Metal–organic frameworks as efficient materials for drug delivery: Synthesis, characterization, antioxidant, anticancer, antibacterial and molecular docking investigation

Abstract

Metal-organic framework (MOF) nano particles are a class of promising porous nano materials for biomedical applications. Owing to its high loading potential and pH-sensitive degradation, most promising of the MOFs is the zeolitic imidazolate crystal framework (ZIF-8), a progressive useful material for small molecule distribution. Doxorubicin (DOX), designated as a classical drug, was jobwise entrapped in ZIF-8 nano particles. ZIF-8 nano particles, as a novel carrier, were used to monitor the release of the anticancer drug DOX and prevent it from dissipating before reaching its goal. ZIF-8 nano particles with encapsulated DOX (DOX@ZIF-8) can be synthesized in a single pot by incorporation of DOX into the reaction mixture. MOFs and the designed drug delivery (DOX@ZIF-8) system were characterized by Fourier transfer infrared, scanning electron microscopy, N 2 sorption isotherm and X-ray diffraction. The impact of MOFs and the engineered drug delivery system on the viability of human breast and liver cancer cell lines was evaluated. The loaded drug was released at pH 5 faster than at pH 7.4. The nano particles of ZIF-8 showed low cytotoxicity, while DOX@ZIF-8 showed high cytotoxicity to HepG-2 and MCF-7 cells compared with free DOX at the equivalent concentration of DOX of >12.5 μg/ml. These findings indicate that DOX@ZIF-8 nano particles are a promising method for the delivery of cancer cells to drugs. Furthermore, ZIF-8, DOX and encapsulated DOX@ZIF-8 compounds were screened for their potential antibacterial activities against pathogenic bacteria compared with standard antibiotics by the agar well diffusion technique. The results demonstrate that the DOX@ZIF-8 exhibits a strong inhibition zone against Gram-negative strains (Escherichia coli) in comparison with the reference drug gentamycin. The docking active site interactions were evaluated to predict the binding between DOX with the receptor of breast cancer 3hb5-oxidoreductase and liver cancer 2h80-lipid binding protein for anticancer activity.

Synthesis, Structural Investigations, Molecular Docking, and Anticancer Activity of Some Novel Schiff Bases and Their Uranyl Complexes

“…The results are shown in Table 13. The results clarified that uranyl complexes show better anticancer activities than ligands when both cells are examined [54][55][56][57][58][59].…”

“…The results are shown in Table 13. The results clarified that uranyl complexes show better anticancer activities than ligands when both cells are examined [54][55][56][57][58][59]. By comparison with the literature results [8][9][10][11][12] of the activity of uranyl complexes as anticancer agents for many different cell lines, it was found that the Schiff's base uranyl complexes that were prepared in this study have more effective IC50, which indicated less toxicity than previously reported results, which may be because this is the first study that investigated their effect against ovarian cancer and melanoma cell lines.…”

Outstanding Graphene Quantum Dots from Carbon Source for Biomedical and Corrosion Inhibition Applications: A Review

“…GQDs are a very promising substrate for drug delivery systems because of their excellent tunable chemical and physical properties, as well as the simple surface functionalization. Otherwise, there are dozens of published articles used as antimicrobial and anticancer treatments [20,39,[166][167][168][169]. The size-dependent coupling of graphene nanosheets with DNA molecules was reported that GQDs have a limited lateral dimension and the capacity of DNA molecules to intercalate is most apparent.…”

Rapid Electrochemical Quantification for In Vitro Release Trait of Ophthalmic Drug Loaded within Mucoadhesive Metal Organic Framework (MOF)

“…Metal organic framework is a relatively new class of material, composed of organic-inorganic hybrid, possessing high porosity, enhanced inner surface area, abundant functional groups, biocompatibility and biodegradability, and reported to be a potential vehicle for manageable medication conveyance for malignant growth treatment, pathogenic contamination, etc. [15,16] In the present investigation, we have prepared [Fe 3 O(BDC-NH 2 ) 3 ](FeMOF) as a delivery vehicle for sustained release of Timolol Maleate (TM), a non-selective betaadrenoceptor antagonist used for glaucoma treatment to reduce intraocular pressure (IOP) and has been considered as a model ophthalmic drug to study sustained release. Synthesis of (FeMOF) has been carried out by the solvothermal method through coordination reaction between Fe-salt and 2-amino terephthalic acid.…”