Metal-organic framework decorated with glycyrrhetinic acid conjugated chitosan as a pH-responsive nanocarrier for targeted drug delivery

Cui, Liu; Wang, Xi; Liu, Zhaoyun; Li, Ziqi; Bai, Ziwei; Lin, Kui; Yang, Jian; Cui, Yuan‐Lu; Tian, Fei

doi:10.1016/j.ijbiomac.2023.124370

Cited by 35 publications

(11 citation statements)

References 46 publications

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“…In this system, glycyrrhetinic acid-modified chitosan served as a carrier for the chemotherapy drug doxorubicin and was loaded into a metal–organic framework. The liver-targeting ligand glycyrrhetinic acid specifically bound to glycyrrhetinic acid receptors overexpressed on liver cancer cell membrane, providing an active targeting effect for the delivery system [ 167 ].…”

Section: Discussionmentioning

confidence: 99%

Collision of herbal medicine and nanotechnology: a bibliometric analysis of herbal nanoparticles from 2004 to 2023

Ai,

Li,

Zheng

et al. 2024

J Nanobiotechnol

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Background Herbal nanoparticles are made from natural herbs/medicinal plants, their extracts, or a combination with other nanoparticle carriers. Compared to traditional herbs, herbal nanoparticles lead to improved bioavailability, enhanced stability, and reduced toxicity. Previous research indicates that herbal medicine nanomaterials are rapidly advancing and making significant progress; however, bibliometric analysis and knowledge mapping for herbal nanoparticles are currently lacking. We performed a bibliometric analysis by retrieving publications related to herbal nanoparticles from the Web of Science Core Collection (WoSCC) database spanning from 2004 to 2023. Data processing was performed using the R package Bibliometrix, VOSviewers, and CiteSpace. Results In total, 1876 articles related to herbal nanoparticles were identified, originating from various countries, with China being the primary contributing country. The number of publications in this field increases annually. Beijing University of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, and Saveetha University in India are prominent research institutions in this domain. The Journal “International Journal of Nanomedicine” has the highest number of publications. The number of authors of these publications reached 8234, with Yan Zhao, Yue Zhang, and Huihua Qu being the most prolific authors and Yan Zhao being the most frequently cited author. “Traditional Chinese medicine,” “drug delivery,” and “green synthesis” are the main research focal points. Themes such as “green synthesis,” “curcumin,” “wound healing,” “drug delivery,” and “carbon dots” may represent emerging research areas. Conclusions Our study findings assist in identifying the latest research frontiers and hot topics, providing valuable references for scholars investigating the role of nanotechnology in herbal medicine. Graphical Abstract

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Section: Discussionmentioning

confidence: 99%

Collision of herbal medicine and nanotechnology: a bibliometric analysis of herbal nanoparticles from 2004 to 2023

Ai,

Li,

Zheng

et al. 2024

J Nanobiotechnol

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“…To control these problems, the conjugation of chitosan and PVP has been recommended to enhance the solubility of chitosan at a high pH level [ 238 , 242 ]. Another method was used to successfully fabricate iron (III) carboxylate metal–organic framework NPs coated with a glycyrrhetinic acid–chitosan conjugate (MIL-101/GA-CS), which behaved as a pH-responsive and target-specific agent to deliver DOX for hepatocellular carcinoma (HCC) therapy ( Figure 7 ) [ 243 ]. These NPs have the advantages of a uniform size, drug encapsulation effectiveness, and pH-dependent targeted drug release.…”

Section: Stimuli-sensitive Deliveries Of Chitosan–dox Npsmentioning

confidence: 99%

Optimized DOX Drug Deliveries via Chitosan-Mediated Nanoparticles and Stimuli Responses in Cancer Chemotherapy: A Review

Imran,

Tang,

Wang

et al. 2023

Molecules

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Chitosan nanoparticles (NPs) serve as useful multidrug delivery carriers in cancer chemotherapy. Chitosan has considerable potential in drug delivery systems (DDSs) for targeting tumor cells. Doxorubicin (DOX) has limited application due to its resistance and lack of specificity. Chitosan NPs have been used for DOX delivery because of their biocompatibility, biodegradability, drug encapsulation efficiency, and target specificity. In this review, various types of chitosan derivatives are discussed in DDSs to enhance the effectiveness of cancer treatments. Modified chitosan–DOX NP drug deliveries with other compounds also increase the penetration and efficiency of DOX against tumor cells. We also highlight the endogenous stimuli (pH, redox, enzyme) and exogenous stimuli (light, magnetic, ultrasound), and their positive effect on DOX drug delivery via chitosan NPs. Our study sheds light on the importance of chitosan NPs for DOX drug delivery in cancer treatment and may inspire the development of more effective approaches for cancer chemotherapy.

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“…So far, GA as an effective liver-specific targeting molecule has been usually used to decorate liposomes, nanomaterials, micelles, and so on to prepare HCC-targeted drug delivery systems. 42−49 For example, Singh and coworkers reported that GA (as an efficient targeting ligand for HCC) conjugation to epirubicin (as an anticancer drug) significantly enhances targeting ability against HCC both in vitro and in vivo; 45 Cai and coworkers reported that metal−organic framework nanoparticles decorated with GA-conjugated chitosan as pH-responsive and targeted selective systems for doxorubicin delivery demonstrated excellent penetration and cancer-killing capabilities in HCC therapy; 46 Yang and coworkers also demonstrated that the NHC−Au(I) complex containing GA (as an active targeting ligand for HCC) displayed better tumor targeting and anticancer activity toward HCC in vitro and in vivo than that of oxaliplatin. 49 Therefore, the above research results suggested that GA, as a highly efficient targeting ligand, has excellent advantages in drug delivery systems for mediating HCC therapy.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Glycyrrhetinic acid (GA), as a pentacyclic triterpenoid derivative extracted from the herb licorice, which has been often used for hepatocyte-targeting ligand due to its specific receptors on the liver cell membrane, exhibited moderate anticancer activity against liver cancer with diverse antitumor mechanisms. − More importantly, many studies suggested that GA could specifically bind to the GA receptor, which is overexpressed on HCC cell lines than that of the adjacent normal liver cells and non-HCC cell lines. − Therefore, GA has been widely used as a ligand for liver targeting. So far, GA as an effective liver-specific targeting molecule has been usually used to decorate liposomes, nanomaterials, micelles, and so on to prepare HCC-targeted drug delivery systems. − For example, Singh and coworkers reported that GA (as an efficient targeting ligand for HCC) conjugation to epirubicin (as an anticancer drug) significantly enhances targeting ability against HCC both in vitro and in vivo; Cai and coworkers reported that metal–organic framework nanoparticles decorated with GA-conjugated chitosan as pH-responsive and targeted selective systems for doxorubicin delivery demonstrated excellent penetration and cancer-killing capabilities in HCC therapy; Yang and coworkers also demonstrated that the NHC–Au(I) complex containing GA (as an active targeting ligand for HCC) displayed better tumor targeting and anticancer activity toward HCC in vitro and in vivo than that of oxaliplatin . Therefore, the above research results suggested that GA, as a highly efficient targeting ligand, has excellent advantages in drug delivery systems for mediating HCC therapy.…”

Section: Introductionmentioning

confidence: 99%

Glycyrrhetinic Acid as a Hepatocyte Targeting Ligand-Functionalized Platinum(IV) Complexes for Hepatocellular Carcinoma Therapy and Overcoming Multidrug Resistance

Huang,

Li,

et al. 2024

J. Med. Chem.

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Promising targeted therapy options to overcome drug resistance and side effects caused by platinum(II) drugs for treatment in hepatocellular carcinoma are urgently needed. Herein, six novel multifunctional platinum(IV) complexes through linking platinum(II) agents and glycyrrhetinic acid (GA) were designed and synthesized. Among them, complex 20 showed superior antitumor activity against tested cancer cells including cisplatin resistance cells than cisplatin and simultaneously displayed good liver-targeting ability. Moreover, complex 20 can significantly cause DNA damage and mitochondrial dysfunction, promote reactive oxygen species generation, activate endoplasmic reticulum stress, and eventually induce apoptosis. Additionally, complex 20 can effectively inhibit cell migration and invasion and trigger autophagy and ferroptosis in HepG-2 cells. More importantly, complex 20 demonstrated stronger tumor inhibition ability than cisplatin or the combo of cisplatin/GA with almost no systemic toxicity in HepG-2 or A549 xenograft models. Collectively, complex 20 could be developed as a potential anti-HCC agent for cancer treatment.

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Metal-organic framework decorated with glycyrrhetinic acid conjugated chitosan as a pH-responsive nanocarrier for targeted drug delivery

Cited by 35 publications

References 46 publications

Collision of herbal medicine and nanotechnology: a bibliometric analysis of herbal nanoparticles from 2004 to 2023

Collision of herbal medicine and nanotechnology: a bibliometric analysis of herbal nanoparticles from 2004 to 2023

Optimized DOX Drug Deliveries via Chitosan-Mediated Nanoparticles and Stimuli Responses in Cancer Chemotherapy: A Review

Glycyrrhetinic Acid as a Hepatocyte Targeting Ligand-Functionalized Platinum(IV) Complexes for Hepatocellular Carcinoma Therapy and Overcoming Multidrug Resistance

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