Metal-organic frameworks for advanced drug delivery

He, Siyu; Wu, Li; Li, Xue; Sun, Hongyu; Xiong, Tao; Liu, Jie; Huang, Chengxi; Xu, Huipeng; Sun, Hongqi; Chen, Weidong; Gref, Ruxandra; Zhang, Jiwen

doi:10.1016/j.apsb.2021.03.019

Cited by 268 publications

(168 citation statements)

References 291 publications

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“…MOFs also act as direct alternatives to conventional enzymes for enzymatic reactions. Serving as nanozymes, they can imitate the coordination envi- Moreover, other examples of MOFs used to encapsulate drugs include MIL-89 (Fe) of a uniform pore size (11 Å), which was used to entrap drugs like Ibuprofen and azidothymidine triphosphate [115]. Ibuprofen was also encapsulated by some other MOFs with different pore sizes, such as HKUST-1 with a pore size of 14.67Å, MOF-2 with a pore size of 21.2 Å, and MIL-53(Fe) with a pore size of 8.6Å [116,117].…”

Section: Biomedical Applications Of Mofsmentioning

confidence: 99%

Biomedical Applications of Metal−Organic Frameworks for Disease Diagnosis and Drug Delivery: A Review

2022

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Metal−organic frameworks (MOFs) are a novel class of porous hybrid organic−inorganic materials that have attracted increasing attention over the past decade. MOFs can be used in chemical engineering, materials science, and chemistry applications. Recently, these structures have been thoroughly studied as promising platforms for biomedical applications. Due to their unique physical and chemical properties, they are regarded as promising candidates for disease diagnosis and drug delivery. Their well-defined structure, high porosity, tunable frameworks, wide range of pore shapes, ultrahigh surface area, relatively low toxicity, and easy chemical functionalization have made them the focus of extensive research. This review highlights the up-to-date progress of MOFs as potential platforms for disease diagnosis and drug delivery for a wide range of diseases such as cancer, diabetes, neurological disorders, and ocular diseases. A brief description of the synthesis methods of MOFs is first presented. Various examples of MOF-based sensors and DDSs are introduced for the different diseases. Finally, the challenges and perspectives are discussed to provide context for the future development of MOFs as efficient platforms for disease diagnosis and drug delivery systems.

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Section: Biomedical Applications Of Mofsmentioning

confidence: 99%

Biomedical Applications of Metal−Organic Frameworks for Disease Diagnosis and Drug Delivery: A Review

2022

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“…Therefore, MOFs must be recognized for various applications, structured from naturally and chemically mediated essential elements that are competitive with the environment. However, in most research, non-toxic MOFs were preferred in intracellular imaging than toxic ones [ 39 , 40 ].…”

Section: Introductionmentioning

confidence: 99%

Zinc-Based Metal-Organic Frameworks in Drug Delivery, Cell Imaging, and Sensing

Ali

Meng

2021

Molecules

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The design and structural frameworks for targeted drug delivery of medicinal compounds and improved cell imaging have been developed with several advantages. However, metal-organic frameworks (MOFs) are supplemented tremendously for medical uses with efficient efficacy. These MOFs are considered as an absolutely new class of porous materials, extensively used in drug delivery systems, cell imaging, and detecting the analytes, especially for cancer biomarkers, due to their excellent biocompatibility, easy functionalization, high storage capacity, and excellent biodegradability. While Zn-metal centers in MOFs have been found by enhanced efficient detection and improved drug delivery, these Zn-based MOFs have appeared to be safe as elucidated by different cytotoxicity assays for targeted drug delivery. On the other hand, the MOF-based heterogeneous catalyst is durable and can regenerate multiple times without losing activity. Therefore, as functional carriers for drug delivery, cell imaging, and chemosensory, MOFs’ chemical composition and flexible porous structure allowed engineering to improve their medical formulation and functionality. This review summarizes the methodology for fabricating ultrasensitive and selective Zn-MOF-based sensors, as well as their application in early cancer diagnosis and therapy. This review also offers a systematic approach to understanding the development of MOFs as efficient drug carriers and provides new insights on their applications and limitations in utility with possible solutions.

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“…26 MOFs as Zn-MOFs and other systems can accumulate in the body and spleen and degrade into their constituent but are ultimately excreted in urine and faeces without any metabolization. 27 5-Fluorouracil (5FU) is one of the drugs used in chemotherapy treatments for tumours 28 such as oesophageal, stomach, ovarian, pancreatic and breast. 29 The studies focusing on MOF as drug delivery for 5FU 30,31 have been carried out by experimental [32][33][34] and theoretical techniques.…”

Section: Introductionmentioning

confidence: 99%