Metal ion interactions with drugs: Electrochemical study of complexation of various bivalent metal ions with nimesulide and ibuprofen

Kaur, Harminder; Puri, J. K.; Singla, Anita

doi:10.1016/j.molliq.2013.03.005

Cited by 12 publications

(3 citation statements)

References 20 publications

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“…Interestingly, most of the NSAIDs shown to reduce risk of hospitalisation (nimesulide, aspirin and indomethacin) form complexes with zinc, and nimesulide complexes have higher stability than ibuprofen complexes (Baslas et al, 1979 ; Chohan et al, 2002 ; Fini et al, 2001 ; Kaur et al, 2013 ; Yoshikawa et al, 2011 ). Moreover, celecoxib forms water‐insoluble complexes with metal 2+ (Vadivel & Korgaonkar, 2018 ), and several antibiotics including azithromycin and tetracyclines can chelate zinc; the last has also been shown to inhibit matrix metalloproteinases (Arayne et al, 2014 ; Dalhoff, 2021 ).…”

Section: Direct and Indirect Zinc Chelating Properties Of Nsaids And ...mentioning

confidence: 99%

Hypothesis: Efficacy of early treatments with some NSAIDs in COVID‐19: Might it also depend on their direct and/or indirect zinc chelating ability?

Zamai

2022

British J Pharmacology

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Section: Direct and Indirect Zinc Chelating Properties Of Nsaids And ...mentioning

confidence: 99%

Hypothesis: Efficacy of early treatments with some NSAIDs in COVID‐19: Might it also depend on their direct and/or indirect zinc chelating ability?

Zamai

2022

British J Pharmacology

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“…Trinchero et al [ 18 ], as well as Shahabadi and Shiri [ 19 ], reported their spectroscopic behavior, while Kowcun et al [ 20 ] studied the influence of various sources of copper ions on the structure of the complex molecules. Kaur et al [ 21 ] estimated their stability constants, and thermal investigations were conducted by Tita et al [ 22 ]. In vitro anti-inflammatory studies and the DNA interaction and Density Functional Theory modeling of IBU complexes with various metals were conducted by Abbas et al [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Silver and Copper Complexes with Ibuprofen and Caffeine—Preparation and Evaluation of Their Selected Biological Effects

Borówka,

Sierosławska,

Baier

et al. 2024

Molecules

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Several organometallic complexes based on more than twenty different metals have already been approved for medical applications. The aim of the presented research was to obtain complexes of silver and copper with the non-steroidal anti-inflammatory drugs ibuprofen and xanthine alkaloid caffeine and evaluate selected aspects of their bioactivity and biosafety in terms of their future possible applications. The obtained complexes were characterized by Fourier-transform infrared spectroscopy, thermogravimetry, UV-VIS spectroscopy, conductometry, elemental analysis, and bioassays. Cytotoxicity for normal human cells of the CCD-Co18 cell line was evaluated by determining the IC50 value, with metabolic and morphology assessments. It was observed that complexes containing ibuprofen and caffeine exhibited lower toxicity than those with ibuprofen only. Complexes with copper showed lower toxicity towards healthy human fibroblasts compared to silver-based compounds, with an IC50 above 140 μg mL−1. However, in the silver complexes, the presence of caffeine increased the potency of COX-2 inhibition. Antimicrobial effects against different Gram-positive and Gram-negative bacterial strains were evaluated by MIC determination with values less than 20 μg mL−1.

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“…Also various metal ions play significant role in our biological system as almost one-third of the enzymes in our body involve metal ions in execution of different biological functions. Already extensive research work in the field of potentiometric studies of metal ion interactions with various drugs had been reported [13][14][15][16]. These metal ions serve to bind and orient substrates with respect to the functional groups in the active site so that redox reactions can take place by utilizing the property of variable valency of metal ions.…”

Section: Introductionmentioning

confidence: 99%

Stability Constant and Thermodynamic Parameters Determination of A Semi-synthetic Penicillin Derivative with Various Bivalent Metal Ions (Co2+, Ni2+, Cu2+, Zn2+, Cd2+, Sn2+, Hg2+ and Pb2+): A Potentiometric Study

Gupta

2014

IRJPAC

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This present work is a report on the stability constant values of a worthy antibiotic, Ampicillin Trihydrate; D[-]-α-aminobenzyl penicillin; ABP; a semi-synthetic derivative of penicillin with various biologically vital bivalent metal ions (Co 2+ , Ni 2+ , Cu 2+ , Zn 2+ , Cd 2+ , Sn 2+ , Hg 2+ and Pb 2+ ) recorded in water-ethanol medium 50% V/V at three different temperatures (298K, 308K, 318K)maintaining ionic strength at 0.1M KNO 3 . The effect of temperature was also studied and the corresponding thermodynamic functions ∆Gº, ∆Hº and ∆Sº were calculated and discussed. It is significant to study the stability constants of drugs with these metal ions as they may already be present in human body. The proton-ligand and metal-ligand stability constants were determined by Calvin-Bjerrum pH titration techniques as modified by Irving and Rossitti. This analysis was carried out in order to determine the pk 1 H and log k 1 , values at 298 K, 308 K and 318 K. The metal to ligand mole ratio was maintained at 1:5 in order to fulfil the maximum coordination number of metal ion. The titrations were done in a titration cell with three openings, kept immersed in a thermostated bath.

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Metal ion interactions with drugs: Electrochemical study of complexation of various bivalent metal ions with nimesulide and ibuprofen

Cited by 12 publications

References 20 publications

Hypothesis: Efficacy of early treatments with some NSAIDs in COVID‐19: Might it also depend on their direct and/or indirect zinc chelating ability?

Hypothesis: Efficacy of early treatments with some NSAIDs in COVID‐19: Might it also depend on their direct and/or indirect zinc chelating ability?

Silver and Copper Complexes with Ibuprofen and Caffeine—Preparation and Evaluation of Their Selected Biological Effects

Stability Constant and Thermodynamic Parameters Determination of A Semi-synthetic Penicillin Derivative with Various Bivalent Metal Ions (Co2+, Ni2+, Cu2+, Zn2+, Cd2+, Sn2+, Hg2+ and Pb2+): A Potentiometric Study

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