2018
DOI: 10.1039/c8tb01899e
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Metal–organic framework nanoparticles for arsenic trioxide drug delivery

Abstract: As2O3 was introduced as an anion into MOF nanoparticles via a postsynthetic ligand exchange; material cytotoxicity was investigated in vitro.

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Cited by 34 publications
(36 citation statements)
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“…63,64 As noted in Ref. 65 ), which is linked to six N-donor atoms of six different ligands, and by four peripheral tetrahedrally coordinated zinc ions (Zn t ). Each of the latter are linked to three N-donor atoms of three different ligands.…”
Section: Resultsmentioning
confidence: 95%
“…63,64 As noted in Ref. 65 ), which is linked to six N-donor atoms of six different ligands, and by four peripheral tetrahedrally coordinated zinc ions (Zn t ). Each of the latter are linked to three N-donor atoms of three different ligands.…”
Section: Resultsmentioning
confidence: 95%
“…In order to improve its therapeutic effect and reduce its toxic side effects, MOFs can be used as the carrier materials. 66 Ettlinger et al prepared arsenic loaded As@ZIF-8 nanoparticles and then modied their surface with amino-functionalized polyethylene glycol derivatives (PEG-NH 2 ) to obtain PEG-NH 2 @As@ZIF-8, which can improve the biocompatibility and stability of As@ZIF-8. In vitro release experiments revealed that under the condition of pH ¼ 7.4, the release amount of arsenic in As@ZIF-8 and PEG-NH 2 @As@ZIF-8 aer 24 h was 15.5% and 7.2%, respectively, and under the condition of pH ¼ 6, the release of arsenic in 24 h was 29.4% and 20.2%, respectively.…”
Section: Zif-8@mesoporous Nanoparticle Compositesmentioning
confidence: 99%
“…4,5 While the gas separation performance of nanoMOFs has attracted industrial interest, their improved activities as atomically dened catalysts and drug delivery agents has opened emerging areas of research. [6][7][8] Despite advances in nanoMOF applications, accurate models are still needed to probe fundamental mechanistic details and reliably control particle sizes.…”
Section: Introductionmentioning
confidence: 99%