Metal-Organic Cuboctahedra for Synthetic Ion Channels with Multiple Conductance States

Kawano, Ryuji; Horike, Nao; Hijikata, Yuh; Kondo, Mio; Carné‐Sánchez, Arnau; Larpent, Patrick; Ikemura, Shuya; Osaki, Toshihisa; Kamiya, Kanichi; Kitagawa, Susumu; Takeuchi, Shoji; Furukawa, Shuhei

doi:10.1016/j.chempr.2017.02.002

Cited by 97 publications

(124 citation statements)

References 32 publications

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“…In addition to better stability, the Rh II ‐MOPs recorded better gas sorption properties due to the rigid nature of the Rh 2 paddlewheel units. Recently, Furukawa and co‐workers demonstrated synthetic ion channel properties with multiple conductance states in two rhodium‐based MOPs, in which the alkoxy groups were distinct: [Rh 2 (bdc‐C 12 ) 2 ] 12 (C 12 RhMOP; bdc‐C 12 =5‐dodecyloxy‐1,3‐benzendicarboxylate) and [Rh 2 (bdc‐C 14 ) 2 ] 12 (C 14 RhMOP; bdc‐C 14 =5‐tetradecyloxy‐1,3‐benzenedicarboxylate) . The rhodium paddlewheel motif provides rigidity to the molecular backbone and also imparts high thermal and chemical stability.…”

Section: Design Strategies To Construct Stable Porous Carboxylate Mopsmentioning

confidence: 99%

Stabilizing Metal–Organic Polyhedra (MOP): Issues and Strategies

Mollick

Fajal

Mukherjee

et al. 2019

Chemistry An Asian Journal

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Metal–organic polyhedra (MOPs) are discrete, metal–organic molecular entities composed of edge‐sharing molecular polygons or connected molecular vertices. Unlike the infinite metal–organic coordination networks popularized by metal–organic frameworks (MOFs), spherical MOPs, also known as nanocages, nanospheres, nanocapsules, or nanoballs, are obtained through the self‐organization of metal–carboxylate or metal–pyridine/pyrimidine links to afford cage‐like nanoarchitectures. MOPs offer much promise as porous materials owing to their well‐defined structures and solution processability. However, these advantages become moot if their poor aqueous stability and/or guest‐removal‐induced aggregation handicaps remain unaddressed. The concise premise of this contribution limits our discussion to the design principles in action behind recent developments in stable carboxylate MOPs. To highlight the structure–property relationships between the structural and compositional features of these metal carboxylate polyhedra, related scientific challenges and state‐of‐the‐art research directions for further exploration are presented in brief.

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Section: Design Strategies To Construct Stable Porous Carboxylate Mopsmentioning

confidence: 99%

Stabilizing Metal–Organic Polyhedra (MOP): Issues and Strategies

Mollick

Fajal

Mukherjee

et al. 2019

Chemistry An Asian Journal

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show abstract

“…c2) The multiple conductance states observed from a single molecule. c3) The open‐channel state (duration) can be controlled by changing the outer structure . Reproduced with permission from Ref.…”

Section: Synthetic Ion Channels and Transport Control At The Lipid Bmentioning

confidence: 99%

“…Most approaches utilize voltage gating: an early approach used by Fyles and co‐workers and Kobuke and co‐workers involved an asymmetrical structure with charged parts at one of the termini in the transmembrane molecules. Kawano, Furukawa and co‐workers have also attempted to create gating‐controllable synthetic channels . They focused on metal–organic scaffolds because of the tunability of the structure .…”

Section: Synthetic Ion Channels and Transport Control At The Lipid Bmentioning

confidence: 99%

“…Recently, Kim and co‐workers investigated the capability of metal–organic molecules as synthetic ion channels. Following their study, we synthesized rhodium metal–organic polyhedrals (RhMOPs) that have two different lengths of alkoxy chains (C 12 and C 14 ) at the periphery for controlling the open‐close state, called C 12 RhMOP and C 14 RhMOP . In addition, these RhMOP molecules showed two distinct channel conductance states because the Archimedean geometry of the MOP structure allows porous molecules to possess more than two different polygonal apertures and one internal cavity (Figure c).…”

Section: Synthetic Ion Channels and Transport Control At The Lipid Bmentioning

confidence: 99%

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Synthetic Ion Channels and DNA Logic Gates as Components of Molecular Robots

Kawano

2017

ChemPhysChem

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A molecular robot is a next-generation biochemical machine that imitates the actions of microorganisms. It is made of biomaterials such as DNA, proteins, and lipids. Three prerequisites have been proposed for the construction of such a robot: sensors, intelligence, and actuators. This Minireview focuses on recent research on synthetic ion channels and DNA computing technologies, which are viewed as potential candidate components of molecular robots. Synthetic ion channels, which are embedded in artificial cell membranes (lipid bilayers), sense ambient ions or chemicals and import them. These artificial sensors are useful components for molecular robots with bodies consisting of a lipid bilayer because they enable the interface between the inside and outside of the molecular robot to function as gates. After the signal molecules arrive inside the molecular robot, they can operate DNA logic gates, which perform computations. These functions will be integrated into the intelligence and sensor sections of molecular robots. Soon, these molecular machines will be able to be assembled to operate as a mass microrobot and play an active role in environmental monitoring and in vivo diagnosis or therapy.

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“…Using the DNA origami technology, DNA was assembled into sophisticated nanopores with a gating mechanism, functionally resembling ligand-gated ion channels [78][79][80][81]. A fully designed metal-organic polyhedral pore or amphiphilic molecules were recently incorporated in a lipid bilayer, and those pore properties were characterized [82][83][84][85]. The carbon nanotube (CNT) is another candidate of designed nanopores [86,87].…”

Section: Chemical and Biomolecular Sensingmentioning

confidence: 99%

Membrane protein-based biosensors

Misawa

Osaki

Takeuchi

2018

J. R. Soc. Interface.

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This review highlights recent development of biosensors that use the functions of membrane proteins. Membrane proteins are essential components of biological membranes and have a central role in detection of various environmental stimuli such as olfaction and gustation. A number of studies have attempted for development of biosensors using the sensing property of these membrane proteins. Their specificity to target molecules is particularly attractive as it is significantly superior to that of traditional human-made sensors. In this review, we classified the membrane protein-based biosensors into two platforms: the lipid bilayer-based platform and the cell-based platform. On lipid bilayer platforms, the membrane proteins are embedded in a lipid bilayer that bridges between the protein and a sensor device. On cell-based platforms, the membrane proteins are expressed in a cultured cell, which is then integrated in a sensor device. For both platforms we introduce the fundamental information and the recent progress in the development of the biosensors, and remark on the outlook for practical biosensing applications.

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Metal-Organic Cuboctahedra for Synthetic Ion Channels with Multiple Conductance States

Cited by 97 publications

References 32 publications

Stabilizing Metal–Organic Polyhedra (MOP): Issues and Strategies

Stabilizing Metal–Organic Polyhedra (MOP): Issues and Strategies

Synthetic Ion Channels and DNA Logic Gates as Components of Molecular Robots

Membrane protein-based biosensors

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