Metal metabolism in laboratory animals and human tissues as investigated by neutron activation analysis: Current status and perspectives

Sabbioni, E.; Pietra, R.; Marafante, E.

doi:10.1007/bf02515936

Cited by 7 publications

References 25 publications

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Release and detection of dental corrosion products in vivo: Development of an experimental model in rabbits

Reuling

Wisser

Jung

et al. 1990

J. Biomed. Mater. Res.

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An experimental animal model was developed to investigate the release of metal ions from nonprecious dental alloys. Cast specimens of five Ni-Cr-alloys and Co-Cr-alloys were implanted intramuscularly in rabbits for periods of 2, 4, 8, and 12 weeks. The concentrations of nickel, chromium, cobalt, and molybdenum in the implant-loaded muscles were determined by electrothermal atomic absorption spectrometry (AAS) and neutron activation analysis (NAA). Reference muscle samples of each animal were analyzed to determine the individual control values. Significant increases in the tissue concentrations of these metals occurred in the immediate vicinity of the implants. Concentration gradients of the corrosion products were found between the implant contact tissue and the implant periphery (p less than 0.001). Tissue concentrations of nickel and chromium correlated (r less than 0.7). Microprobe analysis before and after implantation of the alloy specimens indicated an even corrosive loss of the alloy surfaces and changes in the surface element distributions. Advantages and limitations of this animal model are discussed, as well as its application in future studies.

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