“…The opposite and complementary polarity between the two sites in the reaction partners, one electronically rich (nucleophilic) and one electronically poor (electrophilic), creates a working mechanism for their engagement in a bonding state. As such, polarity analysis, the formal examination and assignment of electronic character of organic molecule sites, and corresponding electronic character complementarity, has developed into a core synthetic planning practice . Thus far, polarity analysis is executed primarily in the regime of conventional organic chemistry and in the form of static polarity analysis, assignment of electronic character exclusively based on the electronegativity (with resonance effect included) of each site (static polarity: regular polarity and umpolung polarity inversion) and associated complementarity .…”