Metal ion imprinted microsphere prepared by surface molecular imprinting technique using water-in-oil-in-water emulsions

Abstract

A novel metal ion imprinted polymer was prepared by the surface molecular imprinting technique. Trimethylolpropane trimethacrylate (TRIM), zinc ions, and 1,12-dodecanediol-O,OЈ-diphenyl phosphonic acid (DDDPA) were used as the matrixforming monomer, imprint molecule, and functional monomer, respectively. We have prepared Zn(II)-imprinted microspheres utilizing water-in-oil-in-water emulsions, which are spherically well defined and uniform. TRIM comprises of three polymerizable groups that serve to align the recognition sites produced on the polymer surface with better template effect. We conducted diagnostic zinc adsorption tests by using the Zn(II)-imprinted and unimprinted polymers in order to make an assessment on the effectiveness of TRIM-based and divinylbenzene-based imprinted polymers. The template effect of the TRIM-based polymer was enhanced by the high rigidity of the polymer matrix compared to that of the imprinted polymer whose matrix is divinylbenzene. In addition, the adsorption equilibrium constant was evaluated on the basis of the Langmuir analysis for the adsorption data. The method to prepare metal-imprinted microspheres on the surface of polymers crosslinked by TRIM is easy, and the adsorbent produced can be readily used without subsequent grinding or sieving.

Metal ion-selective membrane prepared by surface molecular imprinting

“…In previous studies, highly cross-linked polymers (e.g. poly(DVB)) providing rigidity were used as the matrix of the surface imprinted polymer particles [14,17]. However, such a polymer tended to yield a brittle membrane.…”

Ion-imprinted supermacroporous cryogel, for in vitro removal of iron out of human plasma with beta thalassemia

“…In an ion-imprinting process, the selectivity of an imprinted polymeric adsorbent relies on the coordination, the charge and the size of the ion being targeted [12][13][14][15][16][17]. The methodology describing in detail metal ion adsorption have been extensively reported in the literature [18][19][20][21][22][23][24].…”

Preparation and Evaluation of Uniform-size (-)-Ephedrine-imprinted Polymeric Microspheres by Multi-step Swelling and Suspension Polymerization

“…16,17 However, as an HPLC packing material, it is of low column efficiency and higher column pressure. To overcome these problems, spherical MIPs (SMIPs) were prepared using different strategies, such as precipitation polymerization, 18,19 suspension polymerization, 20,21 emulsion polymerization, 22,23 polymerization inside the pores of performed silica beads 4 etc. Among them, a multi-step swelling and suspension polymerization method serves to better control the MIP particles and be accessible to modify particles with a hydrophilic layer.…”