Metal–organic frameworks as a therapeutic strategy for lung diseases

Zheng, Yu; Zhao, Yuxin; Bai, Mengting; Gu, Hui; Li, Xiaofang

doi:10.1039/d2tb00690a

Cited by 14 publications

(11 citation statements)

References 198 publications

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“…Despite recent advances in the treatment of multiple lung infections in the clinic, the opportunity to create targeted nanosystems that are easier to use in the clinic has not been realised. 343 Any advancement in pulmonary nanomedicine delivery systems should aim to make treatment as effective as possible while minimizing unintended side effects. Xia et al 344 found that targeting of platelet-derived extracellular vesicles (PEVs) can deliver [5-(p-fluorophenyl)-2-uryl] thiophen-3-formamide (TPCA-1) into the lung to quell the local CS in acute lung injury (Figure 20).…”

Section: Lung Targeted Nanomedicine Deliverymentioning

confidence: 99%

Section: Multiple Therapies Including Nanotherapy For Management Of Csmentioning

confidence: 99%

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COVID‐19 cooling: Nanostrategies targeting cytokine storm for controlling severe and critical symptoms

Zheng,

Li,

et al. 2023

Medicinal Research Reviews

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As severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) variants continue to wreak havoc worldwide, the “Cytokine Storm” (CS, also known as the inflammatory storm) or Cytokine Release Syndrome has reemerged in the public consciousness. CS is a significant contributor to the deterioration of infected individuals. Therefore, CS control is of great significance for the treatment of critically ill patients and the reduction of mortality rates. With the occurrence of variants, concerns regarding the efficacy of vaccines and antiviral drugs with a broad spectrum have grown. We should make an effort to modernize treatment strategies to address the challenges posed by mutations. Thus, in addition to the requirement for additional clinical data to monitor the long‐term effects of vaccines and broad‐spectrum antiviral drugs, we can use CS as an entry point and therapeutic target to alleviate the severity of the disease in patients. To effectively combat the mutation, new technologies for neutralizing or controlling CS must be developed. In recent years, nanotechnology has been widely applied in the biomedical field, opening up a plethora of opportunities for CS. Here, we put forward the view of cytokine storm as a therapeutic target can be used to treat critically ill patients by expounding the relationship between coronavirus disease 2019 (COVID‐19) and CS and the mechanisms associated with CS. We pay special attention to the representative strategies of nanomaterials in current neutral and CS research, as well as their potential chemical design and principles. We hope that the nanostrategies described in this review provide attractive treatment options for severe and critical COVID‐19 caused by CS.

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Section: Lung Targeted Nanomedicine Deliverymentioning

confidence: 99%

Section: Multiple Therapies Including Nanotherapy For Management Of Csmentioning

confidence: 99%

COVID‐19 cooling: Nanostrategies targeting cytokine storm for controlling severe and critical symptoms

Zheng,

Li,

et al. 2023

Medicinal Research Reviews

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“…Metal ions are of concern due to their significant impact on the health and disease of living organisms. [1,2] Among them, iron is the most abundant essential transition metal ion in the human body and plays a vital role in biological and environmental systems. [3][4][5] Excess or deficiency of ferric ions can lead to various diseases such as heart failure, liver damage, kidney damage, and diabetes.…”

Section: Introductionmentioning

confidence: 99%

“…Metal ions are of concern due to their significant impact on the health and disease of living organisms [1,2] . Among them, iron is the most abundant essential transition metal ion in the human body and plays a vital role in biological and environmental systems [3–5] .…”

Section: Introductionmentioning

confidence: 99%

Colorimetric Fluorescence of a 2,4,5‐Triaryl Imidazole‐Based Sensor for the Selective Detection of Iron

Wang,

Ren,

Liu

et al. 2024

ChemistrySelect

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Two imidazole‐based color‐changing fluorescent probes 4‐(4,5‐bis(4‐chlorophenyl)‐1H‐imidazol‐2‐yl)‐N, N‐diphenylaniline (CIN) and 4‐(4,5‐di(furan‐2‐yl)‐1H‐imidazol‐2‐yl)‐N, N‐diphenylaniline (FIN) were synthesized and characterized. The new probes CIN and FIN exhibit excellent selectivity and sensitivity towards Fe3+ with relatively low detection limits (0.26 μM and 0.10 μM) and strong anti‐interference properties. Both the probes CIN and FIN complex 1 : 1 with Fe3+ ion, and the complexation constants were 1.165×105 M−1 (CIN) and 1.899×105 M−1 (FIN), respectively. Moreover, CIN and FIN could be recycled by EDTA and could effectively monitor Fe3+ ions at pH 4–10, which ensures the sensor‘s potential for detecting Fe3+ in actual aqueous solutions. The probes were further applied to the detection of Fe3+ in the actual reaction of Fe2+ oxidation, and the filter paper and the probe solution are combined to make an indicator to detect Fe3+ more conveniently and quickly.

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“…Metal–organic frameworks (MOF) are formed via coordinate bonding between organic linkers and metal ions. MOFs synthesized using a variety of materials and exhibiting versatile functionalities have been applied in environmental science, sensor separation, catalysis, and drug delivery. − However, MOFs used for drug delivery and their building blocks should be biodegradable . For example, sugars such as starch and lactose are safe and biodegradable.…”

Section: Introductionmentioning

confidence: 99%

Drug-Facilitated Crystallization of Spray-Dried CD-MOFs with Tunable Morphology, Porosity, And Dissolution Profile

Kadota

Tse

Fujita

et al. 2023

ACS Appl. Bio Mater.

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Metal–organic frameworks (MOFs) with versatile functionalities have applications in environmental science, sensor separation, catalysis, and drug delivery. In particular, MOFs used in drug delivery should be biodegradable and easy to control. In this study, spray-dried cyclodextrin-based MOFs (CD-MOFs) with tunable crystallinity, porosity, and dissolution properties were fabricated. The spray-drying precursor properties, such as ethanol volume ratio, incubation time, and precursor concentration, were optimized for controlled crystallization. On the basis of the morphology, X-ray diffraction peak intensity, and specific surface areas of the spray-dried CD-MOF products, they were categorized as amorphous, partially crystalline, and highly crystalline. An active pharmaceutical ingredient ketoconazole (KCZ) was introduced into the precursor to prepare KCZ-containing CD-MOFs. The surface areas of these products were greater by 3-fold (292 m2/g) than that of the plain CD-MOF (94.1 m2/g) prepared using the same parameters. The presence of KCZ in the hydrophobic cavity between the two γ-CD molecules was correlated to the CD-MOF crystal growth. Additionally, CD-MOF particles exhibited different dissolution behaviors on the basis of the position of KCZ in the MOF. These spray-dried CD-MOFs with tunable morphology, specific surface area, and dissolution could have potential applications in various fields.

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Metal–organic frameworks as a therapeutic strategy for lung diseases

Abstract: This review focuses on the design and application of MOF-based drugs against lung diseases, and discusses the possibility of preparing MOF-based inhalable formulations and the challenges and opportunities of MOFs in clinical applications targeting lung diseases.

Cited by 14 publications

References 198 publications

COVID‐19 cooling: Nanostrategies targeting cytokine storm for controlling severe and critical symptoms

COVID‐19 cooling: Nanostrategies targeting cytokine storm for controlling severe and critical symptoms

Colorimetric Fluorescence of a 2,4,5‐Triaryl Imidazole‐Based Sensor for the Selective Detection of Iron

Drug-Facilitated Crystallization of Spray-Dried CD-MOFs with Tunable Morphology, Porosity, And Dissolution Profile

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