of gases and vapors of solids/liquids especially for O2, highlighting various strategies for improving the sensitivity, selectivity, stability, and accuracy, reducing the materials cost, and developing related devices.

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“…[1][2][3][4][5][6][7] Among MOFs that permit reversible guest removal and uptake, most have a rigid pore structure reminiscent of harder inorganic porous materials such as zeolites. A recent estimate indicates that only around 100 out of some 20,000 reported MOFs exhibit breathing or flexible behaviour in response to external stimuli.…”

mentioning

confidence: 99%