Metal–organic framework (MOF) hybridized gold nanoparticles as a bifunctional nanozyme for glucose sensing

Abstract

Inspired by natural enzymes that possess multiple catalytic activities, here we develop a bifunctional metal-organic frame-work (MOF) for biosensing applications. Ultrasmall gold nano-particles (AuNPs) are grown in the internal cavities...

Mercury-Mediated Epitaxial Accumulation of Au Atoms for Stained Hydrogel-Improved On-Site Mercury Monitoring

“…The calculation results show that the reaction Gibbs free energy changes of Au 3+ , Hg 2+ , Pb 2+ , Zn 2+ , Fe 3+ , and Ni 2+ ions dropped on the Au {111} surface (Figures a and S6). − Significantly, among those studied metal ions, only Au 3+ , Hg 2+ , and Pb 2+ ions have minus Gibbs free energy changes in the reaction, with Au 3+ being the lowest and Hg 2+ being the second. From a thermodynamic perspective, the reduction performance of Hg 2+ ions surpasses that of Pb 2+ ions, corresponding to the preferential formation of Hg atoms at Au surfaces.…”

“…The involvement of heterogeneous seeds enables the high uniformity of plasmonic Au nanohybrids. − To improve the hydrogel-based analysis methods and uncover the target-reliant plasmonic recognition mechanism, polymeric CDs with reduction properties are synthesized via a hydrothermal reaction, which were prefilled on the hydrogel backbone to launch the growth of Au NPs according to the redox–reductant reaction between CDs and HAuCl 4 . More importantly, this method enables the transfer of the aqueous-phase reaction into the hydrogel phase, which simplifies the operation and realizes the LSPR signal amplification strategy to enhance the stability and sensitivity of colorimetric sensing of Au NPs (Scheme ).…”

Quantification of Glycated Hemoglobin in Total Hemoglobin by a Simultaneous Dual-Signal Acquisition Approach

“…1.00 mL of gold nanoparticles was mixed with 1.00 mL of ZIF-8@Ferrocene, stirred for 2 h, centrifuged (8000 r min –1 ), and dispersed in 2.00 mL of deionized water (ZIF-8@Ferrocene/Au). Finally, 1.00 mL of MBA (1.00 mg mL –1 ) was added to ZIF-8@Ferrocene/Au and washed by centrifugation to obtain ZIF-8@Ferrocene/Au-MBA …”

“…Diabetes is a prevalent chronic metabolic disorder characterized by abnormally elevated blood glucose levels. , According to the latest data from the International Diabetes Federation, approximately 5.37 billion adults worldwide have diabetes, representing 10.2% of the global adult population. , Prolonged hyperglycemia in diabetic patients may lead to serious complications, including cardiovascular disease, neuropathy, nephropathy, and eye disease. − Therefore, controlling the blood glucose level and undergoing regular diabetes monitoring are crucial for diabetics. The traditional methods of monitoring diabetes primarily involve assessing a patient’s diabetes management through the measurement of blood glucose levels. − However, it should be noted that the blood glucose level is not considered as an ideal long-term indicator of diabetes due to its susceptibility to various influencing factors, including diet, physical activity, stress, and other variables. , Furthermore, the assessment of blood glucose levels necessitates frequent blood sampling and measurements, which can be both inconvenient and potentially harmful for patients. ,, In contrast, glycated hemoglobin (HbA 1c ), as a nonenzymatic reaction metabolite, remains unaffected by short-term glucose concentration fluctuations, providing a more accurate representation of an average blood glucose level over 2–3 months. , Consequently, it is considered one of the preferred indicators for long-term diabetes monitoring. Additionally, HbA 1c measurement avoids the need for multiple blood collections, reducing patient inconvenience, and improving compliance compared to other monitoring methods. , …”

Fluorescence-Enhanced Tb-MOF for Highly Sensitive and Selective Detection of Ammonia Nitrogen in Groundwater

“…MOFs have been reported to have many excellent advantages such as tunable structures, abundant groups, high porosities, large surface areas, and good thermal stabilities. The versatility and potential of MOFs were demonstrated as next-generation materials for catalysis, gas storage, supercapacitors, absorbents, separation, and nanosensors . Due to the narrow emission band, long lifespan, adjustable luminescence characteristics, and stable fluorescence of MOFs, their use in the fluorescence sensing field developed rapidly .…”