Metal–organic framework nanoparticles for arsenic trioxide drug delivery

Ettlinger, Romy; Sönksen, Marthe; Graf, Monika; Moreno, Natàlia; Denysenko, Dmytro; Volkmer, Dirk; Kerl, Kornelius; Bunzen, Hana

doi:10.1039/c8tb01899e

Cited by 31 publications

(33 citation statements)

References 37 publications

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“…63,64 As noted in Ref. 65 ), which is linked to six N-donor atoms of six different ligands, and by four peripheral tetrahedrally coordinated zinc ions (Zn t ). Each of the latter are linked to three N-donor atoms of three different ligands.…”

Section: Resultsmentioning

confidence: 95%

Supercooled water confined in a metal-organic framework

et al. 2020

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Within the so-called "no-man's land" between about 150 and 235 K, crystallization of bulk water is inevitable. The glasslike freezing and a liquid-to-liquid transition of water, predicted to occur in this region, can be investigated by confining water in nanometersized pores. Here we report the molecular dynamics of water within the pores of a metalorganic framework using dielectric spectroscopy. The detected temperature-dependent dynamics of supercooled water matches that of bulk water as reported outside the borders of the no-man's land. In confinement, a different type of water is formed, nevertheless still undergoing a glass transition with considerable molecular cooperativity. Two different length scales seem to exist in water: A smaller one, of the order of 2 nm, being the cooperativity length scale governing glassy freezing, and a larger one (> 2 nm), characterizing the minimum size of the hydrogen-bonded network needed to create "real" water with its unique dynamic properties.

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Section: Resultsmentioning

confidence: 95%

Supercooled water confined in a metal-organic framework

et al. 2020

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“…In order to improve its therapeutic effect and reduce its toxic side effects, MOFs can be used as the carrier materials. 66 Ettlinger et al prepared arsenic loaded As@ZIF-8 nanoparticles and then modied their surface with amino-functionalized polyethylene glycol derivatives (PEG-NH 2 ) to obtain PEG-NH 2 @As@ZIF-8, which can improve the biocompatibility and stability of As@ZIF-8. In vitro release experiments revealed that under the condition of pH ¼ 7.4, the release amount of arsenic in As@ZIF-8 and PEG-NH 2 @As@ZIF-8 aer 24 h was 15.5% and 7.2%, respectively, and under the condition of pH ¼ 6, the release of arsenic in 24 h was 29.4% and 20.2%, respectively.…”

Section: Zif-8@mesoporous Nanoparticle Compositesmentioning

confidence: 99%

Synthesis and modification of ZIF-8 and its application in drug delivery and tumor therapy

et al. 2020

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“…4,5 While the gas separation performance of nanoMOFs has attracted industrial interest, their improved activities as atomically dened catalysts and drug delivery agents has opened emerging areas of research. [6][7][8] Despite advances in nanoMOF applications, accurate models are still needed to probe fundamental mechanistic details and reliably control particle sizes.…”

Section: Introductionmentioning

confidence: 99%