Metal nanoparticles against multi-drug-resistance bacteria

Mishra, Ajit; Pradhan, Deepak; Halder, Jitu; Biswasroy, Prativa; Kumar, Vineet; Dubey, Debasmita; Kar, Biswakanth; Ghosh, Goutam; Rath, Goutam

doi:10.1016/j.jinorgbio.2022.111938

Cited by 45 publications

(21 citation statements)

References 102 publications

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“…Metallic NPs are an effective solution to overcome bacterial resistance to antibiotics [ 78 , 79 ]. However, some of these NPs are toxic, which severely limits their biomedical applications.…”

Section: Hybrid Nanosystems “Antibiotic—metal Nps” and Their Synerget...mentioning

confidence: 99%

Hybrid Nanosystems of Antibiotics with Metal Nanoparticles—Novel Antibacterial Agents

2023

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The appearance and increasing number of microorganisms resistant to the action of antibiotics is one of the global problems of the 21st century. Already, the duration of therapeutic treatment and mortality from infectious diseases caused by pathogenic microorganisms have increased significantly over the last few decades. Nanoscale inorganic materials (metals and metal oxides) with antimicrobial potential are a promising solution to this problem. Here we discuss possible mechanisms of pathogenic microorganisms’ resistance to antibiotics, proposed mechanisms of action of inorganic nanoparticles on bacterial cells, and the possibilities and benefits of their combined use with antibacterial drugs. The prospects of using metal and metal oxide nanoparticles as carriers in targeted delivery systems for antibacterial compositions are also discussed.

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Section: Hybrid Nanosystems “Antibiotic—metal Nps” and Their Synerget...mentioning

confidence: 99%

Hybrid Nanosystems of Antibiotics with Metal Nanoparticles—Novel Antibacterial Agents

2023

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“…In addition, the formation of this new group (Au-SH) can involve the inhibition of the cell wall synthetase pathway, the disruption of microbial respiration, and the blocking of active transport chains [93]. Finally, ROS (reactive oxygen species)-mediated oxidative stress strongly contributes to the inhibitory mechanism [28]. The presence of NPs inside the cells enhances the production of free radicals, such as O 2 -, H 2 O 2 , and •OH [93].…”

Section: Antimicrobial Activity Of Aunpsmentioning

confidence: 99%

“…Plant extracts have been widely used to produce AuNPs; for example, Aloe vera, Azadirachta indica, Cinnamomum camphora, Medicago sativa, Terminalia catappa, and Coriandrum sativum have been reported as highly efficient agents for the synthesis of AuNPs [26]. It is noteworthy that AuNPs are generally considered less cytotoxic than alternative metal NPs [27,28]. This was another motivation for investigating plant-extract-mediated synthesis of AuNPs.…”

Section: Introductionmentioning

confidence: 99%

Green Synthesis of Gold Nanoparticles by Aqueous Extract of Zingiber officinale: Characterization and Insight into Antimicrobial, Antioxidant, and In Vitro Cytotoxic Activities

Fouda

Eid

Guibal³

et al. 2022

Applied Sciences

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The main challenge for researchers in the biomedical sectors concerns the development of new active compounds through cost-effectiveness, rapid, simple, and ecofriendly methods to overcome antibiotic resistance to pathogenic microbes. Herein, gold nanoparticles (AuNPs) were fabricated by a green approach through the reduction of chloroauric acid (HAuCl4) by harnessing the metabolites present in the aqueous extract of Zingiber officinale rhizome. UV-Vis spectroscopy, FT-IR, XRD, TEM, DLS, and zeta potential were used to characterize phytosynthesized AuNPs. In addition, the antimicrobial effect was investigated against Gram-positive bacteria (Bacillus subtilis and Staphylococcus aureus), Gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli), unicellular fungi (Candida albicans), and multicellular fungi (Aspergillus brasiliensis). Antioxidant and in vitro cytotoxic activities were assessed. TEM and XRD showed the successful formation of spherical and crystalline structures, with sizes in the range of 5–53 nm (average size: 15.11 ± 8.5 nm). The zeta potential value (i.e., –28.8 mV) explains the high stability of synthesized AuNPs. AuNPs exhibit promising activity against prokaryotic and eukaryotic microorganisms with variable inhibition zones and low MIC values in the range of 25–6.25 µg mL−1. Phytosynthesized AuNPs exhibit DPPH scavenging activity with percentages of 87.6 ± 0.5% at a maximum concentration (1000 µg mL−1), which can be compared with ascorbic acid (97.3 ± 0.2%). Moreover, the AuNPs displayed a target-oriented effect for cancer cell lines HepG2 and MCF7 at low IC50 concentrations of 131.9 ± 9.34 and 288.23 ± 31.39 µg mL−1 compared to the normal oral epithelial OEC cell line (487.612 ± 3.53 µg mL−1). Overall, the phytosynthesized AuNPs show wide activities that enable their use in various biomedical and biotechnological applications.

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“…14,15 Therefore, it is essential to optimize their therapeutic efficacy to investigate the drug stability and potential degradation on different non-inert materials, like metal oxide nanocarriers (NCs). [16][17][18] When dealing with nanoparticle-based drug delivery, surfactants are very often mandatory to prevent coalescence and improve colloidal stability. 19,20 However, it was found that this does not preclude the possibility of drug interactions with uncovered regions of the NC surface.…”

Section: Introductionmentioning

confidence: 99%

Stability and potential degradation of the α′,β′-epoxyketone pharmacophore on ZnO nanocarriers: insights from reactive molecular dynamics and density functional theory calculations

2023

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Metal nanoparticles against multi-drug-resistance bacteria

Cited by 45 publications

References 102 publications

Hybrid Nanosystems of Antibiotics with Metal Nanoparticles—Novel Antibacterial Agents

Hybrid Nanosystems of Antibiotics with Metal Nanoparticles—Novel Antibacterial Agents

Green Synthesis of Gold Nanoparticles by Aqueous Extract of Zingiber officinale: Characterization and Insight into Antimicrobial, Antioxidant, and In Vitro Cytotoxic Activities

Stability and potential degradation of the α′,β′-epoxyketone pharmacophore on ZnO nanocarriers: insights from reactive molecular dynamics and density functional theory calculations

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