Metal–organic frameworks for the storage and delivery of biologically active hydrogen sulfide

Abstract

Hydrogen sulfide is an extremely toxic gas that is also of great interest for biological applications when delivered in the correct amount and at the desired rate. Here we show that the highly porous metal-organic frameworks with the CPO-27 structure can bind the hydrogen sulfide relatively strongly, allowing the storage of the gas for at least several months. Delivered gas is biologically active in preliminary vasodilation studies of porcine arteries, and the structure of the hydrogen sulfide molecules inside the framework has been elucidated using a combination of powder X-ray diffraction and pair distribution function analysis.

Fundamental Aspects of H2S Adsorption on CPO-27-Ni

“…For CPO-27-Ni in interaction with H 2 S, structural features are in good agreement with the recently reported synchrotron X-ray data at room temperature 23 , with values for lattice parameters and volume lying within 1% and 2.5%, respectively. For the three structures, the average of the Ni-O bond distance in the framework and the Ni-Ni distances are also in good agreement with experimental data from different techniques 24,32 , despite a slight overestimation.…”

Understanding the adsorption mechanism of noble gases Kr and Xe in CPO-27-Ni, CPO-27-Mg, and ZIF-8

“…23,34 The activated material has a characteristic honeycomb structure composed of 1D channels with abundant open metal sites. The open metal sites were found to be preferable for the adsorption of many gases in CPO-27: O 2 and N 2 in CPO-27-Fe, 26 CO 2 in CPO-27-Ni 35 and CPO-27-Mg, 19 CH 4 in CPO-27-Mg, 36 H 2 S molecule in CPO-27-Ni, [37][38] and C 2 H 2 in CPO-27-Co, 39 C 2 H 2 , C 2 H 4 , C 2 H 6 , C 3 H 6 , and C 3 H 8 in CPO-27-Fe. 40 ZIF-8 belongs to the class of zeolitic imidazolate frameworks (ZIFs).…”

Metal-dioxidoterephthalate MOFs of the MOF-74 type: Microporous basic catalysts with well-defined active sites

“…[22] The high density of exposed metal ions in these materials has sparked much interest in the field of adsorption and the adsorptive separation of compounds such as CO, CO 2 , CH 4 , ethane, acetylene, propane, propylene or H 2 S. [20,[23][24][25][26][27][28][29][30][31] The existence of a family of isostructural materials has also allowed to study the specific role of the metal ion in these adsorption processes. [20,24,29,32] Reports of catalysis using M 2 dobdc are very limited hitherto; they focus on the role of the metal ion as a Lewis acid center, or in accelerating autoxidation reactions.…”