Metal nanoparticles in the presence of lipopolysaccharides trigger the onset of metal allergy in mice

Abstract

Many people suffer from metal allergy, and the recently demonstrated presence of naturally occurring metal nanoparticles in our environment could present a new candidate for inducing metal allergy. Here, we show that mice pretreated with silver nanoparticles (nAg) and lipopolysaccharides, but not with the silver ions that are thought to cause allergies, developed allergic inflammation in response to the silver. nAg-induced acquired immune responses depended on CD4(+) T cells and elicited IL-17A-mediated inflammation, similar to that observed in human metal allergy. Nickel nanoparticles also caused sensitization in the mice, whereas gold and silica nanoparticles, which are minimally ionizable, did not. Quantitative analysis of the silver distribution suggested that small nAg (≤10 nm) transferred to the draining lymph node and released ions more readily than large nAg (>10 nm). These results suggest that metal nanoparticles served as ion carriers to enable metal sensitization. Our data demonstrate a potentially new trigger for metal allergy.

Cancer-on-a-chip systems at the frontier of nanomedicine

“…Integrating functional vascular networks into these systems is also crucial to achieve the accurate assessment of the pharmacokinetics and pharmacodynamics of nanomedicine [65,66]. In addition, designs that include immunocompetent microenvironments are of particular interest because of the significant interactions of NPs with the immune system, such as phagocytes in the circulation [67] and immune cells residing in the target tissues [68]. Other factors to consider include the common media that support the viability and functions of all integrated organoids [9,69,70], as well as the proper scaling of the different organoids to ensure a human effect [71].…”

Induced histamine regulates Ni elution from an implanted Ni wire in mice by downregulating neutrophil migration

“…The release of Ni ions from the device led to its dysfunction and to induction of inflammation, allergy and toxicity. Metal nanoparticles are also naturally released from metal alloys used in products such as earrings and wires and cause potent metal allergic sensitization . Therefore, prevention of metal elution from the device will provide an important approach for protection against metal allergy.…”

The Toxicology of Engineered Nanomaterials in Asthma

“…Ce NPs have been shown to have contrasting effects to TiO 2 NPs in that they act as an antioxidant and in vitro promote a T H 2 type environment when dendritic cells are exposed, which go on to induce naïve T cells to produce IL-4 and IL-5 [63]. Ag NP have also been shown to promote allergic inflammation in mice when administered with LPS, which was dependent on CD4 + T cells and resulted in increased IL-17A, an effect not seen with Ag ions [68]. …”