Metal nanoparticles in DBS card materials modification

A large-volume sputum dry storage and transportation device for molecular and culture-based diagnosis of tuberculosis

“…Rather, improved recovery must be the result of more efficient sample recovery, because samples dry as films on glass fibers, whereas in cellulosic fibers, samples get absorbed within the fiber, reducing the efficiency of recovery by centrifugation. 23 The full set of methods and results for RH measurement are provided in the ESI† (Fig. S5–S7).…”

“…A promising alternative to cellulosic membranes is glass fibers, which have recently been shown to have certain advantages for specimen storage. 23,24 Unlike cellulose-based membranes, glass fibers have larger pore sizes, higher volumetric capacity, and less resistance to flow. 25 Lower resistance to flow is an important feature for wicking viscous fluids like sputum.…”

“…In contrast, the components dry out as films on glass fibers. 23 This feature, combined with the fact that glass fiber membranes have a lower capillary pressure owing to their larger pore sizes, makes them more suitable for sample recovery via centrifugation. Finally, glass fiber membranes have higher mechanical strength compared to cellulose-based membranes.…”

“…Finally, glass fiber membranes have higher mechanical strength compared to cellulose-based membranes. 23,24 While most DBS cards are based on cellulosic materials, two commercial DBS cards – Agilent Bond Elut DMS (Santa Clara, CA, USA) and Sartorius glass microfiber filters (Goettingen, Germany) – are made from glass fibers. 27…”