Metal ion release after total hip replacement

Dobbs, H. S.; Minski, M.J.

doi:10.1016/0142-9612(80)90016-2

Cited by 134 publications

(43 citation statements)

References 33 publications

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“…There is no doubt that metal corrosion from implant surfaces plays a role in prosthesis loosening, as stated by many authors. [1][2][3] An implant corrodes, either electrochemically or mechanically, and metal ions, metal complexes, or particulate metal are released. 2,3 Metal particles generated from metal implants can damage adjacent tissues: high levels of metal often can be detected close to the implant, as well as far from it.…”

Section: Introductionmentioning

confidence: 99%

“…Our results showed a significant increase of Co and Cr serum levels in a patient group with loosened prostheses, confirming data from other studies about corrosion following joint replacement. 1,24 Ion concentration in Hematologic data are reported as number/mm 3 (m ± SEM and median value), and ion concentration is expressed as ng/mL (m ± SEM and median value). *p < 0.05 was considered statistically significant.…”

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confidence: 99%

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Effects of metal ions on white blood cells of patients with failed total joint arthroplasties

Savarino

Granchi

Ciapetti

et al. 1999

J. Biomed. Mater. Res.

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In this study twenty-two patients who had revision surgery for aseptic loosening of joint prostheses were examined. The concentration in serum of soluble products of corrosion from the implant, that is, chromium (Cr), cobalt (Co), and nickel (Ni) ions, and the number of white blood cells (leucocytes, myeloid cells, lymphocyte subpopulations) were measured. Twenty patients with no implants were used as controls. The patients who had revision surgery showed normal Ni concentration whereas by statistical analysis that same patient group was shown to have serum Cr and Co levels significantly higher than those of the control. By flow cytometry, a significant decrease of leucocytes, myeloid cells, lymphocytes, and CD16 populations as found in patients versus controls whereas CD3, CD4, CD8, and CD20 positive cells were decreased, but not significantly. In the arthroplasty patients the Cr concentrations were inversely correlated with some of the immunologic parameters while no significant correlation was found between Co levels and decreased lymphocyte subpopulations. Only in revision surgery patients with high Cr concentrations did we find a significant decrease of lymphocytes, namely of CD4 and CD16 positive cells; revision surgery patients with normal Cr concentrations did not show a significant decrease of lymphocyte subpopulations. These data suggest that the presence of metal ions, especially chromium, released from prosthesis components could be associated with changes of lymphocyte subpopulations in patients with loosening of joint prostheses.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

Effects of metal ions on white blood cells of patients with failed total joint arthroplasties

Savarino

Granchi

Ciapetti

et al. 1999

J. Biomed. Mater. Res.

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“…Furthermore, eroded or partially worn metallic implant surfaces release harmful metallic ions into the human body. [1][2][3] In practice, both problems can be resolved to a large extent by coating the metallic implant with a thin layer of bioactive material such as HA or BG.…”

Section: Introductionmentioning

confidence: 99%

Effects of Different Hydroxyapatite Binders on Morphology, Ca/P Ratio and Hardness of Nd-YAG Laser Clad Coatings

Chien¹,

Han

Hong

et al. 2009

Mater. Trans.

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Hydroxyapatite (HA) is a well known biocompatible coating material used to improve the bonding quality between metallic substrates and the surrounding bone tissue following implantation. In this study, HA is mixed with two different binders, namely water glass (WG) and polyvinyl alcohol (PVA), respectively, and is then clad on Ti-6Al-4V substrates using an Nd:YAG laser beam. The results show that for both binders, the weld surface width, penetration depth and heat affected zone decrease with an increasing travel speed. The PVA binder increases the number and severity of the cracks in the transition layer of the weld bead, whereas the WG binder increases the porosity. In each coating layer, the middle level has the lowest Ca/P ratio, while the lower level has the highest value. Moreover, the Ca/P ratio reduces with an increasing travel speed. The microstructure of the transition layers is mainly composed of CaTiO 3 , Ca 2 P 2 O 7 , TiP 2 , Ti, and HA phases. SiO 2 and Si 2 Ti are additional phases found in the specimen used WG as binder material. The WG binder yields a higher hardness of the coating layer and transition layer than the PVA binder. However, for both binders, the hardness of the transition layer is generally far higher than that of the substrate or the coating layer.

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“…Ions may stay bound to local tissue or bind to protein moieties that are transported via the bloodstream and lymphatics to remote organs. In an early post-mortem study, an increase in the concentrations of Co and Cr in remote tissues (liver and spleen) of a patient with bilateral Co-based alloy total hip components was reported; interestingly, Cr was found in a higher level than Co (Dobbs & Minski, 1980). Michel et al also reported on two post-mortem specimens with CoCr alloy components: in both cases high levels of Co and Cr were detected in adjacent tissues while a wide systemic effect was observed with increased concentrations of Co found in the heart, liver, spleen and lymphatic tissue and of Cr in the aorta, heart, liver, pancreas and spleen (Michel et al, 1991).…”

Section: Dissemination and Biopersistance Of Wear Debris From Implantmentioning

confidence: 99%

The Genotoxic Potential of Novel Materials Used in Modern Hip Replacements for Young Patients

Tsaousi¹

2012

Orthopedic Surgery

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Metal ion release after total hip replacement

Cited by 134 publications

References 33 publications

Effects of metal ions on white blood cells of patients with failed total joint arthroplasties

Effects of metal ions on white blood cells of patients with failed total joint arthroplasties

Effects of Different Hydroxyapatite Binders on Morphology, Ca/P Ratio and Hardness of Nd-YAG Laser Clad Coatings

The Genotoxic Potential of Novel Materials Used in Modern Hip Replacements for Young Patients

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