Metal–organic framework biosensor with high stability and selectivity in a bio-mimic environment

Wu, Xiao-Qin; Ma, Jian‐Gong; Han, Lei; Chen, Di‐Ming; Gu, Wen; Yang, Guangming; Cheng, Peng

doi:10.1039/c5cc02113h

Cited by 74 publications

(25 citation statements)

References 28 publications

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“…MOFs show potential as electrochemical sensing surface modifiers because of their high surface area and pore volume, good absorbability, and high catalytic activity [ 69 , 70 ]. With the rapid development of synthesis methods, stable MOFs with high electrical conductivity have been successfully designed and synthesized [ 71 – 73 ]. However, most MOFs still have poor electrical conductivity and relatively low stability in aqueous solution; this is a result of the reversible nature of the coordination bonds.…”

Section: Mof-based Sensors In Aqueous Solutionmentioning

confidence: 99%

Metal–Organic Framework-Based Sensors for Environmental Contaminant Sensing

2018

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Increasing demand for timely and accurate environmental pollution monitoring and control requires new sensing techniques with outstanding performance, i.e., high sensitivity, high selectivity, and reliability. Metal–organic frameworks (MOFs), also known as porous coordination polymers, are a fascinating class of highly ordered crystalline coordination polymers formed by the coordination of metal ions/clusters and organic bridging linkers/ligands. Owing to their unique structures and properties, i.e., high surface area, tailorable pore size, high density of active sites, and high catalytic activity, various MOF-based sensing platforms have been reported for environmental contaminant detection including anions, heavy metal ions, organic compounds, and gases. In this review, recent progress in MOF-based environmental sensors is introduced with a focus on optical, electrochemical, and field-effect transistor sensors. The sensors have shown unique and promising performance in water and gas contaminant sensing. Moreover, by incorporation with other functional materials, MOF-based composites can greatly improve the sensor performance. The current limitations and future directions of MOF-based sensors are also discussed.

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Section: Mof-based Sensors In Aqueous Solutionmentioning

confidence: 99%

Metal–Organic Framework-Based Sensors for Environmental Contaminant Sensing

2018

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“…The most commonly seen example is the amperometric glucose sensor [1], which has been widely available on the market. During the past five years, numerous zinc-based and copper-based MOFs have been utilized in electrochemical sensing systems operated in phosphate buffer solutions or alkaline electrolytes to detect a range of species including hydrogen peroxide [126][127][128][129], glucose [130], L-cysteine [131], L-tryptophan [132], ascorbic acid [132,133], dopamine [134], and nitrite [135,136]. In 2015, K. C. Ho et al demonstrated the use of a Zr-MOF, MOF-525, to electrochemically detect nitrite in aqueous electrolytes with a natural pH (see Figure 8a) [43].…”

Section: Electroanalysismentioning

confidence: 99%

Metal–Organic Frameworks Toward Electrocatalytic Applications

Wang

Chen

et al. 2019

Applied Sciences

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Metal–organic frameworks (MOFs) are a class of porous materials constructed from metal-rich inorganic nodes and organic linkers. Because of their regular porosity in microporous or mesoporous scale and periodic intra-framework functionality, three-dimensional array of high-density and well-separated active sites can be built in various MOFs; such characteristics render MOFs attractive porous supports for a range of catalytic applications. Furthermore, the electrochemically addressable thin films of such MOF materials are reasonably considered as attractive candidates for electrocatalysis and relevant applications. Although it still constitutes an emerging subfield, the use of MOFs and relevant materials for electrocatalytic applications has attracted much attention in recent years. In this review, we aim to focus on the limitations and commonly seen issues for utilizing MOFs in electrocatalysis and the strategies to overcome these challenges. The research efforts on utilizing MOFs in a range of electrocatalytic applications are also highlighted.

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“…MOFs are notable for their large surface area, highly porous structures, and tunable catalysis capability, all of which are highly demanded for biological sensing. When proper organic ligands are chosen, MOFs can be conductive or semiconductive, leading to development of several electronic devices such as field effect transistors, electric double‐layer capacitors, and sensors . Despite various demonstrations of MOFs in chemical sensing, they have never been demonstrated in implantable biological sensing and integrated with flexible sensors to conduct multichannel determination of nutriments.…”

mentioning

confidence: 99%

Materials and Techniques for Implantable Nutrient Sensing Using Flexible Sensors Integrated with Metal–Organic Frameworks

Ling

Liew

Li³

et al. 2018

Advanced Materials

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The combination of novel materials with flexible electronic technology may yield new concepts of flexible electronic devices that effectively detect various biological chemicals to facilitate understanding of biological processes and conduct health monitoring. This paper demonstrates single- or multichannel implantable flexible sensors that are surface modified with conductive metal-organic frameworks (MOFs) such as copper-MOF and cobalt-MOF with large surface area, high porosity, and tunable catalysis capability. The sensors can monitor important nutriments such as ascorbicacid, glycine, l-tryptophan (l-Trp), and glucose with detection resolutions of 14.97, 0.71, 4.14, and 54.60 × 10 m, respectively. In addition, they offer sensing capability even under extreme deformation and complex surrounding environment with continuous monitoring capability for 20 d due to minimized use of biological active chemicals. Experiments using live cells and animals indicate that the MOF-modified sensors are biologically safe to cells, and can detect l-Trp in blood and interstitial fluid. This work represents the first effort in integrating MOFs with flexible sensors to achieve highly specific and sensitive implantable electrochemical detection and may inspire appearance of more flexible electronic devices with enhanced capability in sensing, energy storage, and catalysis using various properties of MOFs.

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Metal–organic framework biosensor with high stability and selectivity in a bio-mimic environment

Cited by 74 publications

References 28 publications

Metal–Organic Framework-Based Sensors for Environmental Contaminant Sensing

Metal–Organic Framework-Based Sensors for Environmental Contaminant Sensing

Metal–Organic Frameworks Toward Electrocatalytic Applications

Materials and Techniques for Implantable Nutrient Sensing Using Flexible Sensors Integrated with Metal–Organic Frameworks

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