Metal–organic framework based nanozymes: promising materials for biochemical analysis

Niu, Xiangheng; Li, Xin; Lyu, Zhaoyuan; Pan, Jianming; Ding, Shichao; Ruan, Xiaofan; Zhu, Wenlei; Du, Dan

doi:10.1039/d0cc04890a

Cited by 210 publications

(117 citation statements)

References 113 publications

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“…[3][4][5] Some nanomaterials with peroxidase-like activities, such as Fe 3 O 4 , Prussian blue, and some noble-or transition-metal-based nanomaterials, are applied to substitute traditional heme-based catalase enzymes and used in electrochemical sensors. [6][7][8][9] However, their catalytic activities are still much inferior to natural peroxidases and do not exhibit structural resemblance to natural enzymes. [10] Besides, it is also hard to control the molecular architecture and calculate the number of active sites in nanomaterials, which significantly hinders their further practical applications.…”

Section: Introductionmentioning

confidence: 99%

Single‐Atomic Site Catalyst with Heme Enzymes‐Like Active Sites for Electrochemical Sensing of Hydrogen Peroxide

Ding

Lyu

Fang

et al. 2021

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Heme enzymes, with the pentacoordinate heme iron active sites, possess high catalytic activity and selectivity in biosensing applications. However, they are still subject to limited catalytic stability in the complex environment and high cost for broad applications in electrochemical sensing. It is meaningful to develop a novel substitute that has a similar structure to some heme enzymes and mimics their enzyme activities. One emerging strategy is to design the Fe‐N‐C based single‐atomic site catalysts (SASCs). The obtained atomically dispersed Fe‐Nx active sites can mimic the active sites of heme enzymes effectively. In this work, a SASC (Fe‐SASC/NW) is synthesized by doping single iron atoms in polypyrrole (PPy) derived carbon nanowire via a zinc‐atom‐assisted method. The proposed Fe‐SASC/NW shows high heme enzyme‐like catalytic performance for hydrogen peroxide (H2O2) with a specific activity of 42.8 U mg−1. An electrochemical sensor based on Fe‐SASC/NW is developed for the detection of H2O2. This sensor exhibits a wide detection concentration range from 5.0 × 10−10 m to 0.5 m and an excellent limit of detection (LOD) of 46.35 × 10−9 m. Such excellent catalytic activity and electrochemical sensing sensitivity are attributed to the isolated Fe‐Nx active sites and their structural similarity with natural metalloproteases.

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Section: Introductionmentioning

confidence: 99%

Single‐Atomic Site Catalyst with Heme Enzymes‐Like Active Sites for Electrochemical Sensing of Hydrogen Peroxide

Ding

Lyu

Fang

et al. 2021

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“…Metal–organic frameworks (MOFs), which are assembled by the continuous link of coordination bonds between inorganic metal ions (or metal‐oxo clusters) and polydentate organic ligands, are a highly crystalline subset of these fascinating porous materials. With their permanent porosity, exceptionally high internal surface area, wide chemical variety, and tunable topology, MOFs have been examined for their potential in applications such as gas uptake, 1–8 molecular separation, 1,2,9–16 drug delivery, 1,17–20 sensing, 21–25 ion transport, 1,2,26–31 electronic conduction, 1,32–38 among others 39–44 …”

Section: Introductionmentioning

confidence: 99%

Weak Coordination Bond of Chloromethane: A Unique Way to Activate Metal Node Within an Unstable Metal–Organic Framework DUT‐34

Bae

Lee

Jeong

2021

Bulletin Korean Chem Soc

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Activation of metal nodes in metal–organic frameworks (MOFs) has been viewed as an essential step prior to their use for various potential applications. So far, a thermal method has been most commonly employed for the activation despite its negative influence on the structural integrity of MOFs. Meanwhile, DUT‐34 has been considered as an ideal platform for the above applications due to its open‐metal sites (OMSs) at the Cu node. However, the activation of DUT‐34 has not been successful because of its fragile characteristics. In this article, we report the coordination‐chemistry‐controlled activation, namely chemical route activation, using chloromethanes. By monitoring the coordination exchangeability of chloromethanes, we demonstrate that the chloromethanes can weakly coordinate at the OMSs. Further, we demonstrate that this coordination exchange is a safe activation method to retain the framework structure of DUT‐34, based on the observation that the DUT‐34 placed in TCM remained intact over 2 months.

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“…Compared with bioenzymes, nanozymes possess the advantages of low cost, excellent stability, and easy design and regulation. With the catalytic nature to provide amplified signals, nanozymes have found promising applications in biochemical sensing [38][39][40][41], environmental monitoring [42][43][44][45], and food analysis [46][47][48]. For nitrite detection, Liu et al used histidine-capped gold nanoclusters as an oxidase-like nanozyme to catalyze the 3,3 ,5,5 -tetramethylbenzidine (TMB) oxidation and realized both the colorimetric and electrochemical detection of nitrite based on the analyzer suppressing the above reaction [49].…”

Section: Introductionmentioning

confidence: 99%

Ratiometric Colorimetric Detection of Nitrite Realized by Stringing Nanozyme Catalysis and Diazotization Together

et al. 2021

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Due to the great threat posed by excessive nitrite in food and drinking water to human health, it calls for developing reliable, convenient, and low-cost methods for nitrite detection. Herein, we string nanozyme catalysis and diazotization together and develop a ratiometric colorimetric approach for sensing nitrite in food. First, hollow MnFeO (a mixture of Mn and Fe oxides with different oxidation states) derived from a Mn-Fe Prussian blue analogue is explored as an oxidase mimic with high efficiency in catalyzing the colorless 3,3′,5,5′-tetramethylbenzidine (TMB) oxidation to blue TMBox, presenting a notable signal at 652 nm. Then, nitrite is able to trigger the diazotization of the product TMBox, not only decreasing the signal at 652 nm but also producing a new signal at 445 nm. Thus, the analyte-induced reverse changes of the two signals enable us to establish a ratiometric colorimetric assay for nitrite analysis. According to the above strategy, facile determination of nitrite in the range of 3.3–133.3 μM with good specificity was realized, providing a detection limit down to 0.2 μM. Compared with conventional single-signal analysis, our dual-signal ratiometric colorimetric mode was demonstrated to offer higher sensitivity, a lower detection limit, and better anti-interference ability against external detection environments. Practical applications of the approach in examining nitrite in food matrices were also verified.

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Metal–organic framework based nanozymes: promising materials for biochemical analysis

Abstract: In recent years, there has been a rapid growth of enzyme-mimicking catalytic nanomaterials (nanozymes). Compared with biological enzymes, nanozymes exhibit several superiorities, including robust activity, easy production, and low cost,...

Cited by 210 publications

References 113 publications

Single‐Atomic Site Catalyst with Heme Enzymes‐Like Active Sites for Electrochemical Sensing of Hydrogen Peroxide

Single‐Atomic Site Catalyst with Heme Enzymes‐Like Active Sites for Electrochemical Sensing of Hydrogen Peroxide

Weak Coordination Bond of Chloromethane: A Unique Way to Activate Metal Node Within an Unstable Metal–Organic Framework DUT‐34

Ratiometric Colorimetric Detection of Nitrite Realized by Stringing Nanozyme Catalysis and Diazotization Together

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