Metal-organic frameworks for efficient drug adsorption and delivery

Hyjek, Kornelia; Jodłowski, Przemysław J.

doi:10.58332/scirad2023v2i2a03

Cited by 4 publications

(3 citation statements)

References 266 publications

(507 reference statements)

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“…MOFs are a new group of highly porous materials. Considering their structure, namely the inorganic metallic part and the organic linker, it can be found that they have many unique features. − Characterized by high specific surface areas, high thermal and chemical stability, and through this, a variety of application possibilities. Low toxicity, high bioavailability, or biocompatibility enable the biomedical applications of MOFs.…”

Section: Introductionmentioning

confidence: 99%

Crystal Clear: Metal–Organic Frameworks Pioneering the Path to Future Drug Detox

Jodłowski,

Dymek,

Kurowski

et al. 2024

ACS Appl. Mater. Interfaces

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The growing number of acute drug abuse overdoses demands the development of innovative detoxification strategies for emergency purposes. In this study, an innovative approach for the application of porous Zr-based metal−organic frameworks for the treatment of acute overdoses of popular drugs of abuse including amphetamine, methamphetamine, cocaine, and MDMA is presented. A comprehensive approach determining the efficacy and the kinetics of drug removal, considering dosage, adsorption time, and adsorption mechanisms, was tested and corroborated with density functional theory (DFT) modeling. The experimental results showed high removal efficiency reaching up to 90% in the case of the application of the NU-1000 metal−organic framework. The difference Raman spectroscopy method presented in this study corroborated with DFT-based vibrational analysis allows the detection of drug adsorbed in the MOF framework even with as low a concentration as 5 mg/g. Additionally, the drug adsorption mechanisms were modeled with DFT, showing the π−π stacking in a vast majority of considered cases. The performance and influence on the living organisms were evaluated throughout the in vitro and in vivo experiments, indicating that Zr-based MOFs could serve as efficient, organic, safe drug adsorbents.

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Section: Introductionmentioning

confidence: 99%

Crystal Clear: Metal–Organic Frameworks Pioneering the Path to Future Drug Detox

Jodłowski,

Dymek,

Kurowski

et al. 2024

ACS Appl. Mater. Interfaces

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“…8 In fact, MOFs are applied in almost all types of applications, including the critical ones of drug delivery and medical treatments. [9][10][11][12] Consequently, our interest in developing suitable MOFs for environmental applications has grown. In this letter, we report on a novel zirconium-based MOF prepared under different conditions and characterized in terms of its nature, morphology, shape, size, and elemental analysis.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterisation of novel metal-organic frameworks (MOFs) based on zirconium and bicinchoninic acid

Albayati,

AL-dulaimy,

Jweeg

et al. 2024

10.5267/j.ccl

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Metal-organic frameworks (MOFs) are a relatively new class of materials of unique porous structures and exceptional properties. Currently, more than 110,000 types of MOFs have been reported among the countless possibilities. In this study, we have synthesised a novel MOF using zirconium chloride as the metal source and 4,4'-dicarboxy-2,2'-biquinoline (bicinchoninic acid disodium salt) as the linker, which reacted in N,N-Dimethylformamide (DMF) solvent. Three preparation methods were employed to prepare five types of the MOF, and they were compared to optimize the synthesis conditions. The resulting MOFs, named Zr-BADS, were characterised using scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), microscopy, and X-ray diffraction (XRD). By incorporating methanol into the preparation solvent, the surface area was increased to 396 m2/g. Additionally, the prepared MOFs exhibited amorphous shapes, with variations in size depending on the synthesis method. This research demonstrates the significance of the preparation method in controlling resulting particles’ properties.

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“…The chemistry of heterocyclic compounds is one of the most dynamically developing areas of science [1][2][3][4][5]. Among a number of compounds of this type, structures from the triazole group enjoy undying interest [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

On the Question of Zwitterionic Intermediates in the [3+2] Cycloaddition Reactions between Aryl Azides and Ethyl Propiolate

Dresler,

Woliński,

Wróblewska

et al. 2023

Molecules

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The molecular mechanism of the [3+2] cycloaddition reactions between aryl azides and ethyl propiolate was evaluated in the framework of the Molecular Electron Density Theory. It was found that independently of the nature of the substituent within the azide molecule, the cycloaddition process is realized via a polar but single-step mechanism. All attempts of localization as postulated earlier by Abu-Orabi and coworkers’ zwitterionic intermediates were not successful. At the same time, the formation of zwitterions with an “extended” conformation is possible on parallel reaction paths. The ELF analysis shows that the studied cycloaddition reaction leading to the 1,4-triazole proceeds by a two-stage one-step mechanism. It also revealed that both zwitterions are created by the donation of the nitrogen atom’s nonbonding electron densities to carbon atoms of ethyl propiolate.

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Metal-organic frameworks for efficient drug adsorption and delivery

Cited by 4 publications

References 266 publications

Crystal Clear: Metal–Organic Frameworks Pioneering the Path to Future Drug Detox

Crystal Clear: Metal–Organic Frameworks Pioneering the Path to Future Drug Detox

Synthesis and characterisation of novel metal-organic frameworks (MOFs) based on zirconium and bicinchoninic acid

On the Question of Zwitterionic Intermediates in the [3+2] Cycloaddition Reactions between Aryl Azides and Ethyl Propiolate

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