Metal nanoparticles as biospecific contrast agents for cancer imaging

A New Era for Cancer Treatment: Gold‐Nanoparticle‐Mediated Thermal Therapies

“…The final group of gold nanoparticles discussed for hyperthermia applications are gold colloidal nanospheres. Previously, these solid gold spheres were solely investigated for their use as imaging probes 4, 54, 55. However, the small size and relatively simple synthesis of these particles make them appealing for hyperthermia applications.…”

Does conjugation strategy matter? Cetuximab-conjugated gold nanocages for targeting triple-negative breast cancer cells

“…The CTX-conjugated nanocages were characterized by UV-vis spectroscopy and dynamic light scattering (DLS) analysis, determining their hydrodynamic diameter and zeta potential. According to the literature, 54 the conjugation with CTX caused a red-shi of 12-17 nm in the LSPR band for all the samples (Table S1 †), due to a variation in the NP extinction coefficients. These shis were independent of the initial LSPR peak position.…”

Quantitative Real‐Time Monitoring of Antibody‐Induced Internalization of Epidermal Growth Factor Receptor on Single Living Mammalian Cells Using Scanning Electrochemical Microscopy

“…Various measurement and labeling methods have been applied in analyzing the internalization process of EGFR. Radioactive materials,, nanoparticles,, chemiluminescent materials,, and fluorescent materials with immunostaining methods have been widely applied in the detection of cell‐surface EGFR, while many types of toxins, antibodies, inhibitors, genetic mutation samples, and gene knockout samples have been used to identify internalization pathways ,. To clarify the internalization mechanisms via comparison of conditions such as difference in cell type, it is important to develop quantitative measurement methods with low levels of invasiveness (e. g., time‐dependent methods) applicable at the single‐cell level.…”