Metal–Organic Framework‐Derived Copper Nanoparticle@Carbon Nanocomposites as Peroxidase Mimics for Colorimetric Sensing of Ascorbic Acid

Abstract

Metal-organic frameworks (MOFs) have emerged as very fascinating functional materials due to their diversity nature. A nanocomposite consisting of copper nanoparticles dispersed within a carbon matrix (Cu NPs@C) is prepared through a one-pot thermolysis of copper-based metal-organic framework precursors. Cu NPs@C can catalyze the oxidation of 3,3',5,5'-tetramethylbenzidine (TMB) to form a colored product in the presence of H2 O2 . As a peroxidase mimic, Cu NPs@C not only has the advantages of low cost, high stability, and easy preparation, but also follows Michaelis-Menten behaviors and shows strong affinity to H2 O2 . As the Cu NPs' surfaces are free from stabilizing agent, Cu NPs@C exhibited a higher affinity to H2 O2 than horseradish peroxidase. On the basis of the inhibitory effect of ascorbic acid (AA) on oxidation of TMB, this system serves as a colorimetric method for the detection of AA, suggesting that the present work would expand the potential applications of MOF-derived nanocomposites in biomedical fields.

Synthesis of a mixed valence state Ce-MOF as an oxidase mimetic for the colorimetric detection of biothiols

“…11 These enzyme mimics are certainly attractive, but most of them are unstable and prone 35 to be aggregated and settled in aqueous solutions, which might affect their catalytic activity due to the decrease of specific surface area. 12 To address this issue, introduction of surface ligands are necessary, however, tedious surface modification have restricted the catalytic activity of these nanomaterials. 40 Very recently, metal-organic framework (MOF)-a new type of functional materials have attracted considerable attention in the field of enzyme mimics.…”

Bioinspired Synthesis of Cu2+‐Modified Covalent Triazine Framework: A New Highly Efficient and Promising Peroxidase Mimic

“…[8][9][10][11][12][13][14][15][16][17] However, despite this progress, several seriousc hallenges still remain. [19] Most importantly,a lthoughn anoparticles exhibit considerably high surface areas, the effective metal active sites in their internal structures are unavailable for catalysis. [18] Furthermore, in order to improve the stability andd ispersion of nanomaterials, laborious surfacel igand modification is required.…”

Metal‐Organic Frameworks Derived Porous Carbons: Syntheses, Porosity and Gas Sorption Properties

“…Additionally, as mentioned above, higher proportion of microporosity is also needed for larger H 2 adsorption. Influence of metal/metal oxide decoration As mentioned above, in the process of synthesizing M@C, increasing calcination temperature will prompt the aggregation of metal nanoparticles, leading to the decrease of surface areas of M@C. [82][83][84][85][86] But when the metal particles are vaporized, it can always generate extra porosity thereby inspiring researchers to introducing additional metal precursors to expand nanoporosity. Xu's group first invented this method and named it as "double-template approach".…”

“…[82] This phenomenon is also found in other similar works. [83][84][85][86] However, metals/metal oxides do not always negatively affect the porosity. Kim et al reported a material "Ti/NC" (Table 10, No.…”